Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring

Maher, Gillian M.; O’Keeffe, Gerard W.; Kearney, Patricia M.; Kenny, Louise C.; Dinan, Timothy G.; Mattsson, Molly; Khashan, Ali S.

doi:10.1001/jamapsychiatry.2018.0854

Cited by 178 publications

(126 citation statements)

References 107 publications

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“…[Mandl, Tronick, Brennan, Alpert, & Homer, 1999]. On the other hand, chronic maternal noncommunicable diseases (NCDs) such as diabetes or hypertension during pregnancy have been associated with having ASD in the offspring [Maher et al, 2018;Xu, Jing, Bowers, Liu, & Bao, 2014].…”

Section: Factors Contributing To Depression Among Mothers Of Childrenmentioning

confidence: 99%

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Naheed

Islam

Hossain³

et al. 2019

Autism Research

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This cross‐sectional study examined the burden of depression and quality of life (QoL) among mothers of children with autism spectrum disorder (ASD) attending six schools offering special educational services for children with ASD in urban Dhaka, Bangladesh. All consenting mothers were 18 years of age and older and met criteria for major depressive disorder (MDD) on the Structured Interview for DSM‐V‐TR Research Version‐non patient edition administered by trained raters. QoL was assessed by the EuroQol five‐dimensional standardized questionnaire. MDD was diagnosed in 45% of mothers and was proportionally higher among those who did not work outside the home, had no childcare support at home, expressed low level of satisfaction with the quality of providers when they had sought care for their children with ASD, and reported being recipient of negative attitudes from neighbors toward their children with ASD. QoL was negatively associated with MDD, mothers' illness, and low satisfaction with the health care providers for children with ASD, as well as experiencing a negative attitude by neighbors toward their children. QoL was positively associated with the reported family monthly income and improvement of the children with ASD on school attendance. The prevalence of MDD among mothers of children with ASD was high and associated with poor QoL. Integrating mental health services and supports for mothers in the ASD care of children is likely to address the high burden of depression they face, and improve their overall quality of life. Autism Res 2020, 13: 284–297. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The levels of depression were assessed among mothers of children with autism spectrum disorder (ASD) attending six schools offering special educational services for children with ASD in urban Dhaka, Bangladesh. Almost one in two mothers was found to have major depression. The quality of life of these mothers was generally poor. Integrating mental health services for mothers with ASD care in children is likely to address the burden of depression among the mothers of children with ASD and improve overall quality of life.

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Section: Factors Contributing To Depression Among Mothers Of Childrenmentioning

confidence: 99%

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Naheed

Islam

Hossain³

et al. 2019

Autism Research

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“…Preeclampsia (PE) is a pregnancy-induced hypertensive disorder marked by a new-onset hypertension and one or more maternal manifestations including proteinuria, maternal organ dysfunction, or uteroplacental dysfunction presenting after 20 gestational weeks [8]. This condition is the second main cause of maternal death worldwide and one of the leading causes of adverse fetal outcomes, such as low birth weight and prematurity [9][10][11][12]. The widely used clinical subclassification for assessing the severity of preeclampsia includes early-and late-onset PE: diagnosed at their occurrence before and after 34 weeks of gestation, respectively [8].…”

Section: Introductionmentioning

confidence: 99%

Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden

Mandakh

Rittner

Flanagan

et al. 2020

IJERPH

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The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM 2.5 and PM 10 ), and NO X at the maternal residential address estimated by Gaussian dispersion modeling from 2000 to 2009. Analyses were conducted using binary logistic regression. A subtype analysis for small-for-gestational age (SGA) was performed. All analyses were adjusted for obstetrical risk factors and socioeconomic predictors. There were 1286 (2.9%) PE cases in the analysis. An adjusted odds ratio (AOR) of 1.35 with a 95% confidence interval (CI) of 1.11-1.63 was found when comparing the lowest quartile of BC exposure to the highest quartile in the third trimester The AOR for PE associated with each 5 µg/m 3 increase in locally emitted PM 2.5 was 2.74 (95% CI: 1.68, 4.47) in the entire pregnancy. Similar patterns were observed for each 5 µg/m 3 increment in locally emitted PM 10 . In pregnancies complicated by PE with SGA, the corresponding AOR for linear increases in BC was 3.48 (95% CI: 1.67, 7.27). In this low-level setting, maternal exposure to ambient air pollution during gestation was associated with the risk of developing PE. The associations seemed more pronounced in pregnancies with SGA complications, a finding that should be investigated further.

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“…All these ADHD outcomes are also risk factors for CAD (34) and hence may act additively as mediators of the observed effect of genetic liability for ADHD on CAD. There are some reports of observational associations between ADHD and cardio-vascular diseases (41, 42), although such studies are difficult to conduct due to the latency between exposure and outcome. Here we report evidence supporting a causal effect of genetic liability for ADHD on CAD but not on other cardiovascular risks (such as hypertension).…”

Section: Discussionmentioning

confidence: 99%

ADHD genetic liability and physical health outcomes - A two-sample Mendelian randomization study

Leppert

Riglin

Dardani

et al. 2019

Preprint

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Objective: Attention-deficit/hyperactivity disorder (ADHD) has been associated with a broad range of physical health problems, including cardiometabolic, neurological and immunological conditions. Determining whether ADHD plays a causal role in these associations is of great importance for treatment and prevention but also because comorbid health problems further increase the serious social and economic impacts of ADHD on individuals and their families. Methods:We used a two-sample Mendelian randomization (MR) approach to examine the causal relationships between genetic liability for ADHD and previously implicated physical health conditions. 11 genetic variants associated with ADHD were obtained from the latest summary statistics. Consistent effects obtained from IVW, weighted median and MR Egger methods were taken forward for sensitivity analysis, including bidirectional MR and multivariable MR (MVMR). Results:We found evidence of a causal effect of genetic liability for ADHD on childhood obesity (OR:1.29 (95% CI:1.02,1.63)) and coronary artery disease (CAD) (OR:1.11 (95% CI:1.03,1.19)) with consistent results across different MR approaches. There was further evidence for a bidirectional relationship between genetic liability for ADHD and childhood obesity. The effect of genetic liability for ADHD on CAD was independent of smoking heaviness but was attenuated when simultaneously controlling for childhood obesity. There was little evidence for a causal effect on other cardiometabolic, immunological, neurological disorders and lung cancer. Conclusion:Our findings strengthen the argument for early treatment and support for children with ADHD and their families and especially promoting physical activity and providing them with dietary advice to reduce future risk for developing CAD.3 Key Message• Epidemiological studies have reported observational associations between ADHD and adult onset physical health outcomes.• Mendelian Randomization can be used to assess causal associations for ADHD on health outcomes that would traditionally require long term follow-up and may suffer confounding • We found that genetic liability for ADHD was associated with coronary artery disease and there was evidence for a bidirectional association between genetic liability for ADHD and childhood obesity• Multivariable mendelian randomization suggests that the link between genetic liability and coronary artery disease might partially act through childhood obesity but was independent of smoking heaviness• There was little evidence of a causal of ADHD on other cardiometabolic and immunological diseases.

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Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring

Abstract: Exposure to HDP may be associated with an increase in the risk of ASD and ADHD. These findings highlight the need for greater pediatric surveillance of infants exposed to HDP to allow early intervention that may improve neurodevelopmental outcome.

Cited by 178 publications

References 107 publications

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Burden of major depressive disorder and quality of life among mothers of children with autism spectrum disorder in urban bangladesh

Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden

ADHD genetic liability and physical health outcomes - A two-sample Mendelian randomization study

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