Association of Human Papillomavirus Infection with Palmoplantar Epidermal Cysts in Korean Patients

Abstract

Human papillomavirus (HPV) infection can develop into many different kinds of diseases ranging from simple warts to carcinoma in situ. Some investigators have recently suggested that HPV infection could be closely related to palmoplantar epidermal cysts. The aim of this study was to determine the existence of HPV and its subtype in palmoplantar epidermal cysts of Korean patients. We investigated 13 cases of palmoplantar epidermal cysts by employing clinical, histopathological and immunohistochemical examinations. In addition, PCR was performed using HPV 57 and 60 type primers. Four of the 13 cases (30.8%) showed the distinct histopathological features of palmoplantar epidermal cysts such as parakeratosis, vacuolar structures and eosinophilic inclusion bodies and these 4 cases showed positive immunohistochemical staining reactions for HPV. PCR for HPV detected type 60-positive bands in 5 of the 13 cases (38.5%), which included the 4 cases that were positive for immunohistochemical staining. These results show that HPV is associated with some cases of palmoplantar epidermal cysts in Korean patients, suggesting that HPV may play a role in the pathogenesis of these cysts.

Detection of Human Papillomavirus Type 39 in a Seborrheic Inclusion Cyst of the Buttock

“…Although few data have been published in regards to SIC with HPV, ECs of cutaneous cysts have been relatively well studied in regards to HPV infection. HPV types 57 and 60 were recently implicated in palmoplantar ECs[6]. However, HPV type 39, which was detected in our case, has not been identified in EC.…”

“…Park et al . [6] described the development of EC in weight-bearing surfaces using three stages: first, a pre-existing wart is implanted into the dermis by weight; second, the implanted portion forms a cyst in the dermis. Finally, the pre-existing wart undergoes regression, leaving only the dermal cyst behind.…”

Epidermal inclusion cyst of the maxillofacial region

“…Human papillomavirus type 57 or 60 infections may be additional factors in the development of palmoplantar epidermoid cysts [9][10][11]. Oral and pharyngeal epidermoid cysts of the inclusion cyst variety also occur, but are rare in adults and are frequently so small that they are not biopsied.…”

An Unusual Case of a Recurrent Seborrheic/Epidermal Inclusion Cyst of the Maxillofacial Region

“…Sebaceous cyst is a misnomer as these cysts are not of sebaceous origin. Human papillomavirus type 57 or 60 infections may be additional factors in the development of palmoplantar epidermoid cysts [9][10][11]. Oral and pharyngeal epidermoid cysts of the inclusion cyst variety also occur, but are rare in adults and are frequently so small that they are not biopsied.…”