Association of HIV serostatus and metabolic syndrome with neurobehavioral disturbances

Abstract

Your article is protected by copyright and all rights are held exclusively by Journal of NeuroVirology, Inc.. This e-offprint is for personal use only and shall not be selfarchived in electronic repositories. If you wish to self-archive your article, please use the accepted manuscript version for posting on your own website. You may further deposit the accepted manuscript version in any repository, provided it is only made publicly available 12 months after official publication or later and provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com".

Infectious disorders: HIV, hepatitis C, and COVID-19 pandemics.

“…ART itself has been implicated as a contributor to metabolic disorders, which are more prevalent among ART-treated women and older persons (Sashindran & Singh, 2021). The metabolic syndrome has been linked to self-report of apathy and executive dysfunction (Pope et al, 2020) as well as to deficits in learning, fine motor skills, and executive function in PWH, with diabetes and elevated triglycerides as the factors most strongly linked with worse overall neuropsychological performance (Yu et al, 2019). Researchers have also looked for evidence of premature and accelerated aging (Durand et al, 2017;Stoff et al, 2017).…”

Pathophysiological Consequences of At-Risk Alcohol Use; Implications for Comorbidity Risk in Persons Living With Human Immunodeficiency Virus

“…Alterations in these adipokines have been linked to metabolic dysregulation in obese subjects ( Harwood, 2012 ; Lee and Kwak, 2014 ), in PLWH on ART ( Jan et al, 2004 ; Lagathu et al, 2005 ), and to impaired insulin signaling ( Jan et al, 2004 ; Stankov and Behrens, 2010 ). CMS is a comorbidity commonly associated with cognitive deficits in PLWH ( Pope et al, 2020 ; Pasipanodya et al, 2021 ), and cardiometabolic health is linked to improved cognitive function in aging PLWH ( Saloner et al, 2019 ).…”

“…CMS has been linked to neurocognitive impairment in the general population ( Yaffe et al, 2004 ; Panza et al, 2010 ), particularly in the presence of inflammation. More recently, this link has been examined in the context of HIV infection, demonstrating an additive effect of HIV and CMS on neurocognitive dysfunction, including apathy and decreased executive function ( Pope et al, 2020 ), and impairments in the neurocognitive domains of learning and fine motor skills ( Yu et al, 2019 ). The neurological consequences of chronic HIV infection span both the peripheral and central nervous systems, and despite the success of ART to control viral loads, HIV infection and treatment continue to promote neurological and psychiatric co-morbidities that worsen disease outcomes and overall quality of life.…”