Association of <i><scp>HLA</scp>‐<scp>DRB1</scp></i> alleles and anti‐neutrophil cytoplasmic antibodies in <scp>H</scp>an and Uyghur patients with ulcerative colitis in <scp>C</scp>hina

Gao, Feng; Ayinuer, Aheman; Lu, Junlin; Abuduhadeer, Mireayi; Li, Yue Xian; Kuerbanjiang, Aihemaijiang

doi:10.1111/1751-2980.12143

Cited by 7 publications

(5 citation statements)

References 26 publications

(38 reference statements)

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“…In Han patients with UC, there was no significant difference in HLA-DRB1 frequency between UC patients and healthy controls. [10,11] In addition, we have also confirmed that the fucosyltransferase 2 (FUT2) variant rs281377 was significantly associated with UC in the Han population as compared with the controls (P = .011) while rs281377 was not associated with UC in the Uyghur population (P = .06). [12] Xinjiang is a multi-ethnic gathering place, where each ethnic group has different genetic characteristics, living, and eating habits.…”

Section: Introductionsupporting

confidence: 55%

“…However, the HLA-DRB1 ∗ 08 gene frequency was lower in the UC patients than in the control group ( P = .012, Odds Ratio 0.12, 95% Confidenceinterval (CI) 0.02–0.91). In Han patients with UC, there was no significant difference in HLA-DRB1 frequency between UC patients and healthy controls [10,11] . In addition, we have also confirmed that the fucosyltransferase 2 (FUT2) variant rs281377 was significantly associated with UC in the Han population as compared with the controls ( P = .011) while rs281377 was not associated with UC in the Uyghur population ( P = .06) [12] …”

Section: Introductionsupporting

confidence: 53%

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Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China

Liu

Huang

et al. 2021

Medicine

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To determine the differences in intestinal flora between Uygur and Han patients with ulcerative colitis (UC).Microbial diversity and structural composition of fecal bacteria from patients with UC and their matched healthy spouses or firstdegree relatives were analyzed using high-throughput sequencing technology.The fecal microbial diversity and abundance index of Uygur patients with UC (UUC) were significantly lower compared with the Uygur normal control group, while there was no significant difference between the Han UC patients (HUC) and the Han normal control group (HN). Compared with their respective control groups, Uygur UC patients and Han UC patients had a different main composition of human intestinal flora (P < .05). The abundance of Burkholderia, Caballeronia, Paraburkholderia in the UUC group were higher compared with the HUC group, while Faecalibacterium, Bifidobacterium, and Blautia in the HUC group were higher than those in the UUC group (P < .05). Veillonella in the UUC group was higher than that in the Uygur normal control group group, while Subdoligranulum and Ruminococcaceae_UCG-002 were significantly lower (P < .05). Prevotella_9 in the HUC group was significantly higher than that in HN group, while Blautia, Anaerostipes, and [Eubacterium]_hallii_group were significantly lower. Moreover, the top 6 species in order of importance were Christensenellaceae_R_7_group, Ruminococcae_ucg_005, Ruminococcae_ucg_010, Ruminococcae_ucg_013, Haemophilus, and Ezakiella.The difference in intestinal microflora structure may be one of the reasons for the clinical heterogeneity between Uygur and Han patients with UC. Christensenellaceae_R_7_group, Ruminococcae_ucg_005, Ruminococcae_ucg_010, Ruminococcae_ucg_013, Haemophilus, and Ezakiella could be used as potential biomarkers for predicting UC.

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Section: Introductionsupporting

confidence: 55%

Section: Introductionsupporting

confidence: 53%

Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China

Liu

Huang

et al. 2021

Medicine

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“…A study aimed to explore the association between HLA-DRB1 alleles and anti-neutrophil cytoplasmic antibodies among Uyghur and Han patients with ulcerative colitis in China finds Genetic polymorphisms of the HLA-DRB1*08 and *13 may contribute to the clinical heterogeneity of ulcerative colitis between Uyghur and Han ulcerative colitis patients in China. In Uyghur ulcerative colitis patients, HLA-DRB1*13 may be correlated with anti-neutrophil cytoplasmic antibodies positivity [26]. The gene frequencies of ADH2(2) and ALDH2(2) were lower in Tibetan and Mongolian populations than in Vietnamese, Han Chinese, and three Chinese minority populations [27].…”

Section: Explanationsmentioning

confidence: 96%

Ethnic Difference of Disease Prevalence in Rural China: Examples and Explanations

Guan¹

2015

Health

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Ethnic difference of disease prevalence has attracted great attentions in recent years in China, but few researches have summarized analysis available on ethnic difference of disease prevalence in rural China. The PubMed Central, Wiley Inter science, Science direct, Biomed central, CNKI and Springer-link were searched to identify studies published between January 1984 and October 2014 on ethnic inequality of health status in rural China. Distinct ethnic differences of disease prevalence exist in rural China. Results across disciplines put different explanations on the ethnic differences from ethnicity, infant feeding, and inequality in maternal health services utilization angles. The ethnic inequality of health status in rural China can be reduced by policy makers to allocate more resources towards health service in ethnic rural China.

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“… 10 Furthermore, the incidence of UC in Xinjiang region was relatively high in China. 11 Besides, some differential manifestations of UC in Uyghur and Han patients have been documented previously, such as more moderate/severe forms and a higher complication rate, 12 higher endoscopic detection rate of UC, 11 and elevated frequency of positive antineutrophilic cytoplasmic antibodies (ANCA) 13 in Uyghur patients, which might result from the differential genetic background of patients. Accordingly, novel potential biomarkers will help us further understand the causes of differential manifestations of UC in various ethnic groups.…”

Section: Introductionmentioning

confidence: 98%

Potential Biomarkers Associated with Differential Manifestations of Ulcerative Colitis (UC) in Uyghur and Han Population in China

Lu¹,

Maimaiti²,

Liu³

et al. 2021

JIR

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Background Ulcerative colitis (UC) is one of the main subtypes of inflammatory bowel disease (IBD). The incidence of UC in the Xinjiang region is relatively high in China and the manifestations of UC in Uyghur and Han patients are usually differential. This study aimed to identify potential biomarkers of UC. Methods All miRNA and mRNA were extracted from the tissue samples obtained from participants in Xinjiang. Differential expression analysis was performed on all mRNAs and miRNAs. The target genes of miRNAs were predicted via three databases. The clusterProfiler package was used for GO and KEGG pathway enrichment analysis. Results Preliminarily, four miRNAs and 15 genes were associated with the differential manifestations of UC in Uyghur and Han patients. Through the co-expression network construction and further screening in more samples, two miRNAs (hsa-miR-141-5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1 and SLC6A14) were found to be more crucial. These 15 genes were enriched in tight junction, NF-κB, and several other pathways. Conclusion Two miRNAs (hsa-miR-141-5p and hsa-miR-378a-5p) and three genes (ARNTL2, CLDN1, and SLC6A14) associated with the differential manifestations of UC in Uyghur and Han population were identified, which were potential biomarkers.

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Association of HLA‐DRB1 alleles and anti‐neutrophil cytoplasmic antibodies in Han and Uyghur patients with ulcerative colitis in China

Abstract: Genetic polymorphisms of the HLA-DRB108 and 13 may contribute to the clinical heterogeneity of UC between Uyghur and Han UC patients in China. In Uyghur UC patients, HLA-DRB1*13 may be correlated with ANCA positivity.

Cited by 7 publications

References 26 publications

Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China

Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China

Ethnic Difference of Disease Prevalence in Rural China: Examples and Explanations

Potential Biomarkers Associated with Differential Manifestations of Ulcerative Colitis (UC) in Uyghur and Han Population in China

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Association of HLA‐DRB1 alleles and anti‐neutrophil cytoplasmic antibodies in Han and Uyghur patients with ulcerative colitis in China

Abstract: Genetic polymorphisms of the HLA-DRB1*08 and *13 may contribute to the clinical heterogeneity of UC between Uyghur and Han UC patients in China. In Uyghur UC patients, HLA-DRB1*13 may be correlated with ANCA positivity.

Cited by 7 publications

References 26 publications

Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China

Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China

Ethnic Difference of Disease Prevalence in Rural China: Examples and Explanations

Potential Biomarkers Associated with Differential Manifestations of Ulcerative Colitis (UC) in Uyghur and Han Population in China

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Product

Resources

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Abstract: Genetic polymorphisms of the HLA-DRB108 and 13 may contribute to the clinical heterogeneity of UC between Uyghur and Han UC patients in China. In Uyghur UC patients, HLA-DRB1*13 may be correlated with ANCA positivity.