Association of XRCC1 Polymorphisms and Risk of Differentiated Thyroid Carcinoma: A Case–Control Analysis

Abstract

The XRCC1 194Trp variant allele may be associated with increased risk of DTC, while the XRCC1 399Gln variant allele may be associated with decreased risk of DTC. The utility of XRCC1 haplotypes in predicting DTC risk deserves further investigation with direct haplotype measurement.

Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations

“…Tumor histology was assessed by pathologists at each participating institution. The median time from diagnosis to recruitment was 4 years (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Personal and clinical data, such as family history of thyroid cancer and What's new?…”

“…9 Moreover, there is evidence that gene-gene 10,11 and gene-environment interactions 12,13 modulate individual susceptibility. In this scenario, both carefully designed candidate-gene association studies [14][15][16] and genome-wide association studies (GWAS) [17][18][19][20] have been used to identify susceptibility variants for DTC.…”

X-Ray Repair Cross-Complementing Group 1(XRCC1) Genetic Polymorphisms and Thyroid Carcinoma Risk: a Meta-Analysis

“…There are also some case-control studies conducted to explore the association of SNPs of XRCC1 and thyroid cancer risk (Zhu et al, 2004;Chiang et al, 2008;Siraj et al, 2008;Akulevich et al, 2009;Ho et al, 2009;Sigurdson et al, 2009;Fard-Esfahani et al, 2011;García-Quispes et al, 2011;Ryu et al, 2011). However, the results were not consistent.…”

Association between the X-ray repair cross-complementing group 1 Arg194Trp polymorphism and thyroid carcinoma susceptibility: A meta-analysis

“…As a result of database searches, 33 papers were retrieved, of which five full-text articles were ultimately included in our meta-analysis (Chiang et al, 2008;Ho et al, 2009;Fard-Esfahani et al, 2011;Ryu et al, 2011;Santos et al, 2012). A flow chart representing the study selection process is shown in Figure 1.…”