Association of HLA B8 with spontaneous resolution in sarcoidosis.

Smith, Michael J.; Turton, Charles; Mitchell, D. N.; Turner-Warwick, M; Morris, Lauren; Lawler, SylviaD.

doi:10.1136/thx.36.4.296

Cited by 81 publications

(32 citation statements)

References 5 publications

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“…We found an increased frequency of HLA-A1 and B8 markers in the 59 patients as shown in table 1 in agreement with data previously published by ourselves [31] and others [32], We also studied a possible heter ogeneity of the disease: we confirmed the correlation found between HLA-B8 and dis ease resolution (either spontaneous or pred nisone-induced), reported elsewhere [32] and also with female sex, as shown in table 1. HLA-DR5 frequency was significanctly in creased in patients as a whole but even more so in males and in treatment-resistant or relapsing patients, as has been recently de- this marker by isoelectric focusing.…”

Section: Resultssupporting

confidence: 81%

Sarcoidosis and Major Histocompatibility Complex Genes with Special Emphasis on BF F Subtypes

et al. 1991

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Frequencies for HLA class I and II histoglobulins and C4A, C4B, BF complement proteins were performed for 59 sarcoidosis patients. The DR5 allele was present in 55.9% of patients as compared to 31.5% of controls. We noticed that its increase was more relevant in males and in those with a poor prognosis. BF F allele was significnatly overrepresented in patients (29.09 % vs. 19.15 % of control), especially in women. Special emphasis was given to BF F subtyping, to define an association between a particular BF F subtype and patient’s sex or disease outcome.

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Section: Resultssupporting

confidence: 81%

Sarcoidosis and Major Histocompatibility Complex Genes with Special Emphasis on BF F Subtypes

et al. 1991

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“…A large number of HLA class I and II alleles have been reported to be overrepresented in sarcoidosis, and especially HLA-DR3 was early recognized to associate with sarcoidosis in general and in particular with acute manifestations of the disease, such as EN and ankle arthritis or periarticular inflammation (i.e., features linked to a good prognosis) (10)(11)(12)(13). Subsequent studies have corroborated a strong association with specific HLA alleles (14) (i.e., HLA-DRB1*0301), and in such patients identified a typical lung accumulation of CD4 ϩ T cells expressing a particular T-cell receptor (TCR) for antigen, AV2S3, suggesting the presence of a specific antigen (15).…”

Section: What This Study Adds To the Fieldmentioning

confidence: 99%

Sex-Specific Manifestations of Löfgren's Syndrome

Grünewald

Eklúnd

2007

Am J Respir Crit Care Med

143

101

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Motivation: It has been debated whether patients need to have erythema nodosum to be classified as having Löfgren's syndrome. In this study, we have therefore in detail evaluated and compared a large number of patients with an acute onset of sarcoidosis and bilateral hilar lymphadenopathy (BHL), with or without erythema nodosum (EN). This study is important because it may lead to a more accurate definition of Löfgren's syndrome, and an exact phenotype of patients is crucial in modern medical research. Background: Löfgren's syndrome is commonly regarded as a distinct clinical entity. Methods: We have in detail evaluated a large group of patients (n ϭ 150) with an acute onset of sarcoidosis with BHL, in most cases with fever, EN, and/or bilateral ankle arthritis or periarticular inflammation. Within this group, 87 patients had EN (EN positive), whereas 63 were without EN (EN negative), though with distinct symmetric ankle inflammation. Results: EN-positive and EN-negative patients were identical in every aspect except that there were significantly more women in the ENpositive group: 58 women (67%) in the EN-positive group compared with only 17 (27%) women in the EN-negative group (p Ͻ 0.0001). In all other aspects, such as age, smoking habits, seasonal clustering of disease onset, rate of positive biopsies, chest radiography, pulmonary function, bronchoalveolar lavage cell distributions including the typically increased CD4/CD8 ratio, and clinical development of the disease, the EN-positive and EN-negative groups were close to identical. The two groups were also identically strongly associated with HLA-DRB1*0301/DQB1*0201, with 60 (69.0%) and 44 (69.8%) patients having this particular HLA type in the EN-positive and EN-negative groups, respectively. Such patients recovered to the same degree-that is, at almost 100%. Conclusions: We conclude that manifestations of Löfgren's syndrome differ between men and women, with EN found predominantly in women, whereas a marked periarticular inflammation of the ankles or ankle arthritis without EN is seen preferentially in men.

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“…The HLA-B8, DR3 haplotype has been associated with acute-onset, stage I resolving sarcoidosis [106][107][108][109] in Caucasians but not in West Indians [107]. HLA-DR5 has also been associated with sarcoidosis [103][104][105].…”

Section: Pulmonary Sarcoidosismentioning

confidence: 99%

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

Saltini¹,

Amicosante²,

Franchi³

et al. 1998

Eur Respir J

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The role of genetic factors has been hypothesized in the pathogenesis of a number of chronic inflammatory lung diseases. The genes of the major histocompatibility complex (MHC) locus on human chromosome 6 have been identified as important determinants in diseases caused both by inorganic and organic compounds such as beryllium, gold, acid anhydrides, isocyanates and grass pollens. Since many environmental factors are the determinants of the immunopathogenesis of asthma, pulmonary granulomatous disorders, hypersensitivity pneumonitis and fibrotic lung disorders, an understanding of the interaction between environmental factors is crucial to epidemiology, prevention and treatment of these disorders. Berylliosis is an environmental chronic inflammatory disorder of the lung caused by inhalation of beryllium dusts. A human leukocyte antigen class II marker (HLA-DP Glu69) has been found to be strongly associated with the disease. In in vitro studies, the gene has been shown to play a direct role in the immunopathogenesis of the disease. In human studies, the gene has been shown to confer increased susceptibility to beryllium in exposed workers, thus suggesting that HLA gene markers may be used as epidemiological probes to identify population groups at higher risk of environmental lung diseases, to identify environmental levels of lung immunotoxicants that would be safe for the entire population and to prevent disease risk associated with occupation, manufactured products and the environment. Studies on the associations between human leukocyte antigens and chronic inflammatory lung disorders are reviewed in the context of the berylliosis model.

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Association of HLA B8 with spontaneous resolution in sarcoidosis.

Cited by 81 publications

References 5 publications

Sarcoidosis and Major Histocompatibility Complex Genes with Special Emphasis on BF F Subtypes

Sarcoidosis and Major Histocompatibility Complex Genes with Special Emphasis on BF F Subtypes

Sex-Specific Manifestations of Löfgren's Syndrome

Immunogenetic basis of environmental lung disease: lessons from the berylliosis model

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