Association of human papillomavirus infection and vulvar intraepithelial neoplasia: A morphological and immunohistochemical study of 30 cases

Rueda-Leverone, Nidia Gómez; Paola, Guillermo R. di; Meiss, Roberto P.; Vighi, Susana; Llamosas, Fernando

doi:10.1016/0090-8258(87)90025-4

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…And, evidence of exposure to many sexually transmitted organisms has been observed in women with cervical cancer, including syphilis, genital herpes, human papilloma virus, and Chlamydia (Levin et al, 1942;Rojel, 1952;Melnick et al, 1974;Kauffman & Adam, 1986;Durst et al, 1983;Syrjanen et al, 1985;Schachter et al, 1982;Cardillo, 1985). These same diseases also have been found more often in women with vulvar cancer than would be expected in a similar group of women without this disease (Franklin & Rutledge, 1974;Mabuchi et al, 1985;Schwartz & Naftolin, 1981;Rueda-Leverone et al, 1987) and have been found in patients with anal cancer more often than in controls (Gal et al, 1987;Bogomoletz et al, 1985;Daling et al, 1987).…”

Section: Discussionmentioning

confidence: 84%

“…Human papilloma virus has been found in tumour tissue from the cervix, vulva, vagina, and anus (Okagaki, 1984;Durst et al, 1983;Syrjanen et al, 1985;Rueda-Leverone et al, 1987;Gal et al, 1987;Winkler & Richart, 1987). In addition, there have been several reports of multicentric human papilloma virus infections in the same individual (Sfameni et al, 1986;Walker et al, 1983;Bergeron et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

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Multiple primary tumours in women with vulvar neoplasms: a case-control study

Sherman

Daling²,

Chu³

et al. 1988

Br J Cancer

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Summary We sought to determine whether women with in situ or invasive squamous cell vulvar cancer were more likely than other women to have had a previous or concurrent tumour at other anogenital sites. One hundred and fifty-eight women with vulvar cancer were identified who were first diagnosed during 1980-1985, were ages 18-79 years at that time, and were residents of one of three counties in western Washington. Two control groups were selected: (1) from records of hospital pathology departments, a sample of 113 women with certain benign conditions of the vulva; (2) through random digit dialing, a sample of 212 women from the general population of these counties. Information on a history of other cancers, and on sexual, reproductive, medical, and demographic characteristics was collected from cases and controls in at-home interviews. Cases were more likely to report a history of other anogenital cancers than were controls, with relative risks of 3.5-29.8, depending on the type of case group and type of control. These associations were not explained by case-control differences in demographic characteristics or frequency of cervical screening. On the other hand, prior or concurrent non-anogenital cancers were equally common in cases and controls. These results support the hypothesis that the different anogenital cancers have at least one aetiology in common.Recent research suggests that cancers of the cervix, vulva, and anus may share one or more risk factors (Peters et al., 1984;Okagaki, 1984). If this is true, women with cancer at one anogenital site would be at increased risk of developing another anogenital tumour. One way to examine this possibility is to see if women with cancer at a specific anogenital site were more likely than other women to have had a previous or concurrent tumour at another anogenital site.There have been numerous reports of women with squamous cell cancer of the vulva who have had one or more second primary malignancies of the anogenital tract (Taussig, 1940;Cromer, 1963;Day, 1958;Caberra et al., 1966), especially the cervix (Franklin & Rutledge, 1974;Friedrich et al., 1980), that were detected before (McPherson et al., 1963), simultaneous with (Eichner, 1956), or after the vulvar tumour (Diehl et al., 1951). While these reports are intriguing, they were not derived from a defined population, nor were the cases compared to a control group. Using data on cancer incidence rates from the Connecticut Tumor Registry, Schoenberg (1977) showed that women who had cervical cancer were at greater risk for other anogenital malignancies compared with other women. In a hospitalbased, case-control study of vulvar cancer, Mabuchi et al. (1985) found that six of 149 women with vulvar cancer but none of 149 controls had a history of prior urogenital cancer.As part of a case-control study of women with in situ and invasive vulvar cancer, we had the opportunity to examine the hypothesis that multiple anogenital malignancies occur more commonly that would be predicted by chance. (2) a random sampl...

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