Association ofIL-16gene polymorphisms with the risk of developing type 2 diabetes mellitus in the Chinese Han population

Abstract

Objective: The aim of the present study was to explore the genetic association of single nucleotide polymorphisms (SNPs) in interleukin-16 (IL-16) gene with type 2 diabetes mellitus (T2DM) susceptibility in a Chinese Han population. Methods: In total, 133 T2DM patients and 127 healthy controls matched by age and gender were recruited in the case–control study. IL-16 gene rs4778889 and rs11556218 polymorphisms were genotyped in the two groups via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Differences in genotype and allele distributions between groups were compared by the χ2 test. All the comparisons were adjusted for age, gender, and body mass index (BMI) by logistic regression. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association strength between IL-16 gene polymorphism and T2DM risk. Results: The TG genotype and G allele frequencies of rs11556218 increased remarkably in the case group than that in controls (45.86 vs 33.86%; 29.70 vs 20.87%), and the differences reached a significant level (P<0.05). After adjusting for age, gender, and BMI, the differences still reached a significant level (P<0.05). Rs11556218 TG genotype carriers had a 1.769-fold increased risk of developing T2DM (OR = 1.769, 95% CI = 1.045–2.994), and G allele was also associated with an increased risk of T2DM (OR = 1.639, 95% CI = 1.087–2.471). IL-16 rs4778889 polymorphism showed no significant association with T2DM risk. Conclusion: IL-16 gene rs11556218 polymorphism was significantly associated with T2DM susceptibility in the Chinese Han population, while rs4778889 was not.

Association of IL-16 rs11556218 T/G polymorphism with the risk of developing type 2 diabetes mellitus

“…Concomitant, under over dominant model, the presence of TG genotype had significant association with high risk of T2DM disease. A study on a Chinese Han population showed similar results that TG genotype was higher in diabetic patients than the control group (OR 1.7) [4]. As well as the risk of T2DM was higher in patients with G allele rs11556218 (OR = 1.639, 95 % CI = 1.087-2.471) which also like our results after adjusted them by risk factor of T2DM.…”

“…The triad of inflammation, obesity and insulin-resistance is shown in diabetes and metabolic syndrome [20]. IL-16 as a pro-inflammatory factor could be identified in several inflammatory diseases as allergic rhinitis and T2DM by stimulating of the secretion of different cytokines [4]. In this study, we are studying the association between IL16 rs11556218 T/G polymorphism and the risk of developing T2DM.…”

“…The neutralization of IL-16 may be a possible therapy for diabetes prevention [23]. Cheng et al hypothesized that the IL-16 gene polymorphism contributes to T2DM through altered levels of IL-16 expression or function [4].…”

“…Both the patients and their caregivers suffer due to the great economic burden of diabetes that is represented in treatments cost, complications managements, disability, and loss of productivity [3]. T2DM leads to a 2-4 folds increased risk of cardiovascular diseases and both microvascular and macrovascular complications have a great burden on the patients' health leading to multisystem affection and life threatening complications [4].…”

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

“…in Caucasians [47], diabetes mellitus [48], autoimmune diseases [49,50], endometriosis [45,51], and knee osteoarthritis [52,53]. A meta-analysis published in 2019 focusing only on renal cancer association studies also found no association between rs4778889 and rs11556218 and this disease [54].…”