Association of High-Intensity Binge Drinking With Lipid and Liver Function Enzyme Levels

Rosoff, Daniel B.; Charlet, Katrin; Jung, Jeesun; Lee, Sang Hoon; Muench, Christine; Luo, Audrey; Longley, Martha; Mauro, Kelsey L.; Lohoff, Falk W.

doi:10.1001/jamanetworkopen.2019.5844

Cited by 48 publications

(34 citation statements)

References 52 publications

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“…Binge alcohol consumption was significantly associated with HDL-C, after adjusting for factors of binge drinking. The present results differed from the findings of Rosoff et al [ 20 ], who reported a significant association between high-volume binge drinking and high cholesterol, triglycerides, and liver function enzyme levels. Furthermore, Klatsky and Gunderson [ 21 ] reported a significant association between binge drinking and hypertension, which was different from the findings of the current study.…”

Section: Discussioncontrasting

confidence: 99%

The Relationship between Binge Drinking and Metabolic Syndrome Components amongst Young Adults Aged 21 to 31 Years: Ellisras Longitudinal Study

Monyeki

Siweya

Kemper

et al. 2020

IJERPH

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Background: Evidence is lacking on the effects of binge alcohol consumption on metabolic syndrome in the rural South African population. The purpose of this study was to investigate the association between binge drinking and components of metabolic syndrome (MetS) amongst Ellisras rural young adults aged 21 to 31 years who are part of the Ellisras Longitudinal Study. Methods: Logistic regression analysis was applied to a total of 624 participants (306 males and 318 females) aged 21 to 31 years who took part in the Ellisras Longitudinal Study (ELS). The model was adjusted for covariates, including smoking, age, and gender. Binge alcohol consumption was assessed using a standardised questionnaire that was validated for the Ellisras rural community. A standardised method of determining the components MetS was used after fasting blood samples were collected from all the participants. Results: Binge drinking remained significantly associated with low levels of high-density lipoprotein cholesterol (HDL-C) (OR = 2.64, 95% CI = 1.23–5.65), after being adjusted for smoking, age, and gender. Other MetS components were not predicted. Instead, gender remained significantly associated with all MetS components, except triglycerides, at multivariate analysis. Age retained significance at multivariate analysis with waist girth (OR = 2.13, 95% CI = 1.37–3.34), triglycerides (OR = 2.30, 95% CI = 1.05–5.02), and the MetS composite (OR = 1.65, 95% CI = 1.12–2.41). Conclusion: Binge drinking was significantly associated with lower levels of HDL-C. Future studies should investigate the relationship between alcohol abuse and the components of incident MetS in this population.

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Section: Discussioncontrasting

confidence: 99%

The Relationship between Binge Drinking and Metabolic Syndrome Components amongst Young Adults Aged 21 to 31 Years: Ellisras Longitudinal Study

Monyeki

Siweya

Kemper

et al. 2020

IJERPH

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“…Our findings also support the causal role of alcohol consumption in increasing HDL-C as reported in previous MR studies 18,26 and provides evidence for the finding after controlling for smoking behavior. While we were unable to evaluate the effects of heavy alcohol consumption on HDL-C levels, we recently reported a cross-sectional study findings that very heavy alcohol consumption (> 10 standard drinks for men and > 8 standard drinks for women) to be associated with increased HDL-C 46 , which suggests that alcohol may impact HDL-C levels across a range of alcohol consumption levels.…”

Section: Discussionmentioning

confidence: 92%

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

Rosoff

Smith

Mehta

et al. 2019

Preprint

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Alcohol and tobacco use, two major modifiable risk factors for cardiovascular disease (CVD), are often consumed together. Using large publicly available genome-wide association studies (results from > 940,000 participants), we conducted two-sample multivariable Mendelian randomization (MR) to simultaneously assess the independent effects of alcohol and tobacco use on CVD risk factors and events. We found genetic instruments associated with increased alcohol use, controlling for tobacco use, associated with increased high-density-lipoprotein-cholesterol (HDL-C), decreased triglycerides, but not with coronary heart disease (CHD), myocardial infarction (MI), nor stroke; and instruments for increased tobacco use, controlling for alcohol use, associated with decreased HDL-C, increased triglycerides, and increased risk of CHD and MI. Exploratory analysis found associations with HDL-C, LDL-C, and intermediate-densitylipoprotein metabolites. Consistency of results across complementary methods accommodating different MR assumptions strengthened causal inference, providing strong genetic evidence for the causal effects of modifiable lifestyle risk factors on CVD risk.

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“…Unfortunately, tobacco and alcohol are considered major cardiovascular risk factors. Drinking alcohol is known to raise both HDL-C and total cholesterol concentrations [30], and the concurrent use of tobacco and alcohol enhances these increases [31]. Although the mean values of HDL-and total cholesterol were not higher in SLT users (compared to nonusers), the mean values of concurrent current SLT and alcohol users increased, significantly for total cholesterol ( Table 2).…”

Section: Co-use Of Alcoholmentioning

confidence: 96%

Smokeless tobacco use: its prevalence and relationships with dental symptoms, nutritional status and blood pressure among rural women in Burkina Faso

Diendéré¹,

Zeba

Nikièma³

et al. 2020

Preprint

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Background: Sub-Saharan women use smokeless tobacco (SLT) more than smoked tobacco. Among Western Africa countries, the estimated weighted prevalence of SLT use in rural women was the highest in Burkina Faso (after Sierra Leone). This study aimed to assess the prevalence of SLT use and its associated factors among rural women in Burkina Faso by using nationally representative data. Methods : We used data from the 2013 STEPwise approach to Surveillance (STEPS) study, which provided sociodemographic, clinical (anthropometric, systolic blood pressure [SBP], diastolic blood pressure [DBP], dental symptoms), biological (total and high-density lipoprotein cholesterol and fasting blood sugar), and tobacco and alcohol consumption data. Data for 1730 rural women were used, and we performed Student’s, chi-squared and logistic regression. Results : The prevalence of current SLT use was 13.8% (95% CI: 12.2-15.5). Significant risks for SLT use were the presence of dental symptoms (adjusted odds ratio [aOR] = 2.59; p<0.001), undernourishment (aOR = 1.78; p<0.01), a decrease in waist circumference (aOR = 0.98; p<0.05), a decrease in DBP (aOR = 0.97; p<0.01), increase in SBP (aOR = 1.01; p<0.05), and an increase in differential blood pressure (aOR = 1.01; p<0.05). The co-use of alcohol was also a significant risk factor (aOR = 2.80; p<0.001). Conclusion : The prevalence of current SLT use was high among rural women in Burkina Faso, and significant concerns for users included alcohol co-use, the occurrence of dental symptoms, undernourishment, and an increase in differential blood pressure. National Public Health interventions are needed to reduce SLT use and its health-related concerns.

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Association of High-Intensity Binge Drinking With Lipid and Liver Function Enzyme Levels

Cited by 48 publications

References 52 publications

The Relationship between Binge Drinking and Metabolic Syndrome Components amongst Young Adults Aged 21 to 31 Years: Ellisras Longitudinal Study

The Relationship between Binge Drinking and Metabolic Syndrome Components amongst Young Adults Aged 21 to 31 Years: Ellisras Longitudinal Study

Evaluating the effects of alcohol and tobacco use on cardiovascular disease using multivariable Mendelian randomization

Smokeless tobacco use: its prevalence and relationships with dental symptoms, nutritional status and blood pressure among rural women in Burkina Faso

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