Association ofCYP2C9Genetic Variants with Vitiligo

Alzolibani, Abdullateef A.; Robaee, Ahmad A. Al; Al‐Shobaili, Hani A.; Alsaif, Fahad; Al-Mekhadab, Eman; Settin, Ahmad

doi:10.5021/ad.2014.26.3.343

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…The increase in the frequency of isolates of S. aureus resistant to β-lactam antibiotics has been reported in the literature since the beginning of its clinical use in 1940 (Livermore, 2000). Alzolibani et al (2012) found 96.7% ampicillin resistance in clinical isolates of S. aureus, which agrees with the data obtained in our study.…”

Section: Resultssupporting

confidence: 83%

“…Similarly, Kowalski et al (2003) suggest that S. aureus had increased susceptibility to fourth generation fluoroquinolones. In contrast, other studies revealed high frequency of resistance to ciprofloxacin (Alzolibani et al, 2012;Flamm et al, 2012;Kwak et al, 2013). A possible explanation for this discrepancy could be that the isolates tested in this study were collected in the late 70s and early 80s prior to the introduction of fluoroquinolones to clinical use.…”

Section: Resultscontrasting

confidence: 45%

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Antibacterial activity of different types of snake venom from the Viperidae family against Staphylococcus aureus

Canhas¹,

Heneine²,

Fraga³

et al. 2017

Acta Sci. Biol. Sci.

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ABSTRACT. Toxins and venoms produced by living organisms have exhibited a variety of biological activities against microorganisms. In this study, we tested seven snake venoms from the family Viperidae for antibacterial activity and the activities of reversal of antibiotic resistance and inhibition of biofilm formation against 22 clinical isolates of Staphylococcus aureus. Bothrops moojeni venom exhibited anti staphylococcal activity with the lowest mean value of minimum inhibitory concentration (MIC). Moreover, reversal of antibiotic resistance was observed for combinations of B. moojeni venom (½ x MIC) and norfloxacin or ampicillin (both ½ x MIC) for 86.4% and 50% of the isolates, respectively. B. moojeni venom alone at ½ MIC inhibited 90% of biofilm formation, whereas in combination with ciprofloxacin, both at ½ MIC, a reduction on the NorA efflux pump activity was observed. The detection of in vitro mutants colonies of S. aureus resistant to B. moojeni venom was low and they did not survive. A phospholipase A2 was purified from the venom of B. moojeni and displayed anti-staphylococcal activity when tested alone or in combination with ciprofloxacin. The results presented here will contribute to the search for new antimicrobial agents against resistant S. aureus.

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Section: Resultssupporting

confidence: 83%

Section: Resultscontrasting

confidence: 45%

Antibacterial activity of different types of snake venom from the Viperidae family against Staphylococcus aureus

Canhas¹,

Heneine²,

Fraga³

et al. 2017

Acta Sci. Biol. Sci.

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“…Third, the results of the Egger tests revealed the possibility of a significant publication bias in this meta-analysis. Moreover, vitiligo may also be modulated by several other genetic markers other than TNF-α, such as CYP2C9 (Alzolibani et al, 2014), PTPN22 (Garcia-Melendez et al, 2014), and ACE (Badran et al, 2015). Therefore, the results of our metaanalysis emphasize the need for further evaluation of the potential gene-gene interactions in vitiligo, in order to elucidate the pathogenesis of vitiligo.…”

Section: Discussionmentioning

confidence: 89%

Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk

Nie¹,

Jh²,

Cw³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Several case-control studies have been conducted to investigate the association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and vitiligo risk. However, the results of these studies are inconsistent; therefore, we attempted to comprehensively evaluate the association between TNF-α-308G/A polymorphism and vitiligo risk via a meta-analysis. Studies reporting the association between TNF-α-308G/A polymorphism and vitiligo risk were retrieved from PubMed and EmBase databases. Data were extracted from these studies and the pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association. Six case-control studies including 1391 vitiligo cases and 2455 control subjects were included in this meta-analysis. The overall results showed the lack of a significant difference in TNF-α-308G/A genotype distribution between the patients and controls when the G allele and GG, GG + GA, GG, and GG genotypes were compared against the A allele and the GA + AA, AA, AA, and GA genotypes, respectively (ORs = 0.65, 0.53, 0.63, 0.41, 0.55; P = 0.188, 0.121, 0.627, 0.264, 0.135, respectively). This meta-analysis suggests that the TNF-α-308G/A polymorphism may not be associated with vitiligo risk. As few studies are available in this field and current evidence remains limited, these results must be corroborated with well-designed and larger studies in the future.

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“…Female predominance is seen in the present study (62% vs. 38%), similar to the results in studies done by Jaisankar et al and Al-Jabari et al 1,2 Studies with male predominance were not found among children in contrast to that among adults (Shankar et Kar [51.6%]). [3][4][5][6] So, there is more concern amongst parents in India when a girl is developing depigmented lesion than a boy as cosmetic appearance and related social and marital problems are more among girls in Indian structure.…”

Section: Discussionmentioning

confidence: 99%

Childhood Vitiligo: A hospital based retrospective study in Coastal South India

Davda¹,

Sivasubramanian²

2020

IJCED

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Vitiligo is an acquired, multifactorial disorder of depigmentation and is overwhelming and distressing to the patients and the care givers. Childhood vitiligo has different characteristics as compared to adult-onset vitiligo. Every parent wants to know if the disease will progress or regress. To study the epidemiological, clinical and hematological patterns of children with vitiligo. First 50 patients with vitiligo, younger than 12 years of age, who visited the Dermatology outpatient department of Vinayaka Missions Hospital, a tertiary care center in Karaikal, between January 2015 and January 2020 were included. They were assessed for the natural history, clinical features, family history and associated abnormalities of vitiligo. There were 19 boys and 31 girls (boys: girls 1:1.63) out of 50 patients. Mean age of onset of vitiligo was 5.8 years and mean duration was 1.4 years. The most common site was the head and the neck, followed by the extremities, trunk and genitalia and the most prevalent type was vitiligo vulgaris (60%). Then, it was acrofacial vitiligo (26.5%), focal vitiligo (23.7%) and segmental vitiligo (2.6%). 5 patients had a positive family history. Involvement of mucosa in 12%, Leukotrichia in 11% and Koebnerization was seen in 10% children. Body involvement is bilateral in 72% and unilateral in 28% children. Majority of patients (49%) had multiple lesions (more than 5) and most (96%) had <5% body surface area involved. In children, any depigmented/hypopigmented lesion should be evaluated and followed up properly to rule out vitiligo. The patterns and characteristics of childhood-onset vitiligo should be understood properly by Dermatologists as it presents in a different manner from adult-onset disease and its management should take several factors into consideration like extension, psychological effects on children and parents, avoidance of treatment side effects and probable association with other autoimmune diseases.

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Association ofCYP2C9Genetic Variants with Vitiligo

Cited by 4 publications

References 38 publications

<b>Antibacterial activity of different types of snake venom from the Viperidae family against <i>Staphylococcus aureus

<b>Antibacterial activity of different types of snake venom from the Viperidae family against <i>Staphylococcus aureus

Meta-analysis of the TNF-α-308G/A polymorphism and vitiligo risk

Childhood Vitiligo: A hospital based retrospective study in Coastal South India

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