Association of high expression of CD44 in clinicopathological factors of endometrial cancer

Riana, Gina M; Pelupessy, Nugraha; Qadar, Sriwijaya; Miskad, Upik Anderiani; Zainuddin, Andi Alfian; Madya, Fatmawati; Lukas, Efendi

doi:10.23736/s2724-606x.23.05279-x

Cited by 2 publications

(1 citation statement)

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“…Growth and progression of endometrial tumors may be linked to suppression of T‐cell‐mediated antitumor immunity via CD276. High CD44 expression has been associated with advanced EC, poor differentiation, greater myometrial invasion, and lymphovascular invasion [ 36 , 37 ]. The reason for the different results obtained for CD44 requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Identification of a disulfidptosis‐related prognostic signature for prediction of the effect of treatment in patients with endometrial carcinoma

Peng,

Gao,

Cao

et al. 2024

Cancer Innovation

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BackgroundDisulfide, an essential compounds family, has diverse biological activity and can affect the dynamic balance between physiological and pathological states. A recently published study found that aberrant accumulation of disulfide had a lethal effect on cells. This mechanism of cell death, named disulfidptosis, differs from other known cell death mechanisms, including cuproptosis, apoptosis, necroptosis, and pyroptosis. The relationship between disulfidptosis and development of cancer, in particular endometrial carcinoma, remains unclear.MethodsTo address this knowledge gap, we performed a preliminary analysis of samples from The Cancer Genome Atlas database. The samples were divided equally into a training group and a test group. A total of 2308 differentially expressed genes were extracted, and 11 were used to construct a prognostic model.ResultsBased on the risk score calculated using the prognostic model, the samples were divided into a high‐risk group and a low‐risk group. Survival time, tumor mutation burden, and microsatellite instability scores differed significantly between the two groups. Furthermore, a between‐group difference in treatment effect was predicted. Comparison with other models in the literature indicated that this prognostic model had better predictive anility.ConclusionThe results of this study provide a general framework for understanding the relationship between disulfidptosis and endometrial cancer that could be used for clinical evaluation and selection of appropriate personalized treatment strategies.

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Section: Discussionmentioning

confidence: 99%