Association of hyperglycemia and markers of hepatic dysfunction with dextrose infusion rates in Korean patients receiving total parenteral nutrition

Hypoglycemia During the Temporary Interruption of Parenteral Nutrition Infusion in Pediatric Hematopoietic Stem Cell Transplantation

“…Therefore, we emphasize that all children with higher GIR may develop hypoglycemia because of temporary PN infusion interruption. In adults, GIR >4–5 mg/kg/min during PN infusion was reported with more frequent complications, such as hyperglycemia and abnormal liver function test 10 , 11 . Although much higher GIR levels during PN infusion are usually allowed in children, 12 GIR >5 mg/kg/min in children might be another risk factor for complications associated with even temporary PN infusion interruption.…”

Complications and Monitoring – Guidelines on Parenteral Nutrition, Chapter 11

“…Hyperglycaemia is detected in up to 50% of intensive care patients who are not receiving PN, and the rate increases with added PN [35]. A study in surgical intensive care patients showed benefits of tight blood glucose control (glucose 80–110 mg/dL) with regards to mortality and morbidity when compared to conventional blood sugar control (glucose 80–200 mg/dL) [32].…”

Hyperglycemia and Nutrition Support: Theory and Practice

“…Other authors have also suggested limiting maximal PN dextrose infusion rates to 4 mg/kg per minute, although not all studies have shown higher rates of hyperglycemia or transaminitis at higher rates. 60 Consideration has been given to avoiding hyperglycemia by use of alternative carbohydrate sources such as sodium lactate. 61 Unfortunately, this cannot be recommended because worrying increases in arterial pH resulted from bicarbonate generation.…”