Association of<i>TLR2</i>Gene Polymorphisms With Ocular Behçet's Disease in a Chinese Han Population

Fang, Jing; Hu, Ranran; Hou, Shengping; Ye, Zi; Qin, Xiang; Qi, Jian; Zhou, Yan; Kijlstra, Aize; Yang, Peizeng

doi:10.1167/iovs.13-12878

Cited by 43 publications

(33 citation statements)

References 40 publications

(46 reference statements)

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“…Moreover, associations between the TLR2 genetic diversity and Alzheimer's disease [61] or cognitive function in schizophrenia [62] are highly suggestive of genetically-driven inter-individual ability to modulate neuroinflammatory processes. Of importance is that the TLR2 rs3804099 polymorphism was showed on the one hand to be associated with several inflammatory and infectious diseases including pulmonary tuberculosis, neonatal infection, filariasis, ocular Behcet's disease and cancer [63][64][65][66][67] and to exert a functional impact on the inflammatory response on the other [65,68,69].…”

Section: Discussionmentioning

confidence: 99%

Combined Effect of TLR2 Gene Polymorphism and Early Life Stress On the Age at Onset of Bipolar Disorders

Oliveira

Étain

Lajnef

et al. 2015

European Psychiatry

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Gene-environment interactions may play an important role in modulating the impact of earlylife stressful events on the clinical course of bipolar disorder (BD), particularly associated to early age at onset. Immune dysfunction is thought to be an important mechanism linking childhood trauma with early-onset BD, thus the genetic diversity of immune-related loci may account for an important part of the interindividual susceptibility to this severe subform. Here we investigated the potential interaction between genetic variants of Toll-like receptors 2 (TLR2) and 4 (TLR4), major innate immune response molecules to pathogens, and the childhood trauma questionnaire (CTQ) in age at onset of BD. We recruited 531 BD patients (type I and II or not otherwise specified), genotyped for the TLR2 rs4696480 and rs3804099 and TLR4 rs1927914 and rs11536891 single-nucleotide polymorphisms and recorded for history of childhood trauma using the CTQ. TLR2 and TLR4 risk genotype carrier state and history of childhood emotional, physical and sexual abuses were evaluated in relation to age at onset as defined by the age at first manic or depressive episode. We observed a combined effect of TLR2 rs3804099 TT genotype and reported sexual abuse on determining an earlier age at onset of BD by means of a Kaplan-Meier survival curve (p = 0.002; corrected p = 0.02). Regression analysis, however, was non-significant for the TLR2-CTQ sexual abuse interaction term. The negative effects of childhood sexual abuse on age at onset of BD may be amplified in TLR2 rs3804099 risk genotype carriers through immune-mediated pathways. Clinical characteristics of illness severity, immune phenotypes and history of early life infectious insults should be included in future studies involving large patient cohorts.

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Section: Discussionmentioning

confidence: 99%

Combined Effect of TLR2 Gene Polymorphism and Early Life Stress On the Age at Onset of Bipolar Disorders

Oliveira

Étain

Lajnef

et al. 2015

European Psychiatry

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“…68 Eight SNPs in TLR2, TLR4, TLR8, and TLR9 were examined to test the association with BD, VKH syndrome, and AAU. 53 The results only showed association of genetic variants in TLR2 with BD. No association was observed with VKH syndrome and AAU, despite the fact that large patient samples were included in these studies.…”

Section: Molecular Genetic Studies On the Genes Involved In The Innatmentioning

confidence: 89%

Molecular Genetic Advances in Uveitis

Hou¹,

Kijlstra²,

Yang³

2015

Progress in Molecular Biology and Translational Science

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“…In the two-stage control-association study performed by Fang and colleagues [186], an association between ocular BD and TLR2 SNPs (rs2289318 and rs3804099) was observed in a Han Chinese population, although these two SNPs did not exert any effect on the release of TNF-, IL-6, IL-10, and IL-1 No association was reported between BD and TLR2 SNP (rs13150331), TLR4 SNP (rs7037117), TLR8 SNP (rs3764880) and TLR9…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Gene/environment interactions in the pathogenesis of autoimmunity: New insights on the role of Toll-like receptors

Gianchecchi

Fierabracci

2015

Autoimmunity Reviews

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Association ofTLR2Gene Polymorphisms With Ocular Behçet's Disease in a Chinese Han Population

Abstract: This study provides evidence that the TLR2 gene is involved in the susceptibility to ocular BD.

Cited by 43 publications

References 40 publications

Combined Effect of TLR2 Gene Polymorphism and Early Life Stress On the Age at Onset of Bipolar Disorders

Combined Effect of TLR2 Gene Polymorphism and Early Life Stress On the Age at Onset of Bipolar Disorders

Molecular Genetic Advances in Uveitis

Gene/environment interactions in the pathogenesis of autoimmunity: New insights on the role of Toll-like receptors

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