Association of HLA-G 3′UTR polymorphisms with response to malaria infection: A first insight

Garcia, André; Milet, Jacqueline; Courtin, David; Sabbagh, Audrey; Massaro, Juliana Doblas; Castelli, Erick C.; Migot-Nabias, Florence; Favier, Benoît; Rouas‐Freiss, Nathalie; Donadi, Eduardo Antônio; Moreau, Philippe

doi:10.1016/j.meegid.2013.02.021

Cited by 37 publications

(33 citation statements)

References 45 publications

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“…For instance, according to our results, UTR-5 and UTR-7 frequencies are higher in recurrent pregnancy loss [50], whereas UTR-1 has been associated with reduced risk of recurrent pregnancy loss [51]. Besides, 3’UTR variants have been identified as potential prognostic biomarkers to determine susceptibility to infections [52, 53],the success of transplantation [54], and the outcome of cancer [55] and autoimmune diseases [56]. Even if we cannot neglect the influence of the HLA-G 5’URR haplotypes that are in linkage disequilibrium with 3’UTR [18], here we demonstrated that 3’UTR variants are directly involved in the differential response to cellular endogenous factors and are therefore potential target sites to consider for the design of novel therapeutic approaches.…”

Section: Discussionmentioning

confidence: 97%

Haplotypes of the HLA-G 3’ Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially

et al. 2017

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The immune checkpoint HLA-G prevents maternal rejection of the fetus and contributes in cancer invasion and acceptance of allografts. The 5’ and 3’ regulatory regions of the HLA-G gene are polymorphic and balancing selection probably maintains this variability. It is proposed that nucleotide variations may affect the level of HLA-G expression. To investigate this issue we aimed to analyze how haplotypes of the 3’ untranslated region (3’UTR) with highest worldwide frequencies, namely UTR-1, UTR-2, UTR-3, UTR-4, UTR-5, UTR-18 and UTR-7, impact the expression of a luciferase reporter gene in vitro. Experiments performed with the HLA-G positive cell lines JEG-3 (choricarcinoma) and FON (melanoma), and with the HLA-G negative cell lines M8 (melanoma) and U251MG (glioblastoma) showed that the HLA-G 3’UTR polymorphism influences the response to endogenous cellular factors and may vary according to the cell type. UTR-5 and UTR-7 impact the activity of luciferase the most whereas UTR-2, UTR-3, UTR-4, and UTR-18 have intermediate impact, and UTR-1 has the lowest impact. These results corroborate the previous associations between amounts of plasma sHLA-G levels and 3’UTR haplotypes in healthy individuals and reinforce that 3’UTR typing may be a predictor of the genetic predisposition of an individual to express different levels of HLA-G.

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Section: Discussionmentioning

confidence: 97%

Haplotypes of the HLA-G 3’ Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially

et al. 2017

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“…A possible explanation for different immune tolerance effects of PAM relates to HLA-G polymorphisms and their association with different malaria susceptibility [38]. HIV infection influences as well a woman’s susceptibility to malaria, and this is of major concern as both diseases overlap considerably in sub-Saharan Africa.…”

Section: Methods: Search Strategy and Selection Criteriamentioning

confidence: 99%

Pregnancy-associated malaria and malaria in infants: an old problem with present consequences

Moya-Alvarez

Abellana

Cot

2014

Malar J

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Albeit pregnancy-associated malaria (PAM) poses a potential risk for over 125 million women each year, an accurate review assessing the impact on malaria in infants has yet to be conducted. In addition to an effect on low birth weight (LBW) and prematurity, PAM determines foetal exposure to Plasmodium falciparum in utero and is correlated to congenital malaria and early development of clinical episodes during infancy. This interaction plausibly results from an ongoing immune tolerance process to antigens in utero, however, a complete explanation of this immune process remains a question for further research, as does the precise role of protective maternal antibodies. Preventive interventions against PAM modify foetal exposure to P. falciparum in utero, and have thus an effect on perinatal malaria outcomes. Effective intermittent preventive treatment in pregnancy (IPTp) diminishes placental malaria (PM) and its subsequent malaria-associated morbidity. However, emerging resistance to sulphadoxine-pyrimethamine (SP) is currently hindering the efficacy of IPTp regimes and the efficacy of alternative strategies, such as intermittent screening and treatment (IST), has not been accurately evaluated in different transmission settings. Due to the increased risk of clinical malaria for offspring of malaria infected mothers, PAM preventive interventions should ideally start during the preconceptual period. Innovative research examining the effect of PAM on the neurocognitive development of the infant, as well as examining the potential influence of HLA-G polymorphisms on malaria symptoms, is urged to contribute to a better understanding of PAM and infant health.

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“…An association of HLA-G 3′UTR polymorphisms with the antibody response to Plasmodium falciparum has also recently been reported [49, 83]. …”

Section: Mechanisms Of Hla-g Modulation During Infectionmentioning

confidence: 99%

Immunomodulatory Properties of HLA-G in Infectious Diseases

Amiot

Samson

2014

Journal of Immunology Research

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HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions. The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. The relevance of studies on HLA-G expression lies in the well known inhibitory effect of this molecule on all cell types involved in innate and adaptive immunity, favoring escape from immune control. In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent. The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections. We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G. New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases.

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Association of HLA-G 3′UTR polymorphisms with response to malaria infection: A first insight

Cited by 37 publications

References 45 publications

Haplotypes of the HLA-G 3’ Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially

Haplotypes of the HLA-G 3’ Untranslated Region Respond to Endogenous Factors of HLA-G+ and HLA-G- Cell Lines Differentially

Pregnancy-associated malaria and malaria in infants: an old problem with present consequences

Immunomodulatory Properties of HLA-G in Infectious Diseases

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