Association ofCampylobacter pylorion the Gastric Mucosa with Antral Gastritis in Children

Abstract

We investigated the presence of Campylobacter pylori colonization of the gastric mucosa and of histologic evidence of gastritis in a prospective study of 71 consecutive children undergoing upper gastrointestinal tract endoscopy and gastric biopsies because of gastrointestinal symptoms. Two tissue samples from the gastric antrum were obtained from 67 of the 71 children (mean age [+/- SD], 11.4 +/- 3.8 years). One sample was evaluated for evidence of gastritis and stained with silver to detect organisms morphologically resembling campylobacter. The second sample was cultured for C. pylori, and a portion was used to perform a urease-screening test for the presence of C. pylori. Antral gastritis was diagnosed histologically in 18 of 67 patients. C. pylori was identified by both culture and silver staining on the antral mucosa in 7 of 10 patients with unexplained gastritis (primary gastritis) but in none of 8 patients with gastritis associated with an identifiable underlying cause (secondary gastritis). C. pylori was not identified in any of the 49 cases with normal histologic features. The urease-screening test was positive in only three of six patients with a positive culture for C. pylori. Duodenal ulcers were diagnosed by endoscopy in five patients. Each of the five had C. pylori on the antral mucosa, but organisms were not identified on the duodenal mucosa. We conclude that the presence of C. pylori on the antral mucosa is specifically associated with primary antral gastritis and may also be associated with primary duodenal ulceration.

Comparison of the Prevalence of Helicobacter pylori Infection Between the Exclusively Breastfed and Formula- or Mixed-Fed Infants in the First Six Months of Life

“…Helicobacter pylori are among the most common human gastrointestinal pathogens with worldwide spread in both children and adults (1)(2)(3). It is a Gram-negative Sshaped bacillus producing urease, catalase, and oxidase and these enzymes may play an important role in the pathogenesis of the microorganism in peptic ulcer disease (4).…”

“…Urea breathing test with C13 and stool antigen tests are the non-invasive methods to diagnose H. pylori infection (4). According to the literature, H. pylori infection is an important risk factor for developing chronic active gastritis, peptic ulcer disease, and even gastric CA (1,2,5). Most of the infected people get it during childhood (6)(7)(8).…”

Pyloric Narrowing with Increased Fibrous Tissue of the Mucosa in an Infant.

“…The mucosal histology is thought to be nonspecific, different from eosinophilic gastroenteritis and Helicobacter pylori-positive gastritis (Drumm et al 1987 ; Kilbridge et al 1988). It remains unclear whether or not the mucosal inflammation and fibrous change were secondary to frequent bilious vomiting.…”

Helicobacter Pylori Infection And Benign Gastroduodenal Diseases, Data From Trakya Region

“…[1][2][3][4][5] Almost half of the world's population is thought to be infected with this bacteria. [6] It is estimated that perhaps as many as 5-15% of individuals may develop peptic ulceration during their lives, while as many as 1 in 100 may develop gastric adenocarcinoma.…”