Association of <i>TNF, IL12,</i> and <i>IL23</i> gene polymorphisms and psoriatic arthritis: meta-analysis

Loures, Marco Antonio Rocha; Alves, Hugo Vicentin; Moraes, Amarilis Giaretta de; Santos, Thaís da Silva; Lara, Fernanda Formaggi; Neves, Janisleya Silva Ferreira; Macedo, Luciana Conci; Teixeira, Jorge Juarez Vieira; Sell, Ana Maria; Visentainer, Jeane Eliete Laguila

doi:10.1080/1744666x.2019.1564039

Cited by 13 publications

(7 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The phosphorylated STAT dimers enter the nucleus and act on downstream target genes. IL-23R has been identified to associate with multiple diseases, including alopecia areata (rs10889677) and nephropathy (rs10805303) (Figure 3) (Safrany et al, 2011;Yu et al, 2012;Huang et al, 2016;Qin et al, 2016;Poomarimuthu et al, 2018;Sode et al, 2018;Zhong et al, 2018;Kramer et al, 2019;Loures et al, 2019;Ruyssen-Witrand et al, 2019;Tabatabaei-Panah et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

Wang

Fan

et al. 2020

Front. Neurosci.

View full text Add to dashboard Cite

Background: Cerebral palsy (CP) is a syndrome of non-progressive motor dysfunction caused by early brain development injury. Recent evidence has shown that immunological abnormalities are associated with an increased risk of CP.Methods: We recruited 782 children with CP as the case group and 770 healthy children as the control group. The association between IL-23R single nucleotide polymorphisms (SNPs; namely, rs10889657, rs6682925, rs1884444, rs17375018, rs1004819, rs11805303, and rs10889677) and CP was studied by using a case–control method and SHEsis online software. Subgroup analysis based on complications and clinical subtypes was also carried out.Results: There were differences in the allele and genotype frequencies between CP cases and controls at the rs11805303 and rs10889677 SNPs (Pallele = 0.014 and 0.048, respectively; Pgenotype = 0.023 and 0.008, respectively), and the difference in genotype frequency of rs10889677 remained significant after Bonferroni correction (Pgenotype = 0.048). Subgroup analysis revealed a more significant association of rs10889677 with CP accompanied by global developmental delay (Pgenotype = 0.024 after correction) and neonatal encephalopathy (Pgenotype = 0.024 after correction).Conclusion: The present results showed a significant association between IL-23R and CP, suggesting that IL-23R may play a potential role in CP pathogenesis.

show abstract

Section: Discussionmentioning

confidence: 99%

The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

Wang

Fan

et al. 2020

Front. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Выявлены также варианты гена IL23R, уменьшающие вероятность развития псориатического поражения суставов. Протективный эффект в отношении возникновения псориатического артрита был обнаружен у миссенс-варианта IL23R rs11209026*(G>A) [35]. Известными в настоящее время механизмами, которые обуславливают проявление протективного эффекта Таблица.…”

Section: разделunclassified

“…Генетические маркеры, определяющие предрасположенность к развитию псориатического артрита у больных псориазом [37]. Метаанализ позволил обнаружить повышение риска развития псориатического артрита у носителей генотипа rs6887695 IL12B*C>G (отношение шансов -1,331) [35]. В китайской популяции выявлена ассоциация псориатического артрита с минорным аллелем rs2082412*А в гене IL12B (отношение шансов -0,7) [38].…”

Section: разделunclassified

“…Проведенный метаанализ показал наличие сниженного риска развития псориатического артрита у индивидов с аллельным вариантом полиморфизма гена IL12B rs3212227*С. Показано, что генотипы CC и CA уменьшают вероятность развития псориатического поражения суставов (отношение шансов OR = 0,526 -для генотипов CC vs AA, OR = 0,745 -для генотипов CA vs AA, OR = 0,722 -при сравнении CC + CA vs AA) [35].…”

Section: разделunclassified

See 1 more Smart Citation

Genetic markers for psoriatic arthritis in patients with psoriasis. Part I: non-HLA genes

Kubanov

Карамова

Чикин

et al. 2021

Vestnik dermatologii i venerologii

View full text Add to dashboard Cite

Psoriatic arthritis often develops in patients with psoriasis and can lead to joint deformity, stiffness, dysfunction, and disability. Psoriatic arthritis is a polygenic disease. and the issue of personalizing the prognosis of its development can only be resolved taking into account the variability of plenty genomic loci associated with the development of the disease. The personification of the prognosis of the disease can be solved taking into account the variability of the set of genomic loci with which its development is associated. The review examines genomic polymorphisms associated with the development of psoriatic arthritis not psoriasis, except of HLA polymorphisms. Genome regions containing polymorphisms, allelic variants of which are associated both with the development of psoriatic arthritis and reducing the likelihood of its occurrence, are described. It has been reported that the predisposition to the development of psoriatic arthritis in patients with psoriasis is determined by genes encoding proteins involved in inflammation and bone metabolism.

show abstract

“…IL‐12B is located on chromosome 5q31. IL‐12B gene polymorphisms are heavily involved in many autoimmune disorders, such as psoriatic arthritis, 15 multiple sclerosis, 16 and rheumatoid arthritis 17 . An association between IL‐12B gene polymorphisms (rs6887695 and rs2288831) and UC risk has been reported in various populations 18‐22 .…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐12B gene rs6887695 and rs2288831 polymorphisms are associated with an increased risk of ulcerative colitis development in Chinese Han population: A case‐control study

Zhao

Qian

2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), a prevalent chronic inflammatory disorder, occurs due to an abnormal immune reaction to intraluminal antigens in genetically predisposed individuals. 1 Distinct subtypes of IBD include Crohn's disease (CD) and ulcerative colitis (UC). The incidence of UC has been increasing worldwide for decades, particularly in developed countries. 2 UC has a prevalence rate of 0.02%-0.5% in the general population. 1 UC can be induced by many factors, including an abnormal immune reaction epithelial barrier disruption, genetic predisposition, and environmental causes. 3 Genome-wide association assays have revealed hundreds of genetic variants in UC, 4-6 which are regarded as susceptible sites for UC.

show abstract

Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis

Cited by 13 publications

References 94 publications

The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

The Association Study of IL-23R Polymorphisms With Cerebral Palsy in Chinese Population

Genetic markers for psoriatic arthritis in patients with psoriasis. Part I: non-HLA genes

Interleukin‐12B gene rs6887695 and rs2288831 polymorphisms are associated with an increased risk of ulcerative colitis development in Chinese Han population: A case‐control study

Contact Info

Product

Resources

About