Association of HLA-A9 and HLA-B5 with Buerger's disease.

McLoughlin, Gráinne; Helsby, C R; Evans, Cyril; Chapman, Doug

doi:10.1136/bmj.2.6045.1165

Cited by 89 publications

(26 citation statements)

References 7 publications

(1 reference statement)

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“…However, RA patients with vascular lesions showed a slight difference in association with HLA in comparison with RA patients without vasculitis; that is the absence of HLA-Bw44, which is consistent with the study by Toyoda et al (24). Since this HLA specificity was also absent in both Japanese and white patients with Buerger's disease (25,26), HLA-Bw44 seems to have a protective function against developing vascular lesions.…”

Section: Discussionsupporting

confidence: 89%

Suppressor t cell function in patients with rheumatoid arthritis complicated by vasculitis

Abe

Takeuchi

Koide

et al. 1984

Arthritis & Rheumatism

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Concanavalin A (Con A)—induced suppressor T cell activity was determined in 10 rheumatoid arthritis (RA) patients with vasculitis, 34 RA patients without vasculitis, and 10 healthy individuals. The percent Con A—induced suppression in RA patients with vasculitis was 24.6. In contrast, it was 68.4% in those RA patients without vascular lesions. Further, the proportion of T cells reactive with OKT8 monoclonal antibody was also decreased in RA patients with vasculitis. Accordingly, the reduced Con A—induced suppressor T cell activity in these RA patients resulted, in part, from the reduction in the number of cells of the suppressor T cell subset. Those patients with vascular lesions also had a higher percentage of positive antilymphocytotoxic antibodies than RA patients without vasculitis. Since the differences in Con A—induced suppressor T cell activity and frequency of positive antilymphocytotoxic antibodies were so great, we believe RA patients with vasculitis could be recognized as a disease group distinct from RA patients without vasculitis.

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Section: Discussionsupporting

confidence: 89%

Suppressor t cell function in patients with rheumatoid arthritis complicated by vasculitis

Abe

Takeuchi

Koide

et al. 1984

Arthritis & Rheumatism

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“…Another finding of interest is the greater prevalence of HLA-A9 and HLA-B5 antigens in patients with von Winiwarter-Bucrger's disease [McLoughlin et al, 1976]. In consis-tcnce with the findings of Buerger [ 1908], the disease shows an increased occurrence in Is rael and the Orient.…”

mentioning

confidence: 74%

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger’s Disease)

Berlit¹,

Kessler²,

Reuther³

et al. 1984

Eur Neurol

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The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected. Heavy smokers under 40 years of age have a high predisposition for the disease. The cerebral form shows relapsing brain infarctions which can be visualized in CCT while panarteriography remains negative. Apart from unspecific inflammatory signs in blood and CSF there are distinctive laboratory findings proving the autoimmunological character of von Winiwarter-Buerger’s disease. In the serum anti-elastin antibodies, IgE and anticollagen antibody activity are detectable. In 3 patients the authors detected specific immunohistochemical findings in a biopsy specimen of the temporal artery. In addition to platelet-inhibiting substances corticoids in acute and azathioprine in chronic treatment becomes necessary.

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“…This type of autoimmune phenomenon has been supported further by the presence of anticollagen antibodies in some patients with Buerger's disease (11). Furthermore, certain human leukocyte antigens (HLA) (types A9, B5, and DR4) have been reported to occur in a greater-than-expected frequency in patients with TAO, suggesting a possible genetic predisposition to this disease (12,13). HLA typing was not done for this patient because he was not considered a good renal transplant candidate.…”

Section: Discussionmentioning

confidence: 86%