Association of<i>ABCB1</i>C3435T polymorphism with phenobarbital resistance in Thai patients with epilepsy

Keangpraphun, T.; Towanabut, Somchai; Chinvarun, Yotin; Kijsanayotin, Pornpimol

doi:10.1111/jcpt.12263

Cited by 23 publications

(20 citation statements)

References 39 publications

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“…1 ). Only 13 met the inclusion criteria and constituted the data set for this analysis [ 22 – 29 , 31 , 33 – 36 ] (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…The included studies were heterogeneous for the study characteristics. The analysis of data showed that 454 of 1653 AEDs-resistant patients (27.465%) and 282 of 1732 AEDs-responsive patients (16.282%) were included in the statistical analysis [ 22 – 29 , 31 , 33 – 36 ]. The frequency of AEDs-resistant cases was higher than AEDs-responsive patients.…”

Section: Resultsmentioning

confidence: 99%

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Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis

et al. 2017

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BackgroundAntiepileptic drugs (AEDs) are effective medications available for epilepsy. However, many patients do not respond to this treatment and become resistant. Genetic polymorphisms may be involved in the variation of AEDs response. Therefore, we conducted an updated systematic review and a meta-analysis to investigate the contribution of the genetic profile on epilepsy drug resistance.MethodsWe proceeded to the selection of eligible studies related to the associations of polymorphisms with resistance to AEDs therapy in epilepsy, published from January 1980 until November 2016, using Pubmed and Cochrane Library databases. The association analysis was based on pooled odds ratios (ORs) and 95% confidence intervals (CIs).ResultsFrom 640 articles, we retained 13 articles to evaluate the relationship between ATP-binding cassette sub-family C member 1 (ABCB1) C3435T polymorphism and AEDs responsiveness in a total of 454 epileptic AEDs-resistant cases and 282 AEDs-responsive cases. We found a significant association with an OR of 1.877, 95% CI 1.213–2.905. Subanalysis by genotype model showed a more significant association between the recessive model of ABCB1 C3435T polymorphism (TT vs. CC) and the risk of AEDs resistance with an OR of 2.375, 95% CI 1.775–3.178 than in the dominant one (CC vs. TT) with an OR of 1.686, 95% CI 0.877–3.242.ConclusionOur results indicate that ABCB1 C3435T polymorphism, especially TT genotype, plays an important role in refractory epilepsy. As genetic screening of this genotype may be useful to predict AEDs response before starting the treatment, further investigations should validate the association.

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“…1 ). Only 13 met the inclusion criteria and constituted the data set for this analysis [ 22 – 29 , 31 , 33 – 36 ] (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis

et al. 2017

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“…C3435T in exon 26 (rs1045642) is the most extensively studied ABCB1 SNP [23]. A number of studies have reported the correlations among ABCB1 rs1045642 polymorphism and AED pharmacokinetics [8,24,25], but few studies were focused on OXC. In the present study, we showed that patients with epilepsy with the CC genotype of ABCB1 rs1045642 had a higher OXC concentration in comparison with CT and TT genotypes, suggesting patients with homozygous wild-type carriers required lower OXC maintenance dose to achieve the referenced effective plasma level.…”

Section: Discussionmentioning

confidence: 99%

Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy

Shen

Zhang

Liu

et al. 2017

Seizure

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“…In fact, two meta-analyses of these studies revealed no significant association between resistance to AEDs and the C3435T genotype [33,35] . Most recent studies continue to provide evidence of significant associations between drug resistance and ABCB1 3435 genotypes [36] . In addition, the results of a recent meta-analysis indicates that ABCB1 C3435T polymorphism, especially TT genotype, plays an important role in refractory epilepsy; the authors suggest that genetic screening of this genotype, before starting the treatment, may be useful to predict AED response [37] .…”

Section: Pharmacoresistancementioning

confidence: 99%

Personalized medicine in epilepsy patients

Orsini¹,

Esposito²,

Perna³

et al. 2018

JTGG

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The large number of different syndromes and seizure types together with an interindividual variable response to antiepileptic drugs (AEDs) make the treatment of epilepsy challenging. Fortunately, the last few years have been characterized by a huge interest in epilepsy genetics and two methods, genome-wide analyses and next-generation sequencing, have definitely given the possibility to write a new chapter in the book of treatment of epilepsy, the chapter on precision medicine. Epilepsy offers a good opportunity for the personalization of therapy if we consider that at least one third of epileptic patients do not achieve complete seizure control with the currently available pharmacological treatments, treatment is still often empirical and precise therapy, based on the pathogenesis and the mechanism of each AED is not generally possible because this mechanism often remains incompletely known. In addition, new drugs are often not targeted but developed using in vivo seizure models, to be potentially used by the largest number of patients. This method leads to a therapy aimed at treating the symptoms and the seizures rather than the single pathogenic mechanism of each seizure type or syndrome. In this narrative review, we summarize the established evidence regarding pharmacogenomics in epilepsy and discuss the basis of precision medicine.

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Association ofABCB1C3435T polymorphism with phenobarbital resistance in Thai patients with epilepsy

Abstract: Thai patients of ABCB1 3435CC genotype and with focal epilepsy were more often PB resistant. Those two factors partly account for the variability in Thai epilepsy patients' response to phenobarbital.

Cited by 23 publications

References 39 publications

Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis

Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis

Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy

Personalized medicine in epilepsy patients

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