Association of <i>Helicobacter pylori</i> infection with colorectal polyps and malignancy in China

Wang, Man; Kong, Wenjie; Zhang, Jing-Zhan; Lu, Jiajie; Hui, Wenjia; Liu, Weidong; Kang, Xiaojian; Gao, Feng

doi:10.4251/wjgo.v12.i5.582

Cited by 18 publications

(20 citation statements)

References 44 publications

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“…Colorectal adenomatous polyps are considered the most important precancerous lesions that develop into colorectal cancer through the adenomatous carcinoma sequence. Therefore, early screening, early detection, and early treatment of precancerous lesions can prevent the occurrence and development of colorectal cancer[ 81 , 82 ]. Although the incidence of SBC is high in CD patients, the relationship between CD and colorectal cancer is controversial.…”

Section: And Colorectal Cancermentioning

confidence: 99%

Association between intestinal neoplasms and celiac disease: A review

Wang¹,

Yu²,

Kong³

et al. 2021

WJGO

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Celiac disease (CD) is a chronic immune-mediated intestinal disease with genetic susceptibility. It is characterized by inflammatory damage to the small intestine after ingestion of cereals and products containing gluten protein. In recent years, the global prevalence rate of CD has been approximately 1%, and is gradually increasing. CD patients adhere to a gluten-free diet (GFD) throughout their entire life. However, it is difficult to adhere strictly to a GFD. Untreated CD may be accompanied by gastrointestinal symptoms, such as diarrhea, abdominal pain, and extraintestinal symptoms caused by secondary malnutrition. Many studies have suggested that CD is associated with intestinal tumors such as enteropathy-associated T-cell lymphoma (EATL), small bowel cancer (SBC), and colorectal cancer. In this study, we reviewed related studies published in the literature to provide a reference for the prevention and treatment of intestinal tumors in patients with CD. Compared with the general population, CD patients had a high total risk of SBC and EATL, but not colorectal cancer. The protective effect of GFD on CD-related malignancies is controversial. Further studies are needed to confirm whether GFD treatment can reduce the risk of intestinal neoplasms in CD.

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Section: And Colorectal Cancermentioning

confidence: 99%

Association between intestinal neoplasms and celiac disease: A review

Wang¹,

Yu²,

Kong³

et al. 2021

WJGO

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“…Four recent meta-analyses demonstrated a positive association between H. pylori infection and the risk of CRC and colorectal adenoma, presenting OR (95%CI) varying from 1. 27 (8)(9)(10)(11) (TABLE 1). The studies involved in these meta-analyses came from 16 countries situated in Asia (38%), Europe (33%), America (mostly the USA) (20%), Middle-East (7%), and Oceania (2%).…”

Section: Helicobacter Pylori and Colorectal Neoplasms: A Concise Review Potential Associations Among H Pylori Infection And Colorectal Nementioning

confidence: 99%

“…The results showed that advanced colonic neoplasms occurred more frequently in H. pylori-infected patients with atrophic gastritis than without atrophic gastritis (7.3% vs 4.4%, P<0.001). A large recent study also investigated the association of gastric H. pylori presence with the risk of colorectal polyps and CRC (27) . The results confirmed that patients with H. pylori infection were 2.19 and 3.05 times more likely to develop colorectal polyps and CRC, respectively, than those without H. pylori active infection.…”

Section: H Pylori Infectionmentioning

confidence: 99%

“…Biological gradient: the presence of a dose-response effect traditionally supports a causal relationship between an agent and the effect. Some studies suggest that patients infected with H. pylori strains expressing gastric cancer virulence factors such as cagA and vacA, or presenting premalignant gastric lesions have higher odds of association with CRC (19,20,27,57) . Biological plausibility and coherence: these criteria seek to analyze whether the relationship between the agent and the…”

Section: Orcidmentioning

confidence: 99%

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Helicobacter pylori and colorectal neoplasms: a concise review

Coelho

2021

Arq. Gastroenterol.

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Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and lymphoma. Epidemiological and experimental studies suggest that H. pylori chronic infection may be related to different extragastric diseases, including colorectal neoplasms. This concise review aims to explore the association of H. pylori infection with colorectal cancer and adenoma, including the recent epidemiological findings, the diagnostic methods employed to detect H. pylori and virulent factors, and the potentially involved mechanisms. Furthermore, is attempted to establish the current data integration for causal inference using the Bradford-Hill causality criteria. The weak, although global, strength of the epidemiological positive association between H. pylori infection and colonic neoplasms associated to new mechanisms postulated to explain this interaction, including intestinal dysbiosis, should stimulate future studies. Prospective confirmatory studies to establish the role of H. pylori eradication in the process of carcinogenic transformation of the colonic epithelium may define its eventual role in the treatment and prevention of colonic neoplasms.

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“…In addition, studies investigating the association between gastric IM and colorectal adenomas were also conducted [12,20]. A recent study reported that there is a significant relationship between gastric intestinal metaplasia and colorectal neoplasia [21]. The aim of this study was to evaluate the relationship between H. pylori infection and IM, which is considered a premalignant lesion for gastric cancer, with colon neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Is gastric intestinal metaplasia a risk factor for colorectal neoplasms?

Beştaş

Ekin

2021

Biotechnology & Biotechnological Equipment

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Colorectal cancers are one of the most common types of cancer. Gastric intestinal metaplasia is considered a precancerous lesion that can progress into gastric cancer. Even though there are previous reports that Helicobacter pylori and intestinal metaplasia are related to colorectal adenomas, there are also studies stating the opposite. This study aimed explored the relationship between gastric intestinal metaplasia and colorectal neoplasia. A total of 214 patients between the ages of 19 and 92 who underwent combined gastroscopy and colonoscopy between August 2016 and April 2020 were included in this retrospective study. Medical records including demographic data, gastroscopy and colonoscopy findings and histopathology results of the patients were reviewed and analyzed. The association of intestinal metaplasia and H. pylori infection with colorectal neoplasia was evaluated in these patients. The mean age of the patients included in the study was 49.07 ± 15.80, and 125 (58.4%) of the patients were male. A statistically significant correlation was found between intestinal metaplasia and colon neoplasm prevalence (p = 0.03). However, such a correlation was not seen between H. pylori and colon neoplasia. In conclusion, a positive correlation was found between gastric intestinal metaplasia, which is a precancerous lesion, and colon neoplasia. Even though this correlation indicates higher prevalence rates of colon neoplasia in patients with gastric intestinal metaplasia, how to evaluate these patients in terms of colon neoplasia remains a controversial issue.

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Association of Helicobacter pylori infection with colorectal polyps and malignancy in China

Cited by 18 publications

References 44 publications

Association between intestinal neoplasms and celiac disease: A review

Association between intestinal neoplasms and celiac disease: A review

Helicobacter pylori and colorectal neoplasms: a concise review

Is gastric intestinal metaplasia a risk factor for colorectal neoplasms?

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