Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder

Hernández-Rubio, Anna; Sanvisens, Arantza; Bolao, Ferrán; Pérez‐Mañá, Clara; García-Marchena, Nuria; Fernández-Prendes, Carla; Muñoz, Álvaro; Muga, Roberto

doi:10.1038/s41598-020-77013-1

Cited by 11 publications

(8 citation statements)

References 46 publications

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“…Therefore, secondary hyperuricemia can be induced by an excessive intake of purine-rich food (e.g., red meat, offal, seafood) [21], cellular degradation processes, and high cell turnover in the context of leukemia/lymphoma [22] or anticancer treatment with chemo-or radiation therapy [23], which all increase the availability of free purines. In addition to a diet high in purines, other lifestyle-related behaviors such as excessive intake of fructose [24,25] and alcohol abuse [26,27] can also trigger hyperuricemia, which explains the high prevalence in industrialized countries and the increasing prevalence in developing countries [28]. Aside from the aforementioned environmental factors, also genetic defects in enzymes responsible for the biotransformation of purine bases can favor primary hyperuricemia, as is the case in Lesch-Nyhan or Kelley-Seegmiller syndromes [29].…”

Section: Gout and Hyperuricemiamentioning

confidence: 99%

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

Eckenstaler

Benndorf

2021

IJMS

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Urate homeostasis in humans is a complex and highly heritable process that involves i.e., metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate excretion. Importantly, disturbances in urate excretion are a common cause of hyperuricemia and gout. The majority of urate is eliminated by glomerular filtration in the kidney followed by an, as yet, not fully elucidated interplay of multiple transporters involved in the reabsorption or excretion of urate in the succeeding segments of the nephron. In this context, genome-wide association studies and subsequent functional analyses have identified the ATP-binding cassette (ABC) transporter ABCG2 as an important urate transporter and have highlighted the role of single nucleotide polymorphisms (SNPs) in the pathogenesis of reduced cellular urate efflux, hyperuricemia, and early-onset gout. Recent publications also suggest that ABCG2 is particularly involved in intestinal urate elimination and thus may represent an interesting new target for pharmacotherapeutic intervention in hyperuricemia and gout. In this review, we specifically address the involvement of ABCG2 in renal and extrarenal urate elimination. In addition, we will shed light on newly identified polymorphisms in ABCG2 associated with early-onset gout.

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Section: Gout and Hyperuricemiamentioning

confidence: 99%

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

Eckenstaler

Benndorf

2021

IJMS

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“…Hyperuricemia has been associated with MetS and coronary artery disease regardless of alcohol consumption 37 , 38 . As for the association between SUA and MetS, a recent study by our group described a close relationship between hyperuricemia and serum GGT in AUD patients 15 . Furthermore, individuals with elevated SUA levels are at risk of developing chronic renal dysfunction according to a systematic review including 13 studies and 190.000 participants 39 .…”

Section: Discussionmentioning

confidence: 97%

“…Five percent of the population aged 15 to 64 years presented a pattern of at-risk alcohol consumption in Spain and alcohol was responsible for 35% of treatment admissions in addiction units 12 . Furthermore, one in five people with alcohol use disorder (AUD) have MetS and studies have identified geographic differences in relation with life styles and environmental factors 13 due to arterial hypertension and dyslipidemia, among other mechanisms 14 , 15 . Moreover, unhealthy lifestyles (i.e., sedentarism, tobacco smoking) may be relatively frequent in individuals with alcohol misuse.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associations of metabolic syndrome in patients with alcohol use disorder

Hernández-Rubio

Sanvisens

Bolao

et al. 2022

Sci Rep

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Excessive alcohol consumption has been associated with different components of the metabolic syndrome (MetS) such as arterial hypertension, dyslipidemia, type 2 diabetes or obesity. We aimed to analyze the prevalence and associations of MetS in patients with Alcohol Use Disorder (AUD). Cross-sectional study in heavy drinkers admitted for the treatment of AUD between 2013 and 2017. Medical comorbidity, anthropometric data, alcohol use and biological parameters were obtained. MetS was established according to the harmonized definition. A total of 728 patients (22% women) were included; median age was 47 years (IQR: 40–53.5), median alcohol consumption was 160 g/day (IQR: 115–240) and prevalence of MetS was 13.9%. The multivariate analysis showed a significant dose–response effect of estimated glomerular filtration (eGFR) and MetS: relative to patients with eGFR > 90 mL/min, those with eGFR (60–90 mL/min) and those with eGFR < 60 mL/min were 1.93 times (95% CI 1.18–3.15) and 5.61 times (95% CI 1.66–19.0) more likely to have MetS, respectively. MetS was significantly associated with hyperuricemia (OR 2.28, 95% CI 1.36–3.82) and elevated serum GGT (OR 3.67, 95% CI 1.80–7.46). Furthermore, for every increase of 1 year in age, the probability of MetS increased significantly (OR 1.03, 95% CI 1.01–1.05). MetS in heavy drinkers is independently associated with reduced kidney function and metabolic risk factors including hyperuricemia and elevated serum GGT.

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“…Hyperuricemia has been associated with MetS and coronary artery disease regardless of alcohol consumption (34,35). As for the association between SUA and MetS, a recent study by our group described a close relationship between hyperuricemia and serum GGT in AUD patients (14). Furthermore, individuals with elevated SUA levels are at risk of developing chronic renal dysfunction according to a systematic review including 13 studies and 190.000 participants (36).…”

Section: Discussionmentioning

confidence: 99%

“…Excessive alcohol consumption has been associated with each of the components of MetS; speci cally, alcohol abuse is associated with a higher risk of CVD due to arterial hypertension and dyslipidemia, among other mechanisms (13,14). Moreover, unhealthy lifestyles (i.e., sedentarism, tobacco smoking) may be relatively frequent in individuals with alcohol misuse.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and impact of metabolic syndrome in patients with alcohol use disorder

Hernández-Rubio¹,

Sanvisens²,

Bolao³

et al. 2021

Preprint

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Background the metabolic syndrome (MetS) is an inflammatory disorder predisposes to type 2 diabetes and cardiovascular disease (CVD). We aimed to analyze the prevalence and associations of MetS in patients with alcohol use disorder. Methods cross-sectional study in heavy drinkers admitted for treatment of alcohol use disorder between 2013 and 2017. Medical comorbidity, anthropometric data, alcohol use and biological parameters were obtained at admission. MetS was established according to the harmonized definition of 2009. Logistic regression models were used to analyze associations of MetS. Results 728 patients (22% women) were included; median age was 47 years (IQR:40-53.5) and median alcohol consumption was 160 g/day (IQR:115–240). Overall, 9.2%, 26.7%, and 6.8% of the patients had type 2 diabetes, hypertension, and CVD, respectively. BMI was 25.0 kg/m2 (IQR:22.1–28.7) and prevalence of MetS was 13.9%. The multivariate analysis showed a significant dose-response effect of estimated glomerular filtration (eGFR) and MetS: relative to patients with eGFR > 90 mL/min, those with eGFR (60–90 mL/min) and those with eGFR < 60 mL/min were 1.93 times (95% CI: 1.18–3.15) and 5.61 times (95% CI: 1.66-19.0) more likely to have MetS, respectively. In addition, MetS was significantly associated with hyperuricemia (OR = 2.28, 95% CI: 1.36–3.82) and elevated serum GGT (OR = 3.67, 95% CI: 1.80–7.46). Furthermore, for every increase of 1 year in age, the probability of MetS increased significantly (OR = 1.03, 95% CI: 1.01–1.05). Conclusions MetS in heavy drinkers is independently associated with reduced kidney function and metabolic risk factors including hyperuricemia and elevated serum GGT.

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Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder

Cited by 11 publications

References 46 publications

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

Prevalence and associations of metabolic syndrome in patients with alcohol use disorder

Prevalence and impact of metabolic syndrome in patients with alcohol use disorder

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