Association of HSV reactivation and pro-inflammatory cytokine levels with the severity of stomatitis after BEAM chemotherapy and autologous SCT

Rüping, Maria J. G. T.; Keulertz, Constance; Vehreschild, Jörg J.; Lövenich, Harry; Söhngen, D; Wieland, Ulrike; Cornely, Oliver A.

doi:10.1007/s00520-010-0940-8

Cited by 13 publications

(11 citation statements)

References 28 publications

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“…Our findings support the use of antiviral prophylaxis in HSV-seropositive HSCT recipients. 27 A previous study found an association between HSV-1 and stomatitis in autologous HSCT recipients as well, 28 whereas another study failed to establish a relationship between the presence of HSV-1 and mucositis in HSCT recipients. 4 The use of antiviral prophylaxis probably limited the role of HSV in this latter study.…”

Section: Discussionmentioning

confidence: 99%

Viral loads and antiviral resistance of herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients

Beek

Laheij

Raber-Durlacher

et al. 2012

Bone Marrow Transplant

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Ulcerative oral mucositis and infection are frequent complications in hematopoietic stem cell transplant (HSCT) recipients. The aim of this study was to investigate the relationship between oral ulcerations and HSV-1, EBV and CMV excretion and the presence of aciclovir-resistant HSV-1 strains in HSCT recipients. This prospective observational study included 49 adult patients who underwent allogeneic HSCT. In total, 26 patients received myeloablative and 23 received non-myeloablative conditioning. Ulcerations on non-keratinized and keratinized oral mucosa were scored and oral rinsing samples were taken twice weekly. Viral loads were determined by real-time PCR. Samples from patients remaining HSV-1 positive despite antiviral treatment were studied for resistance to antivirals. Having an HSV-1 or EBV DNA --positive sample was a significant predictor for ulceration of keratinized mucosa. HSV-1 was a significant predictor for ulcerations on non-keratinized mucosa as well. Persistent HSV-1 infection occurred in 12 of 28 patients treated with antiviral medication and aciclovir-resistant HSV-1 was found in 5 persistent infections. In conclusion, HSV-1 is a predictor of ulcerations on non-keratinized as well as keratinized oral mucosa following HSCT. The role of EBV deserves further study. Persistent HSV-1 replication despite antiviral treatment is common and is due to resistance in 18% of treated patients.

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Section: Discussionmentioning

confidence: 99%

Viral loads and antiviral resistance of herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients

Beek

Laheij

Raber-Durlacher

et al. 2012

Bone Marrow Transplant

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“…Overall, a trend toward increasing levels of proinflammatory cytokines, such as as TNF-a and IL-1, in the first days after autologous and allogeneic HSCT, although some contradictory results in salivary TNF-a levels in UWS and SWS have been reported [15,38,39] (Figure 3; Supplementary Table S3). Little is known about changes in the anti-inflammatory cytokines; only 1 study found increased levels of IL-10 in UWS and SWS of adult allogeneic HSCT recipients at days +7 and +14 [15].…”

Section: Saliva Compositionmentioning

confidence: 99%

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Leeuwen

Potting

Huysmans

et al. 2019

Biology of Blood and Marrow Transplantation

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A B S T R A C T Severe oral problems, including oral mucositis (OM) and xerostomia, often occur after conditioning therapy for hematopoietic stem cell transplantation (HSCT). Saliva plays a major role in protecting the oral mucosa and teeth. Alterations in salivary flow rate or salivary components resulting in decreased salivary defence mechanisms may affect oral/mucosal health and may influence the severity of OM. A systematic review was conducted to assess the current scientific knowledge on changes in salivary function and composition before and after HSCT. All English or Dutch articles examining salivary flow rate or salivary components before and after HSCT were included after title/abstract selection by 2 independent reviewers (weighted k = .91). After quality assessment and exclusion of all research groups with both children age <14 years and adults, 33 articles were included for data analysis. Overall, the salivary flow rate was decreased at several days and months after HSCT. Although several salivary components were studied, most components were examined in only 1 or 2 studies with different patient populations or at different time points after HSCT. At 7 days after HSCT, albumin and proinflammatory cytokines were increased, whereas secretory IgA and components of the salivary antioxidant system were decreased. Secretory IgA levels were still reduced at 1 month after HSCT but returned to pre-HSCT values at 6 months after HSCT. Lactoferrin, secretory leukocyte protease inhibitor, and b 2 -microglobulin levels were increased at 6 months after HSCT. Our findings show that changes in saliva reflect an inflammatory response occurring immediately after HSCT, followed by evidence of increased salivary antimicrobial defense mechanisms by 6 months after HSCT.

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“…Rüping et al [172] studied the association of IL-1 and TNF- α in oral saliva and viral pathogens with the severity of ulcerations in autologous HSCT. An association of the severity of oral ulceration and HSV reactivation was demonstrated.…”

Section: Infectionsmentioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.

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Association of HSV reactivation and pro-inflammatory cytokine levels with the severity of stomatitis after BEAM chemotherapy and autologous SCT

Cited by 13 publications

References 28 publications

Viral loads and antiviral resistance of herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients

Viral loads and antiviral resistance of herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients

Salivary Changes before and after Hematopoietic Stem Cell Transplantation: A Systematic Review

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

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