Association of Human Leukocyte Antigen with Interstitial Lung Disease in Rheumatoid Arthritis: A Protective Role for Shared Epitope

Furukawa, Hiroshi; Oka, Shomi; Shimada, Kota; Suzuki, Shoji; Ohashi, Jun; Matsui, Toshihiro; Ikenaka, Tatsuoh; Nakayama, Hisanori; Hashimoto, Atsushi; Takaoka, Hirokazu; Arinuma, Yoshiyuki; Okazaki, Yuko; Futami, Hidekazu; Komiya, Akiko; Fukui, Naoshi; Nakamura, Tadashi; Migita, Kiyoshi; Suda, Arnold J.; Nagaoka, Shinya; Tsuchiya, Naoyuki; Tohma, Shigeto

doi:10.1371/journal.pone.0033133

Cited by 67 publications

(52 citation statements)

References 25 publications

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“…A Japanese study evaluated the association between RA-ILD and specific HLA-DRB1 subtype alleles; while some alleles appeared to have a significant association, others appeared protective, and the majority had no significant association either way. This suggests that the shared epitope may have a role in the pathogenesis of rheumatoid arthritis, but not necessarily in the development of ILD [27].…”

Section: Pathogenesismentioning

confidence: 99%

Rheumatoid arthritis-associated lung disease

et al. 2015

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Section: Pathogenesismentioning

confidence: 99%

Rheumatoid arthritis-associated lung disease

et al. 2015

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“…n RISK FACTORS (16). Demographic characteristics, such as male gender and older age at onset, have now been confirmed to be associated with ILD by several studies (9, 10, 13, 17).…”

Section: Reviewmentioning

confidence: 94%

The onset site of rheumatoid arthritis: the joints or the lung?

et al. 2016

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The etiopathogenesis of rheumatoid arthritis (RA) is not yet fully elucidated and the site of inflammation onset is still a matter of debate. The presence of autoantibodies as well as clinical manifestations, such as interstitial lung disease, before the onset of arthritis seems to be in favour of the hypothesis that initial pathogenic events take place in tissues other than the joint. In this review article we summarize the most recent literature on extra-synovial autoimmunity triggers eventually leading to RA, with particular focus on the role of the lung. To date, anti-cyclic citrullinated peptide antibodies (ACPAs) are considered central players in RA pathogenesis and represent the gold-standard for disease diagnosis. Lungs and mucosae are exposed to environmental stimuli such as dusts and smoke which have been shown to foster citrullination of peptides in lungs thereby triggering the production of ACPA. In addition, other mechanisms of disease pathogenesis independent of citrullination play an important role. Deeper knowledge of these processes could represent a huge step forward in the management of RA, with dramatic impact on diagnosis, prevention, prognostic stratification and treatment of the disease.

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“…We further estimated 80 patients would be required totally, namely 40 for each group to allow for a 20 percent loss of follow-up. n 1 =n 2 = 2×PQ×(U α +U β ) 2 /(P XFC -P TPT ) 2 Where n 1 and n 2 represent the sample size of the trial group and the control group, respectively. P XFC and P TPT were the effectiveness rates of XFC and TPT, respectively.…”

Section: Sample Size and Randomizationmentioning

confidence: 99%