Association of HPV infections with second primary tumors in early‐staged oral cavity cancer

Huang, Shiang‐Fu; Li, H F; Liao, Chun‐Ta; Wang, H M; Chen, I H; Chang, Joseph Tung-Chieh; Chen, Y J; Cheng, Ann‐Joy

doi:10.1111/j.1601-0825.2012.01950.x

Cited by 26 publications

(25 citation statements)

References 40 publications

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“…In this study, we found only four poorly differentiated tumors; one of them overexpressed p16 INK4a protein, and only one case with basaloid appearance. Patients with tumors of the oral cavity have been found to have a high incidence of second primary tumors in the oral cavity, with an incidence ranging from 15 to 37 % [11]. In this study, 13 cases of 125 (10 %) developed a second primary tumor, and this was not significantly associated to p16 INK4a overexpression.…”

Section: Discussionmentioning

confidence: 49%

“…In patients with OPSCC, HPV infection was found to be associated with favorable prognosis [11]. However, the role of HPV infection on the survival of OSCC patients remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…Among the HNSCC, in particular, oropharyngeal cancer is known to be strongly associated with HPV infection, but the role of HPV in other anatomical sites of the upper aerodigestive tract, such as the oral cavity, remains unclear. Up to 81 % of high-risk HPV, genotypes have been detected in normal oral mucosa [9], and Syrjänen [10], in 1983, showed the HPV involvement in OSCC, mainly HPV-16 [11]. The disparity of results published so far, in terms of HPV infection rates ranges from 0 to 100 % [12].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

Rodríguez-Santamarta

Rodrigo

García-Pedrero

et al. 2016

Eur Arch Otorhinolaryngol

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The aim of this study was to analyze the prevalence of high-risk HPV in oral squamous cell carcinoma (OSCC) in a northern Spanish population, as well as to ascertain the prognostic role of p16 expression. The examination samples were collected from paraffin tissue blocks, from 125 patients surgically treated between 1996 and 2007. All cases were histologically evaluated, and the presence of HPV was assessed by p16 and p53immunohistochemistry followed by DNA detection by in situ hybridization (ISH) and polymerase chain reaction (PCR) amplification using the combination of consensus primers MY11/GP6 + . Fourteen cases (11 %) were p16-immunopositive, and p53 was scored positive in 73 cases (58 %). Five cases (4 %) showed a simultaneous p16-positive and p53-negative immunostaining. ISH was negative in all the cases. Among the p16INK4a-immunopositive cases, PCR amplification failed to reveal HPV DNA in any tumor samples. There were no statistically significant differences in any clinical or pathological characteristics of the patients regarding p16 expression. T classification, neck-node metastasis, and clinical stage showed outcome relevance. However, no significant differences in cause-specific survival based on p16INK4a were observed. We did not find any high-risk HPV types in our patients, thus, are unlikely that HPV has an important role in the etiology of OSCC. p16INK4a protein was neither an accurate marker of HPV infection nor a prognosis marker in OSCC.

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Section: Discussionmentioning

confidence: 49%

“…In patients with OPSCC, HPV infection was found to be associated with favorable prognosis [11]. However, the role of HPV infection on the survival of OSCC patients remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

Rodríguez-Santamarta

Rodrigo

García-Pedrero

et al. 2016

Eur Arch Otorhinolaryngol

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“…15 A recent study suggested that the infection of HPV in early-stage oral SCC enhances the susceptibility of developing secondary malignancy, especially HPV-18. 17 However, other authors reported a lower risk of SPT in HPV-positive oropharyngeal SCC, emphasizing that this fact may be a major contributor to the demonstrated superior survival outcomes among patients with HPV-positive disease. 18 The presence of HPV was detected in the esophageal mucosa of our patient, but the oral lesion was HPV-negative.…”

Section: Discussionmentioning

confidence: 96%

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

Lopes

Aquino

Morais

et al. 2015

The Journal of Contemporary Dental Practice

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Aim: This manuscript aims to describe an unusual case of multiple second primary squamous cell carcinomas (SCCs) in several sites of the oral mucosa in a nonsmoker and nondrinker woman and to discuss the diagnostic criteria, clinicopathological aspects and outcome of second primary tumor (SPT). Background:Patients treated for SCC of the head and neck are at high risk for developing SPT arising from the same dysplastic mucosal field. Currently, there is no reliable method to predict which of the patients will develop SPT. Case description:A 64-year-old nonsmoker and nondrinker woman developed several second primary oral SCCs in 7 years of follow-up, most of them being synchronic, treated by surgery without and with chemotherapy and radiotherapy. Conclusion:Patients treated for SCC require a long-term and careful follow-up as the development of SPT contributes with significantly negative impact on the prognosis.Clinical significance: This report describes the diagnosis and management of a very unusual case of several SPTs affecting different sites of the oral mucosa in the same patient. Moreover, the patient had no apparent risk factors associated

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“…Some viruses are capable of setting on oncogenesis (HPV) on their own, while others (EBV, CMV, HSV) simply accelerate an already triggered process. Besides, different genotypes of the same virus can be highly oncogenetic (HPV-16, 18), while others are characterised with low or suspected oncogenetic potential (HPV-6, 11) (1,30,35,37,38).…”

Section: Hpv Ebv Hsv and Oral And Oropharyngeal Cancersmentioning

confidence: 99%

Human Papillomaviruses, Herpes Viruses and Oral Neoplasms

Krasteva¹,

Dobreva²,

Galabov³

et al. 2015

MedInform

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Human papillomaviruses constitute the most widely spread sexually transmitted viral infection world-wide. In about 1% of the cases, a continuing HPV infection can lead to the appearance of precancerous conditions. In a subsequent carcinoma progression, different types of cancer can develop -cervical, rectal, penile, oral, throat, laryngeal, etc. More than 200 HPV types have been established, with at least 25 found in lesions in the oral cavity.The attention of specialists in the field has been focused on the association between HPVs and oral carcinogenesis. It is highly recommended that each patient with a suspected lesion in the oral cavity should be tested for HPV.

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Association of HPV infections with second primary tumors in early‐staged oral cavity cancer

Abstract: There are 30% of the patients with OSCC infected with HPV, with most high-risk types. HPV-18 infection may enhance the susceptibility of second primary tumors. Large scale of validation study will be needed to confirm this result.

Cited by 26 publications

References 40 publications

Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

Multiple Second Primary Oral Squamous Cell Carcinomas in a Nonsmoker and Nondrinker Woman: Case Report and Review of the Literature

Human Papillomaviruses, Herpes Viruses and Oral Neoplasms

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