Association of High Homocysteine Levels With the Risk Stratification in Hypertensive Patients at Risk of Stroke

Hui, Pei; Han, Bing; Fu, Qiang; Zong, Zhenkun

doi:10.1016/j.clinthera.2016.03.007

Cited by 33 publications

(29 citation statements)

References 22 publications

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“…Previous studies have also confirmed the connection between Hhcy and dyslipidaemia, which is consistent with the results of present study [37]. The down-regulations of miR-145 and miR-143 in injured or atherosclerotic vessels are associated with proliferating, less differentiated smooth muscle cells [38].…”

Section: Discussionsupporting

confidence: 93%

Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia

Liu

Xuekelati

Zhang

et al. 2017

BMC Cardiovasc Disord

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BackgroundAn elevated level of homocysteine (Hcy) in the blood is designated hyperhomocysteinaemia (Hhcy) and is regarded as a strong risk factor for the development of atherosclerosis (ATH), although the association remains controversial. Considered to be essential gene expression regulators, micro-RNAs (miRNAs) modulate cardiovascular disease development and thus can be regarded as potential biomarkers and therapeutic targets in atherosclerosis. The aim of the current study is to investigate the expression levels of atherosclerosis-associated miR-143 and miR-145 in Hhcy patients and predict the progress of atherosclerosis in Hhcy patients.MethodsA total of 100 participants were enrolled and included normal control subjects (NC = 20), hyperhomocysteinaemia alone subjects (Hhcy = 25), hyperhomocysteinaemia and carotid artery atherosclerosis combined subjects (Hhcy + ATH = 30) and patients with standalone carotid artery atherosclerosis (ATH = 25). Plasma Hcy, supplementary biochemical parameters and carotid artery ultrasonography (USG) were measured in all participants. MicroRNA expression levels in the peripheral blood were calculated by real-time reverse transcription-polymerase chain reaction (qRT-PCR). The correlations of miR-143 and miR-145 with Hcy, blood lipid parameters and carotid artery atherosclerotic plaques were evaluated using Pearson’s correlation coefficients. Receiver operating characteristic (ROC) curve analyses were performed to evaluate the capacities of miR-143 and miR-145 for the detection of Hhcy and atherosclerosis patients.ResultsMiR-143 and miR-145 exhibited trends towards significance with stepwise decreases from the NC to Hhcy groups and then to the Hhcy + ATH and ATH groups. Similar results were observed in the carotid artery plaque group (Hhcy + ATH and ATH grups) compared with the no-plaque group (NC and Hhcy groups). The miR-143 expression level exhibited significant negative correlations with Hcy, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c). The miR-145 expression level exhibited significant negative correlations with Hcy, TC, triglyceride (TG) and LDL-c. MiR-143 and miR-145 exhibited the greatest area under the curves (AUCs) (0.775 and 0.681, respectively) for the detection of every Hhcy patient, including those in the Hhcy and Hhcy + ATH groups, from among all subjects.ConclusionThe results indicated that the levels of atherosclerosis-associated circulating miR-143 and miR-145 are linked to Hhcy. MiR-143 may be used as a potential non-invasive biomarkers of Hhcy and thus may be helpful in predicting the progress of atherosclerosis in Hhcy patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-017-0596-0) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia

Liu

Xuekelati

Zhang

et al. 2017

BMC Cardiovasc Disord

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“…In our study, the CT1 comorbidities consisted of hypertension, hyperlipidemia and CVD. Previous studies have revealed that people with vascular risk factors tend to die prematurely from stroke . Persistent gout or hyperuricemia might exacerbate vascular inflammation and atherosclerosis, accelerating the development of stroke.…”

Section: Discussionmentioning

confidence: 99%

Differential risk group of developing stroke among older women with gouty arthritis: A latent transition analysis

Huang

Chiang

Hsu

et al. 2019

Eur J Clin Investigation

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Objective Gout‐related comorbidities are intricate and its clinical features may demonstrate sex difference; however, few studies have evaluated the links between comorbidities and gout in a female population. The objectives of this study were to compare the aggregation and transitive trajectories of comorbidities of gout, and their consequences in female and male gout populations. Methods A prospective cohort study was conducted using data from the Taiwan National Health Insurance Research Database. A female and male gout population were followed up from 2000 to 2009 to identify the comorbidities of cardiovascular disease, hyperlipidemia, hypertension, diabetes mellitus (DM) and chronic kidney disease. The cumulative incidence of stroke from 2000 to 2010 was examined. A latent trajectory analysis was used to determine the transitive trajectories of the comorbidities of gout. Results Both female and male patients with gout had five risk cluster transition (CT) phenotypes of comorbidities within 10‐year follow‐up: CT1 and CT2, with various persistent comorbidities; CT3, with few persistent comorbidities; and CT4 and CT5, with transfer to cluster 1 from other clusters. The female participants in CT2 predominantly experienced DM and were associated with significantly increased risk of developing stroke. Conclusion Diabetes is a notable risk factor for the development of stroke in female patients with gout. Early assessment and management for the comorbidities of gout, particularly in DM, would effectively reduce future stroke risk in female gout population.

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“…Cardiovascular events can adversely affect brain health in general, especially the cognitive domain with aging. it is more pragmatic and informative to consider fHcy as a continuous variable and has to be adjusted for impaired renal function [5,6]. On the basis of what is known about the central role of homocysteine in modulating cardiovascular and cognitive outcome and the results of previous studies on fHcy levels to discriminate AD, and Mild Cognitive impairment (MCI) from normal control subjects we choose to define the cut-off Hcy to be >/=10.00 µmol/L, rather than the common accepted normal range of Hcy to fall within the range of 5 -15 μmol/L.…”

Section: A Study Protocolmentioning

confidence: 99%

“…Elevated Hcy levels confer increase in mortality from coronary heart disease (CHD), cardiovascular disease (CVD) and all-cause mortality [5][6][7][8]. A meta-analysis of twelve studies comprising 23623 subjects calculated the core elements of Hcy risk estimate: the pooled adjusted risk ratio (RR) and the corresponding 95% confidence levels [5].…”

Section: Introductionmentioning

confidence: 99%

Exploratory study of sublimed sulfur, in cognitively normal subjects and in Alzheimer’s dementia (AD) subjects: implications for Sulfur targeting Hydrogen sulfide (H2S)/Homocysteine (Hcy) and beta-galactosidase (GALAC)/Autophagy Signaling in AD

Chiu¹,

Khan²,

Badmaev³

et al. 2017

J Syst Integr Neurosci

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Introduction: There is mounting evidence to suggest that hyper-homocysteinemia (eHct) correlates with cognitive decline severity and cortical atrophy in AD. Hydrogen Sulfide (H 2 S) exerts neuroprotection through regulating Homocysteine (eHcy) signaling. Elemental sulfur can mediate H 2 S neuroprotection through the trans-sulfuration pathway and correct the the dysregulation of H 2 S /Hct signaling in AD. Sublimed Sulfur, formulated as SULMEDOL and approved for the treatment of lactose intolerance, activates gut beta-galactosidase (GALAC). We repurpose Sulmedol from lactose intolerance to likely CNS effect, since gut GALAC cross-talks with senescence-related GALAC expression in the brain. In view of the known regulatory function of GALAC in CNS endosomal-lysosomal autophagy system , we propose that SULMEDOL may rescue aberrant autophagy in AD.

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Association of High Homocysteine Levels With the Risk Stratification in Hypertensive Patients at Risk of Stroke

Cited by 33 publications

References 22 publications

Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia

Expression levels of atherosclerosis-associated miR-143 and miR-145 in the plasma of patients with hyperhomocysteinaemia

Differential risk group of developing stroke among older women with gouty arthritis: A latent transition analysis

Exploratory study of sublimed sulfur, in cognitively normal subjects and in Alzheimer’s dementia (AD) subjects: implications for Sulfur targeting Hydrogen sulfide (H2S)/Homocysteine (Hcy) and beta-galactosidase (GALAC)/Autophagy Signaling in AD

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