Association of Helicobacter pylori‐dependent gastritis with gastric carcinomas in young Japanese patients: histopathological comparison of diffuse and intestinal type cancer cases

Abstract

As well as the high prevalence of H. pylori in young subjects with gastric cancer, it is clear that persistent infection induces mucosal damage, resulting in atrophy and intestinal metaplasia. Thus, acute/chronic gastritis could play an essential role in the early development of neoplasia in the stomach.

Intramucosal gastric adenocarcinoma of poorly differentiated type in the young is characterized by Helicobacter pylori infection and antral lymphoid hyperplasia

“…With regard to glandular atrophy and intestinal metaplasia of the background mucosa, our young patients were mostly infected by H. pylori, however, they had less degree of corporal glandular atrophy and less frequent intestinal metaplasia around the intramucosal gastric cancer than elderly patients did. This result is consistent with that of the previous report by Mori et al 2 On the other hand, Koshida et al 18 reported that there was significantly higher prevalence of H. pylori infection, glandular atrophy and intestinal metaplasia in cases with gastric cancer than in cases without gastric cancer in young patients. This result is not consistent with the above ones including ours, however, Koshida et al 18 treated with patients younger than 40 years old (total of 40 patients, including only nine patients under 30 years of age).…”

“…Our patients under 30 years old were much younger than those of other reports, which dealt the age of under 40 [9][10][11][12]15,18 or 35 13,14 years as the young group. Therefore, our present materials are considered to be more suitable for analysis of carcinogenesis of cancer in young patients.…”

“…In several studies, the clinicopathological features of gastric cancer in the young were somewhat different from ours. 1,2,[9][10][11][12][13][14]3,[15][16][17][18][19] With regard to histological type, poorly differentiated adenocarcinoma tends to be more frequent in young adults, [12][13][14]3 however, there is no difference in sex distribution between the young and elderly patients. 9,10,13,14 The discrepancy (b) Fifty-seven-year-old male subject (same case as a).…”

“…The prevalence of H. pylori infection has already been reported to have relevance to gastric cancer in young patients. [15][16][17][18][19] Haruma et al 16 reported that the prevalence of H. pylori infection was higher in patients under 30 years of age with gastric cancer than in age-and sex-matched controls without gastric cancer. In addition, they also mentioned that the prevalence was not associated with tumor location, tumor stage or histological type.…”

Helicobacter pylori infection, but not genetic polymorphism of CYP2E1, is highly prevalent in gastric cancer patients younger than 40 years

“…Longterm infection with H. pylori has been reported to result in H. pylori-associated chronic atrophic gastritis, which has been shown to correlate closely with gastric cancer, especially in young adults [16][17][18][19]. The endoscopic characteristics of H. pylori-associated gastritis in young adults have revealed nodular, rugal hyperplastic, and chronic atrophic gastritis to be specifi c to patients with H. pylori infection [20].…”