Association ofKCNQ1Polymorphisms with the Gestational Diabetes Mellitus in Korean Women

Shin, Hyoung Doo; Park, Byung Lae; Shin, Hui Jin; Kim, Jason Yongha; Park, Sunmin; Kim, Bowon; Kim, Sung Hoon

doi:10.1210/jc.2009-1393

Cited by 33 publications

(33 citation statements)

References 13 publications

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“…While we were preparing this paper, two similar reports regarding KCNQ1 and GDM were published [25,26]. The report of Shin et al [25] used our allele frequency data of the control subjects that was previously published [1].…”

Section: Discussionmentioning

confidence: 99%

“…The report of Shin et al [25] used our allele frequency data of the control subjects that was previously published [1]. However, the GDM group of Shin et al [25] was an independent population and our GDM group represented slightly more severe cases as it was diagnosed in more strict criteria. The two SNPs (rs2237892 and rs2237895) which were tested in all three studies showed similar allele frequencies, the same direction of association, as well as similar p values.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms in KCNQ1 Are Associated with Gestational Diabetes in a Korean Population

Kwak

Kim²,

Cho³

et al. 2010

Horm Res Paediatr

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Background: Recent genome-wide association studies in East Asians have identified polymorphisms in KCNQ1 as new type 2 diabetes risk variants. The aim of this study was to investigate whether variants in KCNQ1 are associated with development of gestational diabetes mellitus (GDM) and measures of oral glucose tolerance test (OGTT) at the time of diagnosis of GDM. Methods: Three candidate single nucleotide polymorphisms (rs2074196, rs2237892, and rs2237895) were genotyped in 869 Korean GDM women and 632 nondiabetic control subjects. Insulin resistance was estimated by homeostasis model assessment and pancreatic β-cell function by the insulinogenic index at 1 h. Results: rs2074196 and rs2237892 were associated with the risk of GDM (OR 1.17, 95% CI 1.01–1.36, p = 0.039; OR 1.24, 95% CI 1.07–1.45, p = 0.0049). Furthermore, rs2237892 and rs2237895 were nominally associated with a decreased insulinogenic index at the time of GDM diagnosis (p = 0.025 and p = 0.037), whereas no association was observed with measures of insulin resistance. Conclusions: The single nucleotide polymorphisms in KCNQ1 showed a significant association with GDM in the Korean population. Although the mechanism is not yet clear, it could be possible that variants in KCNQ1 confer a risk for GDM by altering pancreatic β-cell function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Polymorphisms in KCNQ1 Are Associated with Gestational Diabetes in a Korean Population

Kwak

Kim²,

Cho³

et al. 2010

Horm Res Paediatr

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“…The C allele of the rs2237892 was associated with GDM in two Korean studies (Kwak et al, 2010;Shin et al, 2010) but not in the Chinese study (Zhou et al, 2009). Instead, rs2237896 and rs2237895 were associated with GDM in a Chinese population (Zhou et al, 2009).…”

Section: Kcnq1mentioning

confidence: 77%

“…These genes have also been studied in women with GDM of various races, including Americans, Europeans, Mediterraneans, Asians, and Arabians. The number of women with GDM included in these studies ranged greatly from 25 (Low, Mohd Tohit, Chong, & Idris, 2010) to 930 (Shin et al, 2010). Sample size powered at least 80% was reported in only 6 of 24 studies (King, 2007;Lauenborg et al, 2009;Pappa et al, 2011;Shaat et al, 2005;Zhou et al, 2009).…”

Section: Resultsmentioning

confidence: 99%

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Shared Genomics of Type 2 and Gestational Diabetes Mellitus

Wung

Lin²

2011

Annu Rev Nurs Res

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Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and the prevalence of GDM is increasing worldwide. Short- and long-term complications of GDM on mothers and fetuses are well-recognized. These include more than seven-fold higher risk for type 2 diabetes mellitus (T2DM) later in life in women with GDM than those without. Evidence supports that GDM shares several risk factors with T2DM, including genetic risks. This chapter reviewed studies on candidate genes shared by T2DM and GDM published from 1990 to 2011. At least 20 susceptible genes of T2DM have been studied in women with GDM in various races. Results from current association studies on T2DM susceptible genes in GDM have shown significant heterogeneity There may be primary evidence that polymorphisms of susceptible genes of T2DM such as transcription factor 7-like 2 (TCF7L2) gene, potassium channel voltage-gate KQT-like subfamily member 1 (KCNQ1) gene, and cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) gene, may increase risk of GDM. Associations between GDM and many genetic variants have led to different findings across populations. Many genetic polymorphisms related to GDM were investigated in a single study or a single population. Replication studies to verify contributions of both common and rare genetic variants for GDM and T2DM in specific racial/ethnic groups are needed.

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Alterations of ATP-sensitive K+ channels in human umbilical arterial smooth muscle during gestational diabetes mellitus

Shin

Seo

et al. 2018

Pflugers Arch - Eur J Physiol

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We investigated the alterations of ATP-sensitive K (K) channels in human umbilical arterial smooth muscle cells during gestational diabetes mellitus (GDM). The amplitude of the K current induced by application of the K channel opener pinacidil (10 μM) was reduced in the GDM group than in the control group. Pinacidil-induced vasorelaxation was also predominant in the normal group compared with the GDM group. Reverse transcription polymerase chain reaction and Western blot analysis suggested that the expression of K channel subunits such as Kir6.1, Kir6.2, and SUR2B were decreased in the GDM group relative to the normal group. The application of forskolin and adenosine, which activates protein kinase A (PKA) and thereby K channels, elicited K current in both the normal and GDM groups. However, the current amplitudes were not different between the normal and GDM groups. In addition, the expression levels of PKA subunits were not altered between the two groups. These results suggest that the reduction of K current and K channel-induced vasorelaxation are due to the decreased expression of K channels, not to the impairment of K-related signaling pathways.

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Association ofKCNQ1Polymorphisms with the Gestational Diabetes Mellitus in Korean Women

Abstract: KCNQ1 polymorphisms shown to be associated with increased risk for T2DM in the recent GWA study might also represent genetic factors contributing to the development of GDM in Koreans.

Cited by 33 publications

References 13 publications

Polymorphisms in <i>KCNQ1</i> Are Associated with Gestational Diabetes in a Korean Population

Polymorphisms in <i>KCNQ1</i> Are Associated with Gestational Diabetes in a Korean Population

Shared Genomics of Type 2 and Gestational Diabetes Mellitus

Alterations of ATP-sensitive K+ channels in human umbilical arterial smooth muscle during gestational diabetes mellitus

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