Association of HLA‐DQ4/5 genotype polymorphisms with celiac disease in a group of children in Southwest Iran: A case‐control study
Ali Keshtkari,
Marzieh Danaei,
Milad Mollaali
Abstract:Background and AimCeliac disease (CD) has proinflammatory and pathogenic immune responses to gluten in intestinal tissue, leading to structural changes in the mucosa of the small intestine. The association of human leukocyte antigen (HLA)‐DQ2 and DQ8 genotypes with CD has been previously reported. This test has a negative predictive value close to 100%, so its main purpose is to rule out the detection of CD completely or almost completely. There is limited information regarding HLA‐DQ4/5 in CD. This study was … Show more
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