Association of IgG4-related disease and sarcoidosis

Michel, Laure; Clairand, R.; Néel, A.; Masseau, A.; Frampas, É.; Hamidou, M.

doi:10.1136/thx.2011.160341

Cited by 19 publications

(11 citation statements)

References 7 publications

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“…A recent case report documented the occurrence of sarcoidal pathology (noncaseating epithelioid granulomas) in a patient with autoimmune pancreatitis and elevated serum IgG4. 9 Zen and Nakanuma 24 also identified 1 patient with both retroperitoneal fibrosis and sarcoidosis in their cohort of ISD patients.…”

Section: Discussionmentioning

confidence: 91%

Pulmonary Hyalinizing Granuloma With Associated Elevation in Serum and Tissue IgG4 Occurring in a Patient With a History of Sarcoidosis

Chapman

Gown²,

Mazziotta

et al. 2012

American Journal of Surgical Pathology

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Pulmonary hyalinizing granulomas (PHGs) are unusual fibrosclerotic inflammatory lung lesions. The organ-based manifestations of the recently defined IgG4-related sclerosing disease typically show dense fibrosis and heavy lymphoplasmacytic infiltrates. IgG4-related sclerosing disease is also defined by increased serum IgG4 levels and increased tissue levels of IgG4-positive plasma cells. The morphologic features of PHG overlap with those seen in IgG4-related sclerosing disease, and this suggests that PHG may be a form of IgG4-related sclerosing disease. We present a case of a 51-year-old man with a history of sarcoidosis who presented with slowly enlarging pulmonary nodules. Histologic evaluation of one of the nodules yielded a diagnosis of PHG. Further investigation demonstrated both elevated serum IgG4 and elevated tissue IgG4-positive plasma cells in the PHG. In previous reports, lesions that are now considered part of IgG4-related sclerosing disease were documented in patients also diagnosed with PHG, although these reports date from before the description of IgG4 sclerosing disease. This case provides the first definitive evidence that PHG is part of the spectrum of IgG4-related sclerosing disease.

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Section: Discussionmentioning

confidence: 91%

Pulmonary Hyalinizing Granuloma With Associated Elevation in Serum and Tissue IgG4 Occurring in a Patient With a History of Sarcoidosis

Chapman

Gown²,

Mazziotta

et al. 2012

American Journal of Surgical Pathology

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“…The first report on the association of sarcoidosis and IgG4 related disease was by Michel et al [4]. They reported a patient with IgG4 associated autoimmune pancreatitis and sarcoidosis of the salivary gland and celiac lymph nodes [4]. The clinical presentation and radiologic features confirmed sarcoidosis, while pancreas biopsies showed chronic pancreatitis with elevated serum IgG4 values.…”

Section: Discussionmentioning

confidence: 99%

“…An association between IgG4 related disease and sarcoidosis has not widely been published. The first report on the association of sarcoidosis and IgG4 related disease was by Michel et al [4]. They reported a patient with IgG4 associated autoimmune pancreatitis and sarcoidosis of the salivary gland and celiac lymph nodes [4].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, histological resemblance of diseases previously known by different names have since then been subsumed under this new disease category. Sarcoidosis, contrarily, is a chronic granulomatous disease of unknown etiology that has not been systematically associated with IgG4 related disease with the exception of one single case report of contemporaneous involvement of chronic IgG4 associated pancreatitis and pulmonary sarcoidosis [4]. Metachronous development of IgG4 related disease years after a diagnosis of sarcoidosis has not been described previously.…”

Section: Introductionmentioning

confidence: 98%

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Immunoglobulin G4-Related Disease (IgG4-RD) with Associated Sarcoidosis

2013

J Ocul Biol

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Immunoglobulin G-4 related disease represents a collection of tumefactive entities associated with an abundance of infiltrating IgG4 positive plasma cells, which was described first in patients with chronic pancreatitis. Since then, IgG4 related disease has been described in multiple organ systems including the orbit. We describe here a patient with a history of sarcoidosis who was subsequently found to have IgG4 related disease of the orbits, diagnosed by histology and immunohistochemical staining for IgG and IgG4. Microscopic examination of the orbital biopsy demonstrated storiform fibrosis and obliterative phlebitis, as well as a specific IgG4 ratio > 40%. Six years prior, the patient was diagnosed with sarcoidosis clinically and histologically, which proposes the question of a relationship between the two entities. It is unclear from the literature whether IgG 4 related disease represents a diagnosis of its own, and therefore an incidental finding in our case; or whether it is associated with or a consequence of chronic inflammatory diseases in general or in specific cases such as long standing sarcoidosis. Chronic inflammatory processes are known to terminate in proliferative fibrosis at times, rich with IgG4 predominant plasma cells that are histologically identical to findings seen in IgG4 related disease.

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“…Las características mencionadas hacen difícil diferenciar estas dos enfermedades, a veces se trata de manera errónea la IgG4, bajo el supuesto diagnóstico de sarcoidosis (68) e incluso hay reportes en la literatura de pancreatitis por IgG4, con compromiso granulomatoso en ganglios mediastinales y pulmón, donde se plantea la coexistencia de ambas (69). Ante esta difícil situación, se ha propuesto la gammagrafía con galio-67 como herramienta útil en el diagnóstico diferencial, mediante la captación en páncreas, glándulas submandibular (especialmente si es asimétrica) en enfermedad por IgG4, mientras en la sarcoidosis este predomina en glándulas lacrimales, adenopatías supraclaviculares, mediastinales y el tejido muscular (70).…”

Section: Diagnóstico Diferencialunclassified

Sarcoidosis: muchas caras, una enfermedad. Revisión narrativa de la literatura

Chavarriaga-Restrepo

López-Amaya²,

Navas

et al. 2019

Iatreia

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RESUMENLa sarcoidosis es una enfermedad granulomatosa sistémica de etiología desconocida. Esta puede afectar a pacientes de todas las latitudes y edades, siendo más frecuente entre la tercera y cuarta década de la vida con un segundo pico alrededor de los 50 años en las poblaciones escandinava y japonesa. Es más frecuente en mujeres y grave en la población afrodescendiente. Los antígenos que inician esta respuesta granulomatosa son desconocidos, pero se presume que son aerotransportados por la alta frecuencia de compromiso pulmonar en esta enfermedad.Su presentación clínica abarca una amplia gama de manifestaciones, desde formas agudas y limitadas hasta el compromiso crónico con daño orgánico progresivo y muerte. Su diagnóstico se basa en la existencia de los granulomas no caseificantes en los tejidos, con la exclusión de otras enfermedades, entre ellas infección por micobacterias.

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Association of IgG4-related disease and sarcoidosis

Cited by 19 publications

References 7 publications

Pulmonary Hyalinizing Granuloma With Associated Elevation in Serum and Tissue IgG4 Occurring in a Patient With a History of Sarcoidosis

Pulmonary Hyalinizing Granuloma With Associated Elevation in Serum and Tissue IgG4 Occurring in a Patient With a History of Sarcoidosis

Immunoglobulin G4-Related Disease (IgG4-RD) with Associated Sarcoidosis

Sarcoidosis: muchas caras, una enfermedad. Revisión narrativa de la literatura

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