Association of HLA-DR-DQ polymorphisms with diabetes in Tunisian patients

Mrissa, Najiba Fekih; Mrad, Meriem; Ouertani, H.; Baatour, Makrem; Sayeh, Aicha; Nsiri, Brahim; Lamine, Khaled; Zidi, B.; Gritli, Nasreddine

doi:10.1016/j.transci.2013.01.012

Cited by 22 publications

(12 citation statements)

References 30 publications

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“…In the present study, analysis of HLA class II alleles and haplotypes frequency in a sample of Iranian population not only confirms previous reports from the country (Sayad et al ., ; Rabbani et al ., ) but also is in line with several results observed in other Caucasians including Turkish (Saruhan‐Direskeneli et al ., ; Keskin et al ., ), Italian (Petrone et al ., ), German (Donner et al ., ) and Macedonian (Ilonen et al ., ) and even some of non‐Caucasian populations such as Asians (Park & Eisenbarth, ; Bugawan et al ., ) and Tunisians (Fekih Mrissa et al ., ). As expected, we found that DRB1*03:01, DRB1*04:02 and DQB1*02:01, DQB1*03:02 are highly significant disease‐associated alleles among our patients with T1D.…”

Section: Discussionmentioning

confidence: 97%

“…The protective alleles in this study consisted of DRB1*07:01, *11:01, *13:01, *14:01, *15 and DQB1*06:01, *06:02 and *06:03 alleles which is supported by previous limited number of observations in Iran [13, 14].However, few differences in distribution pattern of HLA class II alleles were observed among these Iranian samples which the conceivable explanation for that could be ethnic variations among Iranians. In spite of the presence of different ethnic groups in Iran, the main features of HLA class II alleles/haplotypes association for T1D are in accordance mainly with Caucasians relative to Asians and some of Africans (Saruhan‐Direskeneli et al ., ; Petrone et al ., ; Hermann et al ., ; Keskin et al ., ; Fekih Mrissa et al ., ).…”

Section: Discussionmentioning

confidence: 97%

“…The specific combination of DR-DQ haplotypes (diplotypes) is well known to affect T1D risk in many studies on Europeans, so that DR3/DR4 heterozygote patients confers the highest risk for T1D followed by DR3/DR3 and DR4/DR4 homozygote diplotype (Noble et al, 1996;Fekih Mrissa et al, 2013). Consistently, we observed the highly significant risk for DR3/DR4 diplotype (RR 18.80) relative to DR3/DR3 and DR4/DR4 genotypes among our patients with T1D which is in line with the hypothesis that transcomplementing DQ heterodimers present diabetogenic epitopes to T cells more effectively (Nepom et al, 1987;Reichstetter et al, 1999;Koeleman et al, 2004;Erlich et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

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HLA class II susceptibility pattern for type 1 diabetes (T1D) in an Iranian population

Kiani

Hajilooi

Fürst

et al. 2015

Int J Immunogenetics

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This study aimed to determine the HLA-DRB1/HLA-DQB1 susceptibility and protection pattern for type 1 diabetes (T1D) in a population from Hamadan, north-west of Iran. A total of 133 patients with T1D were tested for HLA-DRB1 and HLA-DQB1 alleles using PCR-SSP compared to 100 ethnic-matched healthy controls. Alleles and haplotypes frequencies were compared between both groups. The most susceptible alleles for disease were HLA-DRB1*03:01, DRB1*04:02, DQB1*02:01 and DQB1*03:02, and protective alleles were HLA-DRB1*07:01, *11:01, *13:01, *14:01 and DRB1*15 and HLA-DQB1*06:01, *06:02 and *06:03. Haplotype analysis revealed that patients with T1D had higher frequencies of DRB1*03:01-DQB1*02:01 (OR = 4.86, P < 10(-7) ) and DRB1*04:02-DQB1*03:02 (OR = 9.93, P < 10(-7) ) and lower frequencies of DRB1*07:01-DQB1*02:01 (P = 0.0005), DRB1*11:01-DQB1*03:01 (P = 0.001), DRB1*13:01-DQB1*06:03 (P = 0.002) and DRB1*15-DQB1*06:01 (P = 0.001) haplotypes compared to healthy controls. Heterozygote combination of both susceptible haplotypes (DR3/DR4) confers the highest risk for T1D (RR = 18.80, P = 4 × 10(-5) ). Additionally, patients with homozygote diplotype, DR3/DR3 and DR4/DR4, showed a similar risk with less extent to heterozygote combination (P = 0.0004 and P = 0.01, respectively). Our findings not only confirm earlier reports from Iranians but also are in line with Caucasians and partly with Asians and some African patients with T1D. Remarkable differences were the identification of DRB1*04:01-DQB1*03:02, DRB1*07:01-DQB1*03:03 and DRB1*16-DQB1*05:02 as neutral and DRB1*13:01-DQB1*06:03 as the most protective haplotypes in this study.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

HLA class II susceptibility pattern for type 1 diabetes (T1D) in an Iranian population

Kiani

Hajilooi

Fürst

et al. 2015

Int J Immunogenetics

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“…The following data were extracted from each study: the first author's name, publication year, country of study; number of cases and controls, HLA‐DRB1 alleles, for cases and controls, diagnostic method and HLA genotyping method. Three studies reported from Tunisia , two from Bahrain , two from Lebanon and two from Israel (subjects of Arabic origin) . There were one study from each of Algeria , Iraq , Morocco and Saudi Arabia .…”

Section: Methodsmentioning

confidence: 99%

The profile of HLA‐DRB1 alleles in Arabs with type 1 diabetes; meta‐analyses

Hamzeh

Nair

Ali

2015

HLA

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Genes from the HLA complex have a major contribution in type 1 diabetes (T1D), which results from an interplay between environmental and genetic factors. The latter can explain some of the geographic variability in T1D occurrence around the world. Of a particular importance in this regard are the HLA-DR, -DP and -DQ loci. Consequently, we aimed at elucidating the collective genetic profiles of various alleles relating to HLA-DRB1 and -DP in T1D patients throughout the Arab World using the tools of meta-analysis. As for HLA-DQA1 and DQB1 alleles; this analysis was completed and published previously (see Introduction). As a result of limited availability of relevant studies of the HLA-DP locus, only HLA-DRB1 alleles were tackled in this paper. Our study showed that significant increases in T1D risk resulted from harboring the alleles DRB1*03:01 and *04:05 (odds ratio 7.76 and 7.52, respectively). DRB1*04:01 and *04:02 were also predisposing for T1D in Arabs. Very strong evidence supported the protective effects of DRB1*10:01, *13:01, *15:02 and *16:01, with low heterogeneity and no publication bias. The results from the series of meta-analyses performed in this study help to complete the global genetic epidemiological map of T1D by providing statistically robust data from the Arab World.

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“…The following data were extracted from each study: the first author's name, publication year, country of study; number of cases and controls, HLA‐DQA1, HLA‐DQB1 alleles, and HLA DRB1‐DQ haplotypes for cases and controls, diagnostic method, and HLA genotyping method. Four studies reported from Tunisia , two from Bahrain , two from Lebanon , and two from Israel (subjects of Arabic origin) . There were one study from each of Algeria , Iraq , Kuwait , Morocco , Saudi Arabia , and Sudan .…”

Section: Methodsmentioning

confidence: 99%

Association of HLA‐DQA1 and ‐DQB1 alleles with type I diabetes in Arabs: a meta‐analyses

et al. 2015

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This study aimed at assessing the nature and significance of associations between various alleles of HLA-DQA1, HLA-DQB1, and type I diabetes (T1D) in Arab populations. Evidence from literature (published before 20 April 2015) was amassed and analysed through multiple meta-analyses, which yielded effect summary odds ratios and 95% confidence intervals for 24 alleles and 4 haplotypes. A total of 1273 cases and 1747 controls from 16 studies were analysed. High levels of significance were obtained to support higher T1D risk when harbouring DQA1*03:01. The alleles DQB1*02:01 and *03:02 and the haplotypes DR3 and DR4 were significant risk factors, albeit with high publication heterogeneity. The protective effects of DQA1*01:01, DQB1*05:03, *06:02, *06:03, and *06:04 were robustly suggested by all indicators of meta-analyses. The haplotypes DR7 and DR11 were strongly suggested to be protective in Arabs. A relatively small number of studies have emerged from Arab countries, mostly with inadequate power on an individual basis. This study fills the gap by providing significant size effect of human leukocyte antigen (HLA) alleles and completes the continuum of global ethnic differences in this context.

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Association of HLA-DR-DQ polymorphisms with diabetes in Tunisian patients

Cited by 22 publications

References 30 publications

HLA class II susceptibility pattern for type 1 diabetes (T1D) in an Iranian population

HLA class II susceptibility pattern for type 1 diabetes (T1D) in an Iranian population

The profile of HLA‐DRB1 alleles in Arabs with type 1 diabetes; meta‐analyses

Association of HLA‐DQA1 and ‐DQB1 alleles with type I diabetes in Arabs: a meta‐analyses

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