Association of IL‐10‐1082A/G polymorphism with cardiovascular disease risk: Evidence from a case–control study to an updated meta‐analysis

Abstract

BackgroundPrevious studies have generated controversial results about the association of interleukin 10 (IL‐10) gene polymorphisms (−1082G/A) in the progression of cardiovascular disease (CVD). Therefore, this study processed a systemic meta‐analysis to verify this association.MethodsThe publication studies on the IL‐10 (−1082G/A) polymorphism and CVDs risk were obtained by searching PubMed and Embase databases. We analyzed the genotype data for meta‐analysis. The results were evaluated by odds ratios (ORs) and 95% confidence intervals (CIs). Meanwhile, our meta‐analysis was also performed sensitivity analyses, heterogeneity test, and identification of publication bias.ResultsThe present meta‐analysis suggested that the risk with allele G is lower than with allele A for CVD. The G allele of IL‐10 (−1082) could increase the risk of CVDs in the 31 case–control studies for all genetic models. (OR = 1.10, 95% CI: 1.04–1.15 for the allele model A vs. G; OR = 0.87, 95% CI: 0.72–1.04 for the dominant model GG+AG vs. AA; OR = 1.03, 95% CI: 1.02–1.05 for the recessive model GG vs. AG + AA; OR = 1.06, 95% CI = 1.03–1.10 for the homozygote comparison model GG vs. AA; and OR = 0.88, 95% CI = 0.73–1.06 for the heterozygote comparison model AG vs. AA).ConclusionsIn genetic models, the association between the IL‐10 (−1082G/A) polymorphism and CVDs risk was significant. This meta‐analysis proposes that the IL‐10 (−1082G/A) polymorphism may serve as a risk factor for CVDs.

Expresión de los componentes del inflamasoma y su relación con los marcadores de riesgo cardiovascular en personas con infección por HIV-1

“…Por otra parte, la expresión de la IL-10 fue significativamente menor en el grupo PT que en el P. En estudios previos, se ha demostrado que los niveles de esta citocina no guardan relación con la terapia antirretroviral combinada o el recuento de linfocitos T CD4+ 46 y, aunque se ha descrito su papel protector para evitar la formación de placas ateromatosas en modelos in vitro 47 , en estudios más recientes se ha asociado con un aumento del riesgo de enfermedades cardiovasculares 48 , 49 .…”