Association of hepatocellular carcinoma in North American patients with extrahepatic primary malignancies

Shah, Ifat A.; Alfsen, G. Cecilie

doi:10.1002/1097-0142(19950601)75:11<2784::aid-cncr2820751127>3.0.co;2-d

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“…They also found that patients with HCC and EHPMs were less likely to be chronically infected with Hepatitis B virus (HBV) or Hepatitis C virus (HCV) [3] . Retrospective studies of American, Japanese, and South Korean cohorts found similar correlations [4,9,10] .…”

Section: Discussionmentioning

confidence: 72%

Three primary malignancies in 17 years in a man with chronic hepatitis B

Block¹,

Shinn²,

Roth³

et al. 2019

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The occurrence of three primary malignancies in a single patient is an infrequent phenomonen with an estimated occurrence at 0.1%. Notably, patients with hepatocellular carcinoma (HCC) are particularly unlikely to develop extrahepatic primary malignancies. In this light, we present a case of patient with chronic hepatitis B who developed HCC, as well as two other primary malignancies. This case exhibits an exceedingly rare combination of cancers, underlining the importance of continued cancer surveillence in those with a history of primary malignancy.

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