Association of Helicobacter pylori Infection and Height of Mexican Children of Low Socioeconomic Level Attending Boarding Schools

Vilchis, Jenny; Duque, Ximena; Mera, Robertino; Morán, Segundo; Torres, Javier; González-Cossı́o, Teresa; Kageyama-Escobar, María de la Luz; Navarro, Fabiola; Mendoza, Eugenia; Correa, Pelayo

doi:10.4269/ajtmh.2009.09-0107

Cited by 27 publications

(32 citation statements)

References 33 publications

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“…Interestingly, Hp+ patients were on average smaller than Hp– patients in our study. This finding is in line with findings of the previous studies performed in non‐severely obese patients (14, 15). While the biological background for this observation remains to be explored, it is interesting to note that smaller subjects appear to be more susceptible to acquire an Hp infection than tall subjects independent of their adiposity state.…”

Section: Discussionsupporting

confidence: 93%

Gastric Helicobacter pylori infection is associated with adverse metabolic traits in severely obese subjects

Gerig

Ernst

Wilms

et al. 2013

Obesity

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Objective: Asian studies have reported on an association of Helicobacter pylori (Hp) infection with insulin resistance (IR) in normal-weight subjects. Whether such an association likewise exists in European subjects with severe obesity was questioned. Design and Methods: To address this question, 370 severely obese patients from our database were identified, who had undergone a gastroscopy with a histological examination of gastric mucosal biopsies and a concurrent assessment metabolic blood parameters as a standard examination before bariatric surgery. Results: Seventy-five (20.3%) of the subjects displayed a histologically proven Hp infection (Hpþ). Sex distribution, age, and body mass index of Hpþ subjects did not differ from that of the subjects with no Hp infection (Hp-; all P > 0.293), but Hpþ subjects were significantly smaller (P ¼ 0.006). Fasting glucose, insulin, high-sensitive C reactive protein, and alanine aminotransferase levels as well as calculated indices of IR (i.e., HOMA-IR, QUICKI) did not differ between Hpþ and Hp-subjects (all P > 0.42). However, Hpþ subjects showed significantly higher triglyceride levels and a higher total chloesterol-to-HDL ratio but lower sex-hormone binding globulin (SHGB) levels than Hp-subjects (all P 0.05). Conclusion: While our results obtained in European severely obese patients do not provide evidence for an enhanced IR state associated with gastric Hp infection, they suggest that the presence of the bacterium in gastric biopsies is associated with an adverse lipid profile and reduced SHGB levels.

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Section: Discussionsupporting

confidence: 93%

Gastric Helicobacter pylori infection is associated with adverse metabolic traits in severely obese subjects

Gerig

Ernst

Wilms

et al. 2013

Obesity

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“…These differences could be related to socioeconomic and demographic characteristics of these populations; the indigenous population frequently resides in rural and semirural areas, often under poor sanitary conditions at low socioeconomic and health levels, and in more crowded circumstances than urban populations (25–27). …”

Section: Discussionmentioning

confidence: 99%

Natural History of Helicobacter pylori Infection in Mexican Schoolchildren

Duque

Vilchis

Mera

et al. 2012

J. pediatr. gastroenterol. nutr.

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Objectives The aim of the present study was to estimate the incidence and spontaneous clearance rate of Helicobacter pylori infection and the effect of some variables on these outcomes in schoolchildren. Methods From May 2005 to December 2010, 718 schoolchildren enrolled in 3 public boarding schools in Mexico City participated in the follow-up. At the beginning of the study and every 6 months thereafter, breath samples were taken to detect H pylori infection; blood samples and anthropometric measurements were taken to evaluate nutritional status. Data on sociodemographic characteristics were collected. Results The prevalence of H pylori infection was 38%. The incidence rate was 6.36%/year. Schoolchildren with anemia or iron deficiency at the beginning of the study (who received iron supplements) showed a higher infection acquisition rate than those with normal iron nutritional status, hazard ratio (HR) 12.52 (95% confidence interval [CI] 4.01%–39.12%), P <0.001 and HR 2.05 (95% CI 1.09%–3.87%), P = 0.027, respectively. The spontaneous clearance rate of the infection was 4.74%/year. The spontaneous clearance rate was higher in children who had iron deficiency (who received iron supplements), HR 5.02 (95% CI 1.33%–18.99%), P = 0.017, compared with those with normal nutritional iron status. It was lower in schoolchildren with ≥2 siblings compared with schoolchildren with 1 or no siblings, HR 0.23 (95% CI 0.08%–0.63%), P = 0.004. Conclusions H pylori infection status is dynamic in schoolchildren. Variables related to health status and infection transmission, such as iron status and number of siblings, are important for the incidence and spontaneous clearance of H pylori infection.

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“…An apparent negative impact of H. pylori infection on growth velocity or height has been documented in cohort studies in infants 6,7,8 and school age children 9 , as well in several well designed cross-sectional studies 10,11,12 . Although the amount and quality of the evidence seems to support the association of H. pylori infection and growth, it is not known whether attained height and weight in children will be impacted over the long term.…”

Section: Introductionmentioning

confidence: 89%

Long-term Effects of Clearing Helicobacter pylori on Growth in School-age Children

Mera¹,

Bravo²,

Goodman³

et al. 2012

Pediatric Infectious Disease Journal

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Background A new H. pylori infection affects growth velocity negatively, and clearing the infection produces a small significant rebound, but it is not known whether height and weight in children are impacted over the long term. Methods We investigated 295 school-age children followed in two cohorts, one treated (150) and one untreated (145), from 2004 for 3.7 years with 1105 child-years of observation. Follow-up intervals were 3 months for anthropometry measurements and 6 months for H. pylori status ascertained by urea breath test. Height in centimeters and weight in kilograms were analyzed using growth models. Results A multivariate mixed model that adjusted for age, sex, father’s education and number of siblings found no significant differences in height or weight at baseline by H. pylori status. The same model showed a significant impact of clearing H. pylori across time, with increasing significant differences in average height and weight as the follow-up progressed. Conclusions Children who were always negative or who cleared the infection grew significantly faster than those who stayed positive after adjusting for other covariates. This study suggests that school age children’s growth benefits from being treated for H. pylori infection.

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Association of Helicobacter pylori Infection and Height of Mexican Children of Low Socioeconomic Level Attending Boarding Schools

Cited by 27 publications

References 33 publications

Gastric Helicobacter pylori infection is associated with adverse metabolic traits in severely obese subjects

Gastric Helicobacter pylori infection is associated with adverse metabolic traits in severely obese subjects

Natural History of Helicobacter pylori Infection in Mexican Schoolchildren

Long-term Effects of Clearing Helicobacter pylori on Growth in School-age Children

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