Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors

Patel, Praful; Mendall, M. A.; Carrington, David; Strachan, David P.; Leatham, E; Molineaux, N.; Levy, J.; Blakeston, C; Seymour, Carol A.; Camm, A. John

doi:10.1136/bmj.311.7007.711

Cited by 534 publications

(339 citation statements)

References 25 publications

Supporting

Mentioning

311

Contrasting

Unclassified

Order By: Relevance

“…Acredita-se que mais de um terço dos carcinomas gástri-cos seja atribuído à infecção pelo H. pylori. 26,33,73,100 Outras afecções associadas à infecção pelo H. pylori são linfoma de tecido linfóide associado à mucosa gástrica -MALToma, 105 dispepsia não-ulcerativa, 10,12 doenças coronarianas e cardiovasculares, 90,108,98,107 urticária idiopática crônica, 29,110,129 doenças auto-imunes (púrpura de Henoch-Shönlein, 77,111 trombocitopenia auto-imune, 43 síndrome de Sjögren 37 ) e enxaqueca. 42 Estudos sugerem que existe aumento na incidên-cia de refluxo gastroesofágico (RGE) após erradicação do H. pylori da mucosa gástrica.…”

Section: Introductionunclassified

See 1 more Smart Citation

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

View full text Add to dashboard Cite

Descritores ResumoRealizou-se revisão da epidemiologia da infecção pelo Helicobacter pylori, com o objetivo de analisar sua importância na infância e adolescência no que se refere à incidência, à prevalência, às vias de transmissão e aos fatores de risco. Para tanto, realizou-se uma pesquisa nas bases de dados Lilacs (OPS/Bireme) e Medline (National Library of Medicine) e no banco de teses da Universidade de São Paulo dos anos de 1983 a 1999. A análise da literatura levou à conclusão de que a infecção pelo Helicobacter pylori é adquirida principalmente durante a infância, apresenta aumento da prevalência com a idade, os principais fatores de riscos estão relacionados ao baixo nível socioeconômico e o mecanismo de transmissão permanece desconhecido. AbstractThe scope of the review is to study the epidemiological aspects of Helicobacter pylori infection and its importance during childhood and adolescence, focusing on incidence, prevalence, transmission and risk factors. The study's references included the following databases: LILACS (PAHO/ Bireme), MEDLINE, the US's National Library of Medicine and the thesis developed at University of São Paulo for the period 1983 to 1999. It was noted that Helicobacter pylori infection is mainly acquired during childhood, age-related prevalence, main risk factors are associated to low socioeconomic status, and its transmission mechanism remains unclear.

show abstract

Section: Introductionunclassified

“…106,107 A real importância desse agente nessa faixa etária, porém, é assunto que gera muita polêmica.…”

Section: Introductionunclassified

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

2002

View full text Add to dashboard Cite

show abstract

“…Thus, there is a possibility that the pharmacokinetics of pitavastatin might be modified by H. pyloriinduced severe chronic gastritis. Some infectious diseases, such as Chlamydia pneumoniae infection, have been considered as risk factors for coronary heart disease (18), and several studies have pointed to an association between H. pylori infection and vascular changes due to the alteration of the serum lipid profile (19,38). Previous studies reported that the serum T-Chol, TG, or LDL concentrations in H. pylori-infected persons are significantly elevated over those in noninfected individuals (39,40).…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori (H. pylori) is now recognized as a major risk factor for chronic active gastritis and stomach cancer development (16,17). In addition, it has been suggested to be also associated with coronary heart disease due to the alteration of the serum lipid profile (18,19). Therefore, there is a possibility that H. pylori infection might influence the pharmacologic activity of statins.…”

mentioning

confidence: 99%

Pitavastatin Fails to Lower Serum Lipid Levels or Inhibit Gastric Carcinogenesis in Helicobacter pylori–Infected Rodent Models

Toyoda

Tsukamoto²,

Takasu

et al. 2009

Cancer Prevention Research

View full text Add to dashboard Cite

Statins are commonly used lipid-lowering drugs that reduce the risk of cardiovascular morbidity and mortality. Although recent studies have pointed to chemopreventive effects of statins against various cancers, their efficacy for gastric cancer is unclear. Here, we examined the effects of pitavastatin, a lipophilic statin, on Helicobacter pylori (H. pylori)-associated stomach carcinogenesis and gastritis using Mongolian gerbil and mouse models. The animals were allocated to H. pylori + N-methyl-N-nitrosourea administration (gerbils, 52 weeks) or H. pylori infection alone groups (gerbils and mice, 12 weeks). After H. pylori infection, they were fed basal diets containing 0 to 10 ppm of pitavastatin. The incidences of H. pylori-associated gastric adenocarcinomas and degrees of chronic gastritis were not decreased by pitavastatin compared with those of control values. Expression of interleukin-1β and tumor necrosis factor-α mRNAs in the pyloric mucosa was markedly up-regulated in pitavastatin-treated animals. Furthermore, in the H. pyloriinfected groups, serum total cholesterol, triglyceride, and low-density lipoprotein levels were significantly increased by pitavastatin treatment, contrary to expectation. In the short-term study, H. pylori-infected gerbils and mice also showed significant up-regulation of serum triglyceride levels by pitavastatin, whereas total cholesterol was markedly reduced and low-density lipoprotein exhibited a tendency for decrease in noninfected animals. These findings indicate pitavastatin to be ineffective for suppressing gastritis and chemoprevention of gastric carcinogenesis in H. pylori-infected gerbils. Our serologic results also suggest that the H. pylori infection and consequent severe chronic gastritis interfere with the cholesterol-lowering effects of pitavastatin.

show abstract

“…In addition, Helicobacter pylori infection has been associated with atherosclerosis and MI. However, this correlation is unclear at this time (Patel et al 1995;Gunn et al 2000). Finally, Prasad (2003a) reported that the total amount of pathogens to which a patient is exposed is termed the pathogen burden, and it is perhaps related to the existence and complexity of CAD, and is possibly a better indicator of endothelial dysfunction than any one particular pathogen.…”

Section: Other Pathogensmentioning

confidence: 99%

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

et al. 2006

View full text Add to dashboard Cite

Restenosis is one of the major adverse outcomes of Percutaneous CoronaryIntervention (PCI). Previous studies have shown conflicting reports for homocysteine as a predictor of restenosis following PCI. The conflicting reports may be due to oxidative factors (stimulation of polymorphonuclear leukocyte [PMNL]-induced reactive oxygen species generation, xanthine-xanthine oxidase, and arachidonic acid metabolism) other than homocysteine which could cause endothelial cell dysfunction leading to restenosis.Malondialdehyde (MDA), a lipid peroxidation product, is a marker for oxidative stress and is related to all oxidative factors. Therefore, it is possible that serum MDA may be a better predictor of restenosis than plasma homocysteine. The purpose of this study is to determine whether or not the pre-procedural serum MDA and plasma homocysteine levels are elevated in patients who develop restenosis post PCI.The study included fifty-one patients undergoing elective PCI who consented to participate in a protocol that was approved by the Ethics Committee of the University of Saskatchewan. Homocysteine and malondialdehyde were measured in the plasma and serum respectively. Blood samples were collected pre-procedural, 0 time, 8 hours, 24 hours, and 6 months post-procedure. Exercise tolerance tests were performed at two weeks, and six months post-procedure to determine if there was any evidence of restenosis.The results of the study showed that pre-procedural values of plasma homocysteine in the restenosis and non-restenosis groups were 10.37 ± 0.46 and 10.73 ± 0.49 respectively. These values were not significantly different (p=0.60) between the groups. The pre-procedural levels of plasma homocysteine were not significantly ii different (p=0.08) from the post-PCI values of those patients who did not develop restenosis at the 6-month time interval. However, the pre-procedural levels of plasma homocysteine were significantly different from the post-PCI values of those patients in the restenosis group at the 24hr (p=0.04) and 6-month (p=0.002) time intervals. In the restenosis group there was a significant increase (24%) after six months in the values of homocysteine from the pre-procedural levels. Thus, this indicates that restenosis is associated with higher post-PCI levels of homocysteine.The pre-procedural levels of serum MDA in the restenosis and non-restenosis groups were 0.124± 0.16 and 0.147± 0.02 respectively. There was no significant difference (p=0.60) between the two groups. There was also no significant difference The results suggest that pre-procedural levels of plasma homocysteine and serum MDA were not predictors of restenosis following PCI. However, the post-PCI sixmonth levels of both homocysteine and MDA are predictors of restenosis. Moreover, the post-PCI levels of MDA were better predictors of restenosis than the post-PCI levels of homocysteine because the increase in MDA levels were greater at six months than the rise in homocysteine levels at the same time interval.iii ACKNOWLEDGEMENTS

show abstract

Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors

Cited by 534 publications

References 25 publications

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Aspectos epidemiológicos do Helicobacter pylori na infância e adolescência

Pitavastatin Fails to Lower Serum Lipid Levels or Inhibit Gastric Carcinogenesis in Helicobacter pylori–Infected Rodent Models

Homocysteine and Malondialdehyde as Predictors of Restenosis Following Percutaneous Coronary Intervention

Contact Info

Product

Resources

About