Association of<i>Fusobacterium</i>species in pancreatic cancer tissues with molecular features and prognosis

Mitsuhashi, Kei; Nosho, Katsuhiko; Sukawa, Yasutaka; Matsunaga, Yasutaka; Ito, Miki; Kurihara, Hideo; Kanno, Satoshi; Igarashi, Harukazu; Naito, Takafumi; Adachi, Yasushi; Tachibana, Mami; Tanuma, Tokuma; Maguchi, Hiroyuki; Shinohara, Toshiya; Hasegawa, Tadashi; Imamura, Masafumi; Kimura, Yasutoshi; Hirata, Koichi; Maruyama, Reo; Suzuki, Hiromu; Imai, Kohzoh; Yamamoto, Hiroyuki; Shinomura, Yasuhisa

doi:10.18632/oncotarget.3109

Cited by 295 publications

(278 citation statements)

References 49 publications

(87 reference statements)

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“…Among proposed mechanisms for dissemination may result from hepatobiliary translocation or hematogenous seeding[44,46]. However, DNA of different Helicobacter species is mutually exclusive by sampled site[44].…”

Section: Resultsmentioning

confidence: 99%

Microbiome and pancreatic cancer: A comprehensive topic review of literature

Ertz-Archambault

Keim

Hoff

2017

WJG

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AIMTo review microbiome alterations associated with pancreatic cancer, its potential utility in diagnostics, risk assessment, and influence on disease outcomes.METHODSA comprehensive literature review was conducted by all-inclusive topic review from PubMed, MEDLINE, and Web of Science. The last search was performed in October 2016.RESULTSDiverse microbiome alterations exist among several body sites including oral, gut, and pancreatic tissue, in patients with pancreatic cancer compared to healthy populations.CONCLUSIONPilot study successes in non-invasive screening strategies warrant further investigation for future translational application in early diagnostics and to learn modifiable risk factors relevant to disease prevention. Pre-clinical investigations exist in other tumor types that suggest microbiome manipulation provides opportunity to favorably transform cancer response to existing treatment protocols and improve survival.

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Section: Resultsmentioning

confidence: 99%

Microbiome and pancreatic cancer: A comprehensive topic review of literature

Ertz-Archambault

Keim

Hoff

2017

WJG

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“…Species from the phylum Fusobacteria (particularly F. nucleatum ) are commonly observed in the oral cavity of individuals with periodontal disease, and recent mechanistic evidence has linked F. nucleatum to carcinogenesis 32 . Thus, as suggested by epidemiologic links between the oral microbiota and pancreatic cancer development 33,34 , it may be that Fusobacterium contributes to pancreatic cancer pathogenesis in some patients.…”

Section: Discussionmentioning

confidence: 99%

Disturbances of the Perioperative Microbiome Across Multiple Body Sites in Patients Undergoing Pancreaticoduodenectomy

et al. 2017

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Objective The goal of this study was to characterize bacterial communities within fecal samples, pancreatic fluid, bile, and jejunal contents from patients undergoing pancreaticoduodenectomy (PDA), and to identify associations between microbiome profiles and clinical variables. Methods Fluid was collected from the pancreas, common bile duct, and proximal jejunum from 50 PDA patients. Postoperative fecal samples were also collected. The microbial burden within samples was quantified with ddPCR. Bacterial 16S ribosomal RNA gene sequences were amplified, sequenced, and analyzed. Data from fecal samples were compared to publicly available data obtained from volunteers. Results ddPCR confirmed the presence of bacteria in all sample types, including pancreatic fluid. Relative to samples from the American Gut Project, fecal samples from PDA patients were enriched with Klebsiella and Bacteroides, and were depleted of anaerobic taxa (e.g. Roseburia and Faecalibacterium). Similar patterns were observed within PDA pancreas, bile, and jejunal samples. Postoperative fecal samples from patients with a pancreatic fistula contained increased abundance of Klebsiella and decreased abundance of commensal anaerobes, e.g. Ruminococcus. Conclusions This study confirms the presence of altered bacterial populations within samples from PDA patients. Future research must validate these findings and may evaluate targeted microbiome modifications to improve outcomes in PDA patients.

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“…As reported by Mitsuhashi et al (2015), bacteria can reach the pancreas through circulation, and it has been suggested that this occurs through the biliary tract (transductal transmission) (Zambirinis et al, 2014) to act synergistically with other risk factors, such as obesity and smoking, among others, during carcinogenesis.…”

Section: Pancreatic Cancermentioning

confidence: 96%

“…Furthermore, an estimated 93 283 people are expected to die of this disease. Pancreatic cancer is an aggressive malignancy, with a low rate of survival and therapeutic success (Mitsuhashi et al, 2015;Pevsner-Fischer et al, 2016). Therefore, it is important to further understand its pathogenesis and to search for new diagnostic and therapeutic alternatives (Mitsuhashi et al, 2015;Zambirinis et al, 2014).…”

Section: Pancreatic Cancermentioning

confidence: 99%

Microbiota dysbiosis: a new piece in the understanding of the carcinogenesis puzzle

García-Castillo

Sanhueza

McNerney

et al. 2016

Journal of Medical Microbiology

102

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Cancer is defined as an uncontrolled proliferation of malignant cells in a host and it is one of the main causes of death worldwide. Genetic and environmental factors play an important role in its development, and the involvement of microbial communities has also recently been recognized. The close relationship that characterizes the colonization by human commensal communities involves health risks, particularly when the homeostasis is disturbed. It has been hypothesized that this process may lead to cancer by modulating the inflammatory response of the host, by the production of carcinogenic metabolic products or by the production of toxins, which disrupt the cell cycle. The metabolic effects of the intestinal microbiota have been studied in greater detail in the gastrointestinal tract, and it has been recognized that microbial communities of other body surfaces can cause effects either locally or at a distance. In vitro and in vivo studies have allowed the characterization of the microbiota and the establishment of a cause and effect relationship with some types of cancer. Nevertheless, despite the results, representative studies are necessary to validate the findings and definitively establish the role of microbiota in cancer development in order to open the possibility of promising therapeutic and diagnostic applications. Thus, the aims of this review are to briefly examine the available evidence, and to analyse the mechanisms described for pancreatic, lung, colorectal cancer , oral squamous cell carcinoma and hepatocellular carcinoma and the impact of the current knowledge about the effects of the microbiota on carcinogenesis.

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Association ofFusobacteriumspecies in pancreatic cancer tissues with molecular features and prognosis

Cited by 295 publications

References 49 publications

Microbiome and pancreatic cancer: A comprehensive topic review of literature

Microbiome and pancreatic cancer: A comprehensive topic review of literature

Disturbances of the Perioperative Microbiome Across Multiple Body Sites in Patients Undergoing Pancreaticoduodenectomy

Microbiota dysbiosis: a new piece in the understanding of the carcinogenesis puzzle

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