Association of <i>HTRA1</i> rs11200638 with age-related macular degeneration (AMD) in Brazilian patients

Lana, Tamires Prates; Costa, Sueli I. R.; Ananina, Galina; Hirata, Fábio Endo; Rim, Priscila Hae Hyun; Medina, Flávio Mac Cord; Vasconcellos, José Paulo Cabral de; Melo, Mônica Barbosa de

doi:10.1080/13816810.2017.1354382

Cited by 10 publications

(9 citation statements)

References 29 publications

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“…Another Chinese study showed a 7.6-fold increased risk in subjects with the A allele, with smoking status compounding the risk to 15.7fold [15]. Studies in Middle East [18], India [19], and Brazil [17] have shown similar results. Individuals with the AG and AA genotype have been found to have a 2.2-and 8.7-fold higher risk of developing AMD, respectively, when compared with those who carry the GG genotype [26].…”

Section: Discussionmentioning

confidence: 80%

“…Patients with the AA genotype were more prone to have AMD by nearly 26-fold. The association remained strong after data adjustment with [12,[17][18][19][22][23][24].…”

Section: Discussionmentioning

confidence: 90%

“…Replication studies on different ethnic populations show consistent results [7][8][9][10][11][12][13][14][15][16][17][18][19][20], but there are no reports on Indonesian populations. In addition to CFH and ARMS2 [3], no other genetics factors have been examined in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

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Association of the HtrA1 rs11200638 Polymorphism with Neovascular Age-Related Macular Degeneration in Indonesia

et al. 2021

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Introduction The aim of this study was to investigate the association of the HtrA1 rs11200638 polymorphism with neovascular age-related macular degeneration (nAMD) in Indonesia. Methods This case–control study included 80 patients with nAMD and 85 controls. Demographic parameters and whole blood were collected from each participant. Genomic DNA was extracted and used to assess the rs11200638 genotype by PCR and restriction enzyme digestion. Associations between the HtrA1 rs11200638 polymorphism and other risk factors for susceptibility to nAMD were assessed using the logistic regression model. Results Significant allelic associations between the HtrA1 polymorphism and nAMD were detected (odds ratio [OR] 8.67; 95% confidence interval [CI] 4.88–15.41; P < 0.001). Genotype analysis showed a statistical difference between the nAMD group and the control group ( P < 0.001). In the multiple adjusted logistic regression model, people with the AA genotype were more likely to have nAMD although there was a wide confidence interval (OR 19.65; 95% CI 4.52–85.38; P < 0.001). Conclusion Our findings show that the risk of nAMD increased in the presence of risk alleles of HtrA1 rs11200638.

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Section: Discussionmentioning

confidence: 80%

“…Patients with the AA genotype were more prone to have AMD by nearly 26-fold. The association remained strong after data adjustment with [12,[17][18][19][22][23][24].…”

Section: Discussionmentioning

confidence: 90%

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Association of the HtrA1 rs11200638 Polymorphism with Neovascular Age-Related Macular Degeneration in Indonesia

et al. 2021

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“…Finally, different genotype methods were applied in included studies, we tried to in each method, whether associations may exist in our analysis, we found some positive results in some methods (such as in AA vs. GG model: OR = 7.00, 95% CI = 5.84-8. 39, P heterogeneity = 0.677 about sequencing, Figure 7A; OR = 7.52, 95% CI = 2.05-27.68, P heterogeneity < 0.001, P = 0.002 about TaqMan; OR = 4.30, 95% CI = 2.51-7. 35, P heterogeneity = 0.073, Figure 7B) (Table 3).…”

Section: Subgroup Analysismentioning

confidence: 98%

High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjects

Liu¹,

Jin²,

Wei³

et al. 2020

Preprint

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Background The high-temperature requirement factor A1 (HTRA1) gene at the 10q26 locus has been associated with age-related macular degenerative (AMD) risk, with the significantly associated polymorphism being (rs11200638, -625G/A), however, above association is not consistent. We investigated an updated meta-analysis to evaluate the association between rs11200638 polymorphism and AMD risk thoroughly addressing this issue. Methods An identification was covered with the Pubmed and Chinese Wanfang databases through 27th Jan, 2020. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations. After a thorough and meticulous search, 35 different articles (33 case-control studies with HWE, 22 case-control studies about wet/dry AMD) were retrieved. Results Individuals carrying A-allele or AA genotype may have an increased risk to be AMD disease. For example, there has a significantly increased relationship between rs11200638 polymorphism and AMD both for Asians (OR: 2.50, 95%CI: 2.22-2.80 for A-allele vs. G-allele) and Caucasians (OR: 2.11, 95%CI: 1.43-3.13 for A-allele vs. G-allele). Moreover, a similar trend in the source of control subgroup was detected. To classify the type of AMD, increased association was also observed in both wet (OR: 3.40, 95%CI: 2.90-3.99 for dominant model) and dry (OR: 2.08, 95%CI: 1.24-3.48 for dominant model) AMD. Finally, based on the different genotyping methods, increased relationships were identified by sequencing, TaqMan, PCR-RFLP. Conclusions Our present meta-analysis suggests that the HTRA1 rs11200638 polymorphism are potentially associated with the risk of AMD development, especially about individuals carrying A-allele or AA genotype, who may be as identified targets to detect and intervene in advance. Further studies using larger sample sizes and including information about gene-environment interactions should be conducted to elucidate.

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“…Age-related macular degeneration (AMD) is a prevalent multifactorial disorder of the central retina and is the leading cause of vision loss in individuals over the age of 50. [1,2] AMD is divided into 2 basic clinical classification: early (visual symptoms are inconspicuous) and late (severe loss of vision is usual) 2 stages. [3] Based on the pathological features, AMD is classified into dry (nonexudative) and wet (exudative) 2 forms.…”

Section: Introductionmentioning

confidence: 99%

Associations of TLR4 gene polymorphisms with the risk of age-related macular degeneration in a Chinese Han population

Xiong²

2019

Medicine

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The study was designed to reveal the relationship of toll-like receptor 4 ( TLR4, rs1927914 and rs1927907) polymorphisms with risk of age-related macular degeneration (AMD), as well as the adjustment of this association by some environmental and lifestyle factors in Chinese Han population. TLR4 polymorphisms were genotyped by polymerase chain reaction-restricted fragment length polymorphisms and direct sequencing method in 138 AMD patients and 146 healthy controls. Genotype distribution in the control group was checked with Hardy–Weinberg equilibrium. Association of TLR4 polymorphisms and AMD risk was evaluated by χ 2 test and adjusted by age and sex, smoking and drinking. Odds ratio (OR) with 95% confidence interval (95% CI) was used to represent the association strength. Logistic regressive analysis was used to calculate the adjusted OR values. CC genotype of rs1927914 had significantly lower frequency in AMD patients ( P = .010), indicated a negative association with AMD risk (crude: OR = 0.358, 95% CI = 0.162–0.791; adjusted: OR = 0.355, 95% CI = 0.160–0.789). C allele of rs1927914 might decrease the susceptibility of AMD (crude: OR = 0.698, 95% CI = 0.497–0.982; adjusted: OR = 0.698, 95% CI = 0.495–0.984). No significant association has been discovered between TLR4 rs1927907 polymorphism and AMD susceptibility. Strong linkage disequilibrium existed between rs1927914 and rs1927907 polymorphisms. C-C haplotype was negatively associated with AMD risk (OR = 0.242, 95% CI = 0.121–0.485; OR = 0.242, 95% CI = 0.120–0.488). CC genotype and C allele of rs1927914 were significantly associated with the decreased AMD susceptibility.

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Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients

Cited by 10 publications

References 29 publications

Association of the HtrA1 rs11200638 Polymorphism with Neovascular Age-Related Macular Degeneration in Indonesia

Association of the HtrA1 rs11200638 Polymorphism with Neovascular Age-Related Macular Degeneration in Indonesia

High-temperature requirement factor A1 rs11200638 polymorphism and age-related macular degenerative from a comprehensive analysis about 15316 subjects

Associations of TLR4 gene polymorphisms with the risk of age-related macular degeneration in a Chinese Han population

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