Association ofBSGgenetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population

Abstract

The Basigin (BSG, also known as CD147/extracellular matrix metalloproteinase inducer) belongs to the immunoglobulin superfamily (IgSF). It is a cellular receptor for cyclophilin A (CypA), and is originally known as tumor cell collagenase stimulatory factor (TCSF), which could abundantly expressed on the surface of tumor cells, haematopoietic, monocytes, epithelial endothelial cells and smooth muscle cells. Accumulating evidence showed that BSG played an important role in stimulating the secretion of matrix metalloproteinases (MMPs), which has been reported to be involved in the development of atherosclerosis. Since atherosclerosis is an important risk factor for atherosclerotic cerebral infarction (ACI), we speculate that BSG genetic polymorphisms may influence formation of atherosclerosis and then development of ACI. This study aimed to detect the potential association of the single nucleotide polymorphisms (SNP, -631 G > T, -318 G > C, 10141 G > A and 10826 G > A) of BSG gene in Hunan Han Chinese population with ACI. We genotyped 199 ACI patients and 188 matched healthy controls for the four BSG SNP by method of matrix-assisted laser desorption/ionization-time-offlight mass spectrometry (MALDI-TOF MS). Our results suggested that all the polymorphisms were observed in the subjects from Changsha area of Hunan Province. However, no significant difference was observed between the distribution of these SNP in cases and controls. Therefore, we speculate that BSG genetic polymorphisms might not be an important factor in the development of ACI in our Chinese Han population.

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

“…CD147 also plays an essential role in germ cell migration and survival/apoptosis during spermatogenesis [14]. In acute coronary syndrome patients with unstable coronary artery plaques, CD147 expression is increased on macrophages (Mφ) and smooth muscle cells, but CD147 genetic polymorphisms are not an important factor in atherosclerotic cerebral infarction in the Han Chinese population [133,134]. CD147 is also associated with the formation of brain edema induced by subarachnoid hemorrhage (SAH) in the monofilament puncture model of male Sprague–Dawley rats [19], but the direct role of CD147 and its mechanism of action in SAH need further study.…”

Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans

“…To our knowledge, this is the first report on genetic variation in the NECTIN4 or BSG genes in Cetaceans, while polymorphisms of the BSG gene, although not related to morbilliviruses, were observed in other mammalian species . No associations of NECTIN4 or BSG polymorphisms with morbillivirus infection have been reported so far.…”

The APOE promoter polymorphism is associated with rebleeding after spontaneous SAH in a Chinese population

“…Some researchers tried exploring heritable components to explain the individual differences of rebleeding (Kissela et al, 2002;Zhou et al, 2014).…”