2008
DOI: 10.1038/oby.2008.344
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Association of ADIPOR2 With Liver Function Tests in Type 2 Diabetic Subjects

Abstract: Objective: Adiponectin protects against liver dysfunction in insulin-resistant states such as obesity and type 2 diabetes (T2DM), but the role of adiponectin receptors in this disorder is largely unknown. We studied whether common single-nucleotide polymorphisms (SNPs) in ADIPOR1 and ADIPOR2 are associated with liver function tests (LFTs) in human subjects with various degrees of insulin resistance. Methods and Procedures: Serum alanine (ALT) and aspartate (AST) aminotransferases, homeostasis model assessment … Show more

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Cited by 13 publications
(7 citation statements)
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“…SNPs in genes encoding peroxisome proliferator-activated receptor g coactivator 1 a (28), adiponutrin (29), CLOCK transcription factor (30), PPARD (10), and upstream transcription factor 1 (13) have recently been shown to be related to variation in liver fat content in humans. Two polymorphisms in ADIPOR2 (K64,241 T/G and C33447 C/T) were shown to be associated with serum ALT and AST concentrations in patients with type 2 diabetes, but not in non-diabetic subjects (31). In addition, loci on chromosomes 10 (CPN1-ERLIN1-CHUK) and 22 (PNPLA3-SAMM50) were associated with ALT concentrations, and a locus on chromosome 12 (HNF1A) with gGT concentrations (32) in individuals from the general population.…”
Section: Discussionmentioning
confidence: 99%
“…SNPs in genes encoding peroxisome proliferator-activated receptor g coactivator 1 a (28), adiponutrin (29), CLOCK transcription factor (30), PPARD (10), and upstream transcription factor 1 (13) have recently been shown to be related to variation in liver fat content in humans. Two polymorphisms in ADIPOR2 (K64,241 T/G and C33447 C/T) were shown to be associated with serum ALT and AST concentrations in patients with type 2 diabetes, but not in non-diabetic subjects (31). In addition, loci on chromosomes 10 (CPN1-ERLIN1-CHUK) and 22 (PNPLA3-SAMM50) were associated with ALT concentrations, and a locus on chromosome 12 (HNF1A) with gGT concentrations (32) in individuals from the general population.…”
Section: Discussionmentioning
confidence: 99%
“…The role of the major adiponectin receptor gene, i.e., adiponectin receptor 2 (AdipoR2), has been linked to insulin resistance and type 2 diabetes, where it plays a crucial role in glucose and lipid metabolism, inflammation and oxidative stress [ 143 ]. In a study on rats [ 109 ], the probiotic Lactobacillus casei Zhang also increased the expression of AdipoR2 in fat cells.…”
Section: Effect Of Probiotics On Glucose Metabolism and Homeostasismentioning
confidence: 99%
“…Furthermore, certain single nucleotide polymorphisms (SNPs) in the AdipoR2 gene, such as rs1342387, rs1063538, rs266729 and rs1862513, may be associated with CRC risk ( 6 , 13 15 ). In addition, rs10773989 and rs1044471 in the AdipoR2 gene have been reported to be associated with various types of disease, such as type 2 diabetes, and prostate and gastric cancer ( 16 18 ). However, such associations between the SNPs in AdipoR2 and CRC remain controversial ( 19 , 20 ).…”
Section: Introductionmentioning
confidence: 99%