Association of Helicobacter pylori infection with colorectal adenoma in the Chinese urban population: A cross-sectional study

Shen, Lingyu; Bian, Rongwen; Wang, Wei; Zhao, Jijun

doi:10.1016/j.micpath.2021.105111

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…Demographic characteristics were obtained from a questionnaire completed after enrollment and included age, gender, BMI, highest educational attainment, smoking status, alcohol intake, and personal medical history, including medication history, chronic diseases, and nutritional status. Blood samples were collected in the morning after a 12-hour overnight fast, and clinical indicators such as fasting blood glucose, hemoglobin A1c (HbA1c), lipid profiles, uric acid (UA), blood urea nitrogen (BUN), serum creatinine (Scr), alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid-stimulating hormone (TSH), hemoglobin (Hb), albumin (ALB), and C-reactive protein (CRP) were measured in the hospital clinical laboratory [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study

Shen

Zhu

et al. 2022

BMC Geriatr

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Objective Hyperhomocysteinemia (HHcy) is considered to increase the risk of sarcopenia (S) and remains controversial. In this study, we aimed to investigate the prevalence of S among older Chinese adults and explore whether homocysteine (Hcy) was independently associated with S. Methods This cross-sectional study was performed among older adults hospitalized in the Geriatric Hospital of Nanjing Medical University between June 2017 and December 2021. We measured all participants’ serum Hcy levels, hand grip strength, gait speed and appendicular skeletal muscle index(ASMI) using bioelectrical impedance analysis (BIA). S was defined based on the criteria of the Asian Working Group for Sarcopenia 2 (AWGS2), which included muscle mass (ASMI< 7.0 kg/m2 for men and ASMI< 5.7 kg/m2 for women by BIA) and low muscle strength (handgrip strength < 28 kg for men and < 18 kg for women), and/or gait speed < 1.0 m/s. HHcy defined as Hcy ≥10 μmol/L. The strength of the association between Hcy and the risk of S was analyzed by multivariate logistic regression using three models that adjusted for possible confounding variables to calculate the odds ratios (ORs) and 95% confidence intervals (CIs). Results Among the 441 subjects, 161 (36.5%) were diagnosed with S, and 343 (77.8%) were diagnosed with HHcy. A significant association was detected between S and serum Hcy per 1-μmol/L increase after adjustment for age, gender, education, smoking, body mass index (BMI), Mini Nutritional Assessment Short Form (MNA-SF), alanine aminotransferase (ALT), C-reactive protein (CRP), hemoglobin (Hb), albumin (ALB), diabetes, kidney disease, and statin use (OR = 1.07, 95% CI = 1.03–1.12, P = 0.002). The OR for S in the HHcy group (≥10 μmol/L) was nearly 5-fold that in the normal Hcy group (OR 4.96, 95% CI 2.67–9.24, P < 0.001). In a gender-based subgroup analysis that adjusted for age, education, smoking, BMI, MNA-SF, ALT, CRP, Hb, and ALB, female subjects with HHcy had an increased risk of S (OR 10.35, 95% CI 2.84–37.68, P < 0.001). Conclusions Our results demonstrated that elevated Hcy levels have an independent association with S in older adults. This suggests that the downward adjustment of HHcy (cutoff value < 10 μmol/l) might decrease the risk of S.

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Section: Methodsmentioning

confidence: 99%

Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study

Shen

Zhu

et al. 2022

BMC Geriatr

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“…Baseline characteristics were obtained from a questionnaire completed after enrollment, including age, gender, body mass index(BMI), highest educational attainment, smoking status, alcohol intake, and personal medical history. Blood samples were collected in the morning after a 12-hour overnight fast and clinical indicators such as fasting blood glucose, hemoglobin A1C (HbA1c), lipid pro les, uric acid (UA), blood urea nitrogen (BUN), serum creatinine (Scr), alanine aminotransferase (ALT), aspartate aminotransferase (AST), thyroid stimulating hormone (TSH), hemoglobin (Hb), albumin (ALB), C-reactive protein (CRP) were measured by the hospital clinical laboratory [13].…”

Section: Data Collectionmentioning

confidence: 99%

Association between serum homocysteine and sarcopenia in the Chinese elderly population: A cross-sectional study

Shen

Zhu

et al. 2022

Preprint

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Objection: Hyperhomocysteine (HHcy) is considered to increase the risk of Sarcopenia (SA) and remains controversial. In this study, we aimed to evaluate the association between homocysteine (Hcy) and SA in the Chinese elderly population. Methods: A cross-sectional study of 441 elderly patients, who underwent the measurements of muscle mass, muscle strength, physical performance, and serum Hcy from 2017 to 2021 at Geriatric Hospital of Nanjing Medical University, was carried out to assess the relationship between SA and Hcy. All baseline characteristics and laboratory examination of subjects were collected and analyzed by specific personnel. The strength of association between Hcy and the risk of SA was analyzed by multivariate logistic regression to calculate the odds ratios (ORs) and 95% confidence interval (CI). Results: Among the 441 subjects, 161 (36.51%) cases were diagnosed as SA, and 343 of them were found with HHcy. A significant association was detected between SA and serum Hcy per 1μmol/L increase(adjusted OR = 1.068, 95% CI = 1.021–1.117, p =0.004). In a gender-based subgroup analysis, the subjects with HHcy had an increased risk of SA in female group (adjusted OR 1.098, 95%CI 1.009–1.197, p = 0.036), but not in males. Furthermore, HHcy had a significantly positively associated with SA in the very elderly whose age was more than or equal to 85 (adjusted OR = 1.112, 95% CI = 1.037–1.193, P = 0.003).Conclusions: Hcy has a positive association with SA in Chinese urban population, especially in the elderly females. That suggests a hypothesis that the downward adjustment of Hcy might decrease the risk of SA.

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“…Gastritis, duodenal ulcers, gastric cancer, and other GI and non-GI problems have all been found to be associated with H. pylori infection 5 . Epidemiological studies have recently focused on the association between H. pylori infection and CRC 6 , 7 . There is also evidence that a high incidence of H. pylori seropositivity in patients with CRC 8 , 9 despite several reports stating that H. pylori infection has no role in the genesis of CRC 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

No evident causal association between Helicobacter pylori infection and colorectal cancer: a bidirectional mendelian randomization study

Luo,

Zhou,

Ran

et al. 2023

Sci Rep

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Observational studies have reported a correlation between Helicobacter pylori infection and colorectal cancer (CRC); however, the underlying cause has remained unclear. This research was aimed at determining whether there is a correlation between H. pylori infection and CRC by measuring the prevalence of H. pylori CagA antibodies and VacA antibodies. Using data from many genome-wide association studies (GWAS), we conducted a Mendelian randomization (MR) study with two sample GWAS. Then, we used bidirectional MR to evaluate the association between H. pylori infection and CRC for identifying causation. The most common method of analysis was the inverse variance-weighted technique. In addition, we performed supplementary analyses using the weighted median technique and MR-Egger regression. Horizontal pleiotropic outliers were identified and corrected using the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) method. Genetically predicted anti-H. pylori IgG seropositivity was not causally associated with CRC [odds ratio (OR): 1.12; 95% confidence interval (CI): 0.98–1.27, P = 0.08] and neither were H. pylori VacA antibody levels (OR = 0.96, 95% CI: 0.90–1.02, P = 0.25) or H. pylori CagA antibody levels (OR = 1.00, 95% CI: 0.93–1.07, P = 0.92). Furthermore, reverse MR analysis did not reveal evidence for a causal effect of CRC on H. pylori infection. The weighted median, the MR-Egger method, and MR-PRESSO yielded identical results. Using genetic data, MR analysis showed there was no evidence for a causal association between seroprevalence of H. pylori infection and CRC. The relationship between H. pylori infection and CRC requires further research.

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Association of Helicobacter pylori infection with colorectal adenoma in the Chinese urban population: A cross-sectional study

Cited by 5 publications

References 19 publications

Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study

Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study

Association between serum homocysteine and sarcopenia in the Chinese elderly population: A cross-sectional study

No evident causal association between Helicobacter pylori infection and colorectal cancer: a bidirectional mendelian randomization study

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