Association of Human Leukocyte Antigens (HLA) profile and acute lymphoblastic leukemia in Lebanese pediatric patients: A first report from Lebanon

Karaaoui, AbdulKarim El; Tamim, Hani; Achkar, Hani El; Fermanian, Puzant; Abbas, Fatmeh; Keleshian, Sose; Muwakkit, Samar; Mahfouz, Rami

doi:10.1016/j.humgen.2022.201072

Cited by 1 publication

(1 citation statement)

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“…While the precise biological mechanisms initiating ALL remain largely undefined, extensive research has illuminated the critical involvement of specific HLA alleles in the disease's onset and progression [6,13,14]. Detailed analysis of these alleles in ALL patients promises to unlock valuable insights into prognosis, therapeutic response, and the likelihood of relapse [15,16,5]. In this context, the current investigation is designed to rigorously assess the associations between HLA-A, HLA-B, and HLA-DRB1 alleles and the susceptibility to ALL within a distinct cohort of Iranian patients.…”

Section: Discussionmentioning

confidence: 99%

Human Leukocyte Antigen Alleles (HLA-A, HLA-B, and HLA-DRB1) are associated with Acute Lymphoblastic Leukemia (ALL) : A Case-Control Study in a Sample of Iranian Population

Kohansal Vajari,

Ehsan,

Ghiasi

et al. 2024

Asian Pac J Cancer Prev

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Acute lymphoblastic leukemia (ALL), the most prevalent cancer among children, sees about 75% of leukemia cases globally [1,2]. Despite high survival rates exceeding 85% for those without relapse, those experiencing relapse face severe prognoses. This positions ALL as a significant pediatric oncological challenge [3,4].Emerging studies suggest a sophisticated interplay between genetics and environmental factors in ALL's development. The timing of viral exposures and subsequent immune responses are particularly critical. This context highlights the importance of the Human Leukocyte Antigen (HLA) system in genetic susceptibility to ALL. The HLA, or major histocompatibility complex, involves over 100 polymorphic genes on chromosome 6 that are pivotal in immune defense, making it a focal point in ALL research [5,6].The HLA system, also known as the major histocompatibility complex (MHC), comprises a set of highly polymorphic genes located on chromosome 6.

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