Association of <i><scp>S</scp>treptococcus bovis</i> endocarditis and advanced colorectal neoplasia: A case–control study

Sharara, Ala I.; Hamdan, Tarek Abou; Malli, Ahmad; El-Halabi, Mustapha; Hashash, Jana G.; Ghaith, Ola; Kanj, Souha S.

doi:10.1111/1751-2980.12059

Cited by 25 publications

(13 citation statements)

References 23 publications

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“…46 A more recent study found that 52% of SB bacteremia patients had advanced adenoma/cancer, which was approximately 2.5 fold more frequent than colonoscopy controls. 47 Similar prevalence (60%) of advanced adenoma/cancer was reported in SB endocarditis patients by Sharara et al 48 …”

Section: Epidemiological Studies Of Microbiome and Colorectal Cancersupporting

confidence: 77%

Gut microbiota, inflammation and colorectal cancer

2016

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Although genes contribute to colorectal cancer, the gut microbiota are an important player. Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression. A variety of bacterial species and tumor-promoting virulence mechanisms have been investigated. Significant advances have been made in understanding the composition and functional capabilities of the gut microbiota and its roles in cancer. In the current review, we discuss the novel roles of microbiota in the progression of colon cancer. Although microbiota technically include organisms other than bacteria e.g., viruses and fungi, this review will primarily focus on bacteria. We summarize epidemiological studies of human microbiome and colon cancer. We discuss the progress in the scientific understanding of the interplay between the gut microbiota, barrier function, and host responses in experimental models. Further, we discuss the potential application in prevention, diagnosis, and therapy of colon cancer by targeting microbiota. We discuss the challenges lie ahead and the future direction in studying gut microbiome in colon cancer to close the gap between the basic sciences and clinical application.

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Section: Epidemiological Studies Of Microbiome and Colorectal Cancersupporting

confidence: 77%

Gut microbiota, inflammation and colorectal cancer

2016

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“…Although the pathophysiologic relationship between endocarditis and neoplasm remains unclear, the simultaneous finding of both entities is not rare (16). Thomsen et al (17) recently proposed that endocarditis is a substantial clinical marker for the presence of occult cancer, with a standardized incidence rate of 1.61 (confidence interval, 1.5-1.71).…”

Section: Discussionmentioning

confidence: 99%

Role of ¹⁸F-FDG PET in Patients with Infectious Endocarditis

et al. 2014

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It was our purpose to evaluate the clinical impact of systematic PET/CT for the diagnosis of infectious embolisms in patients with infectious endocarditis (IE) in comparison with a historic cohort of IE patients managed without this technique. Detection of extracardiac lesions is an essential component of the management and outcome of IE. Studies using PET/CT for the evaluation of patients with IE are scarce, lack a control group, evaluate a small number of patients, or consist of case reports. Methods: We performed a prospective cohort study (47 patients with definite IE undergoing PET/ CT) with matched controls (94 patients with definite IE not undergoing PET/CT) from January 2012 to July 2013 in a tertiary hospital. The results were compared with those of conventional diagnostic techniques and clinical follow-up. Results: PET/CT revealed at least 1 lesion in 35 patients (74.5%): 18 showed an embolic complication, 8 showed pathologic uptake on the valves or cardiac devices, 1 showed both, 5 had incidental noninfectious findings, and the findings for 3 were considered false-positive. The validity values for the efficacy of PET/CT in the diagnosis of septic lesions were as follows: sensitivity, 100%; specificity, 80%; positive predictive value, 90%; and negative predictive value, 100%. PET/CT was the only initially positive imaging technique in 15 true-positive cases (55.5%). The systematic use of PET/CT was associated with a 2-fold reduction in the number of relapses (9.6% vs. 4.2%, P 5 0.25) and enabled significantly more infectious complications to be diagnosed (18% vs. 57.4%, P 5 0.0001). Conclusion: PET/CT enables the extent of IE to be assessed using a single test. It is fast (,2 h) and comfortable for the patient, gathers whole-body data, and detects significantly more infectious complications.

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“…The association between CRC and endocarditis was first proposed decades ago [4], and is supported by several case series [5] and small case-control studies [6–8]. A meta-analysis of these case-control studies found a strong association (odds ratio 14.5, 95% confidence interval 5.7–37.6), but it was based on only 16 CRC patients with endocarditis [9] and could not provide information about the incidence of endocarditis around CRC diagnosis.…”

Section: Introductionmentioning

confidence: 90%

Infective endocarditis and cancer in the elderly

et al. 2015

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Background Little is known about the magnitude of the association between infective endocarditis and cancer, and about the natural history of cancer patients with concomitant diagnosis of infective endocarditis. Methods We used the SEER-Medicare linked database to identify individuals aged 65 years or more diagnosed with colorectal, lung, breast, or prostate cancer, and without any cancer diagnosis (5% random Medicare sample from SEER areas) between 1992–2009. We identified infective endocarditis from the ICD-9 diagnosis of each admission recorded in the Medpar file and its incidence rate 90 days around cancer diagnosis. We also estimated the overall survival and CRC-specific survival after a concomitant diagnosis of infective endocarditis. Results The peri-diagnostic incidence of infective endocarditis was 19.8 cases per 100,000 person-months for CRC, 5.7 cases per 100,000 person-months for lung cancer, 1.9 cases per 100,000 person-months for breast cancer, 4.1 cases per 100,000 person-months for prostate cancer and 2.4 cases per 100,000 person-months for individuals without cancer. Two-year overall survival was 46.4% (95% CI 39.5, 54.5%) for stage I–III CRC patients with concomitant endocarditis and 73.1% (95% CI 72.9, 73.3%) for those without it. Conclusion In this elderly population, the incidence of infective endocarditis around CRC diagnosis was substantially higher than around the diagnosis of lung, breast and prostate cancers. A concomitant diagnosis of infective endocarditis in patients with CRC diagnosis is associated with shorter survival.

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Association of Streptococcus bovis endocarditis and advanced colorectal neoplasia: A case–control study

Cited by 25 publications

References 23 publications

Gut microbiota, inflammation and colorectal cancer

Gut microbiota, inflammation and colorectal cancer

Role of ¹⁸F-FDG PET in Patients with Infectious Endocarditis

Infective endocarditis and cancer in the elderly

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Association of Streptococcus bovis endocarditis and advanced colorectal neoplasia: A case–control study

Cited by 25 publications

References 23 publications

Gut microbiota, inflammation and colorectal cancer

Gut microbiota, inflammation and colorectal cancer

Role of 18F-FDG PET in Patients with Infectious Endocarditis

Infective endocarditis and cancer in the elderly

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Role of ¹⁸F-FDG PET in Patients with Infectious Endocarditis