Association of hyaluronic acid with a collagen scaffold may improve bone healing in critical-size bone defects

Abstract

Within the limits of this study, a 1% HA gel associated with a collagen scaffold can improve new bone formation in critical-size defects. However, this treatment never resulted in complete closure of the defects and healing in the major portion of the defects was characterized by fibrous tissue.

Hyaluronic Acid Improves Bone Formation in Extraction Sockets With Chronic Pathology: A Pilot Study in Dogs

“…Mendes et al 11 revealed that HA could enhance healing in tooth sockets by promoting the expression of bone morphogenetic protein‐2 and osteopontin. In addition, it was shown that HA with a collagen sponge could stimulate improvement of bone formation in bone defects 20 . In addition, in a recent systematic review, HA application as an adjunct to periodontal treatment was suggested to be beneficial 25 …”

“…A minimum sample size of four dogs per group was calculated by the following power analysis. Effect size for the amount of mineralized bone was determined as 0.9171 based on the reported difference of bone formation by HA using an animal model, 20 and the α and β error levels were fixed at 0.05 and 0.2, respectively. Accordingly, six sockets were allocated to each group to allow a non‐parametric statistical test to be performed.…”

Effect of hyaluronic acid in bone formation and its applications in dentistry

“…HA has been used in combination with filler materials, mostly in particulate form, to stimulate bone formation . The mechanical properties of HA can be improved by the incorporation of these filler materials.…”

Intérêt des éponges de collagène pour prévenir la résorption osseuse alvéolaire post-extractionnelle : revue systématique de la littérature

“…Dans un cas, il s'agissait de défauts osseux au niveau de la crête iliaque [20]. Dans deux cas, il s'agissait de défaut osseux de calvaria [29,30] et dans un autre cas il s'agissait d'une perforation de l'os du fémur [31].…”

“…Dans les études sélectionnées, la néoformation osseuse après comblement avec une éponge de collagène a été comparée avec des défauts laissés vides [20,[29][30][31], d'autres agents hémostatiques [20], du ßTCP, du BioOss Collagen® [29] ou encore un gel d'acide hyaluronique [30].…”