Association of HLA alleles with hematologic malignancies

Kazemi, Mohammad; Momeni-Varposhti, Zahra; Roshandel, Elham; Sankanian, Ghazaleh; Rouzbahani, Negin Hosseini; Ghorban, Khodayar; Rajaeinejad, Mohsen; Hajifathali, Abbas

doi:10.1016/j.genrep.2021.101346

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…Our study did not identify any association between HLA-DRB1 and DQB1 alleles and patients diagnosed with ALL and AML. Similarly, it has been reported that there is no association between HLA-DRB1 and/or DQB1 in leukemia patients with ALL and/or AML (14,(21)(22)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 85%

“…A substantial dataset on HLA-related leukemias is available. Studies have demonstrated links between HLA-DPB1*02:01 (8), DRB1*04 (9-13), DQB1*04 (14), B44 (15), DRB1*13 (15), and predisposition to acute leukemia development. Nevertheless, currently, no HLA allele or haplotype has found clinical application as a diagnostic or prognostic factor in leukemia.…”

Section: Introductionmentioning

confidence: 99%

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Frequencies of HLA Alleles in Patients with Acute Lymphoblastic and Myeloid Leukemia

Güleç,

Arslan

2023

Med Sci Discov

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Objective: Our objective was to investigate the potential correlation between human leukocyte antigens (HLA) - specifically, HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 genes - and patients diagnosed with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Material and Methods: We conducted an analysis of HLA allele frequencies among 393 patients with ALL, 431 patients with AML, and a control group comprising 564 healthy donors. Additionally, we explored the variation in HLA allele distribution between pediatric and adult patients diagnosed with ALL. Results: In comparison to the donor group, a heightened frequency of HLA-A*32 antigen was observed in AML patients (p=0.015, OR: 1.682). Conversely, the frequencies of HLA-B*55 (p=0.027, OR: 0.545) in ALL patients, HLA-B*14 (p=0.023, OR: 0.397), and HLA-B*55 (p=0.04, OR: 0.604) in AML patients were notably diminished. Notably, there were no discernible differences in HLA Class II allele frequency and analysis between the patient and control groups. Moreover, a significant distinction in the frequencies of HLA-A*25 (p=0.019, OR: 8.426) and DRB1*04 (p=0.049, OR: 1.491) was identified between pediatric patients (n=165) and adult patients (n=228) with ALL. Conclusion: The findings indicate that HLA-A*32 might serve as a genetic predisposing factor for AML, and HLA-A*25 and DRB1*04 could be potential genetic risk factors for pediatric ALL patients. Conversely, HLA-B*55 appears to be a potential protective factor against both forms of acute leukemia.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Frequencies of HLA Alleles in Patients with Acute Lymphoblastic and Myeloid Leukemia

Güleç,

Arslan

2023

Med Sci Discov

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“…All included patients received allogeneic stem cell transplants, which are fully matched in HLA-A, -B, -C, -DRB1, and -DQB1 loci. HLA typing was performed using a single specific primer-polymerase chain reaction (PCR-SSP) method as previously described (26). Patients were kept in isolated rooms with HEPA air filtration.…”

Section: Patientsmentioning

confidence: 99%

Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation

et al. 2022

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Background: T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune-checkpoint molecule that is upregulated following allogeneic immune responses and could play an important role in the development and pathogenesis of graft-versus-host disease (GVHD). The soluble form of TIM-3 (sTIM-3) is increased following the upregulation of membranous TIM-3. Objectives: The aim of this study was to evaluate the association between plasma level of sTIM-3 and acute GVHD (aGVHD) incidence in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Blood samples were collected from 42 allo-HSCT patients and 20 healthy individuals 2 weeks after allo-HSCT. The plasma level of sTIM-3 was measured using enzyme-linked immunosorbent assay (ELISA). The clinical and demographic data of patients were collected from the clinical documents. Data analysis was evaluated using student t-test and one-way ANOVA tests. P-values less than 0.05 were assumed statistically significant. Results: Among 18 (42.8%) patients with aGVHD symptoms, 10 (23.8%) had severe GVHD and 8 (19%) experienced mild GVHD. Plasma sTIM-3 levels at day +14 were significantly higher in patients who developed aGVHD compared to allo-HSCT patients without GVHD and also the healthy control individuals (P-value = 0.015 and < 0.001). Among the aGVHD patients, the sTIM-3 levels in those with severe GVHD were approximately 2.5 times higher than those with mild GVHD (P-value < 0.001). Conclusions: We have identified a high plasma level of sTIM-3 as a valuable biomarker in predicting the development of acute GVHD, especially severe aGVHD in allo-HSCT patients.

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HLA alleles, haplotypes frequencies, and their association with hematological disorders: a report from 1550 families whose patients underwent allogeneic bone marrow transplantation in Egypt

ElNahass,

Mekky,

Abdelfattah

et al. 2024

Immunogenetics

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Association of HLA alleles with hematologic malignancies

Cited by 4 publications

References 47 publications

Frequencies of HLA Alleles in Patients with Acute Lymphoblastic and Myeloid Leukemia

Frequencies of HLA Alleles in Patients with Acute Lymphoblastic and Myeloid Leukemia

Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predicts Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation

HLA alleles, haplotypes frequencies, and their association with hematological disorders: a report from 1550 families whose patients underwent allogeneic bone marrow transplantation in Egypt

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