Association of <i>VDR</i> gene polymorphisms and 22 bp deletions in the promoter region of <i>TLR2Δ22 (‐196‐174)</i> with increased risk of pulmonary tuberculosis: A case‐control study in tea garden communities of Assam

Devi, Kangjam Rekha; Mukherjee, Kaustab; Chelleng, P K; Kalita, Simanta; Das, Upasana; Narain, Kanwar

doi:10.1002/jcla.22562

Cited by 8 publications

(3 citation statements)

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“…Based on presenting previously databases, 243 articles were initially included. And a total of 27 [15–41] articles were contained in the present study according to the inclusion and exclusion criteria. The Figure 1 shows in the preferred reporting items for systematic reviews and meta-analyses flow diagram.…”

Section: Resultsmentioning

confidence: 99%

Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to tuberculosis

Wen²,

Wang

2022

Medicine

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Background:To investigate the association between TaqI polymorphism of the vitamin D receptor gene and tuberculosis (TB).Methods:A systematic search was performed in PubMed, Embase, Web of Science, Elsevier Science Direct, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and Chongqing VIP databases for case-control study on TaqI gene polymorphism and TB susceptivity. Quality assessment of studies was performed using the Newcastle–Ottawa Scale for the methodological assessment of case-control studies, and R 4.0.5 software was used for the meta-analysis.Results:Among the 243 selected articles, 27 in the meta-analysis. The meta-analysis showed that the TaqI gene polymorphism allene gene model (t vs T, odds ratio [OR]: 1.12, 95% confidence interval [CI]: 0.99–1.27); dominant model (tt + tT vs TT, OR: 1.12, 95% CI: 0.98–1.29); recessive model (tt vs tT + TT, OR: 1.25, 95% CI: 1.03–1.51); codominant A (tt vs TT, OR: 1.37, 95% CI: 1.00–1.87); codominant B (tT vs TT, OR: 1.09, 95% CI: 0.99–1.19). And subgroup dominant model (tt + tT vs TT, OR: 1.27, 95% CI: 1.03–1.55) in Indianas, recessive model (tt vs tT + TT, OR: 1.49, 95% CI: 1.05–2.11) in Iranians, co-dominant B (tT vs TT, OR: 1.28, 95% CI: 1.03–1.59; OR: 1.42, 95% CI: 1.05–1.93) in Indianas and Iranians.Conclusion:This meta-analysis suggests a significant association between TB and the risk of TaqI in Iranians and Indians, but the vitamin D receptor polymorphism TaqI was not associated with Chinese. Thus, validation studies will be required to confirm these findings.

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Section: Resultsmentioning

confidence: 99%

Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to tuberculosis

Wen²,

Wang

2022

Medicine

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“…[9,10,11] Hence, decreased levels of Vit D and/or impaired receptor structure and function might lead to compromised immunity towards the pathogen. [8,10] Genetic polymorphisms in the VDR gene might affect the structure of the VDR protein or cause defects in its regulation or function, which in turn can alter the biological functions of Vitamin D. There are more than 25 VDR polymorphisms in the 5' regulatory region, 3'UTR and other coding regions [18], four being the most relevant among them namely ApaI(intron VIII), BsmI (intron VIII), TaqI (Exon IX) and FokI (Exon II). [17,18], which will be further analysed in the following sections.…”

Section: Introductionmentioning

confidence: 99%

Reassessing the association of VDR and its polymorphisms with tuberculosis in global populations

Das,

Chaubey

2023

Preprint

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BackgroundVitamin D is a hormone that regulates the calcium homeostasis of the body. Besides this classical function, it is also regarded as an important immunomodulator. Most active Vitamin D actions are mediated through the Vitamin D receptor (VDR), a transcription factor and also a member of the nuclear receptor superfamily. In this study, we explored the phylogeographic attributes of the four most well-known polymorphisms of the VDR gene namely rs7975232 (ApaI), rs731235 (TaqI), rs1544410 (BsmI), rs2228570 (FokI) and also evaluated their association with the incidence of tuberculosis in global populations. This study integrated several in-silico approaches on population databases to evaluate the pattern of distribution, linkage and selection patterns of these SNPs.ResultsThe ancestral alleles of rs7975232, rs731235, and rs1544410 are still present in over 50% frequency in modern human populations. These SNPs also have a very strong linkage disequilibrium among themselves in all population groups but no haplotype blocks are seen in South Asian populations constituting these polymorphisms. The selection results reveal a negative Tajima’s D value in West and East Eurasian populations suggesting positive selection in these regions… In correlation studies, we found no association between the incidence of tuberculosis and the allele or genotype frequency of these four SNPs.ConclusionThe four SNPs of VDR behave differently in South Asian populations as compared to West and East Eurasian populations but no significant association was found with the incidence of tuberculosis in global populations.

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“…But the results of these studies were not consistent. 11–52 Thus, we performed the present meta-analysis to obtain a more conclusive result.…”

Section: Introductionmentioning

confidence: 99%

Associations between vitamin D receptor genetic variants and tuberculosis: a meta-analysis

Shen

2019

Innate Immun

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We performed a meta-analysis to evaluate potential associations between vitamin D receptor ( VDR) genetic variants and tuberculosis (TB). Systematic literature research was conducted in PubMed, Web of Science, and Embase. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) to estimate strength of associations in all possible genetic models, and P values ≤ 0.05 were considered to be statistically significant. In total, 42 studies were enrolled for analyses. Pooled overall analyses suggested that VDR rs1544410 (dominant model: P = 0.02; allele model: P = 0.03) and rs731236 (dominant model: P = 0.04; recessive model: P = 0.02; allele model: P = 0.01) variants were significantly associated with TB. Further subgroup analyses by ethnicity revealed that rs1544410 (dominant and allele models) and rs731236 (dominant, recessive, and allele models) variants were both significantly associated with TB in South Asians. When we stratified data by type of disease, positive results were detected for rs7975232 variant in EPTB (dominant, recessive, over-dominant, and allele models) subgroup, and for rs2228570 variant in PTB (dominant, recessive, and allele models) and EPTB (dominant, recessive, over-dominant, and allele models) subgroups. Our meta-analysis supported that rs7975232, rs1544410, rs2228570, and rs731236 variants might serve as genetic biomarkers of certain types of TB.

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Association of VDR gene polymorphisms and 22 bp deletions in the promoter region of TLR2Δ22 (‐196‐174) with increased risk of pulmonary tuberculosis: A case‐control study in tea garden communities of Assam

Abstract: This study has revealed that BsmI and FokI polymorphisms of VDR gene significantly associated with an increased risk of PTB.

Cited by 8 publications

References 50 publications

Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to tuberculosis

Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to tuberculosis

Reassessing the association of VDR and its polymorphisms with tuberculosis in global populations

Associations between vitamin D receptor genetic variants and tuberculosis: a meta-analysis

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