Association of heartbeat complexity with survival in advanced non-small cell lung cancer patients

Wu, Shuang; Li, Guangqiao; Chen, Man; Zhang, Sai; Zhou, Yu‐Fu; Shi, Bo; Zhang, Xiaochun

doi:10.3389/fnins.2023.1113225

Cited by 2 publications

(1 citation statement)

References 61 publications

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“…Excessive activity was avoided during collection, and the environment was kept quiet and at room temperature (24 ± 1°C). TP, LF, HF, and LF/HF of the frequency domain analysis and SDNN and RMSSD of the time domain analysis were selected to assess overall HRV, vagal activity, sympathetic activity, and sympathetic-vagal balance (Wu et al, 2023). Parameter analyses were performed using the Kubios HRV version 3.1.0 software (Kubios Oy: Kuopio, Finland).…”

Section: Indicators Of Heart Rate Variability (Hrv)mentioning

confidence: 99%

Effect of “needle sensation” and the real-time changes in autonomic nervous system activity during acupuncture analgesia

Liu,

Huang,

Yan

et al. 2024

Front. Neurosci.

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IntroductionAcupuncture analgesia (AA) is widely used in clinical practice. The autonomic nervous system (ANS) may be an important pathway for acupuncture signal transduction. However, real-time changes in autonomic function during AA and the effect of “needle sensation” remain unclear.MethodsWe established a human pain model in healthy adults and randomly assigned 128 participants to the model, sham acupuncture, and acupuncture groups in a 1:1:2 ratio. Heart rate variability (HRV), including total power (TP), low-frequency power (LF), high-frequency power (HF), ratio of LF to HF (LF/HF), standard deviation of the normal-normal intervals (SDNN), and root mean square of successive interval differences (RMSSD), were used to assess autonomic function. The visual analog scale (VAS) and efficiency were used to assess the analgesic effect of acupuncture. The Massachusetts General Hospital acupuncture sensation scale (MASS) was used to indicate the intensity of the needle sensation. Anxiety levels were also measured. Finally, the correlation of MASS with HRV, VAS, and anxiety levels was analyzed.ResultsVAS decreased after 10 min of needling and 5 min after needle withdrawal in the acupuncture group compared with those in the model group (p = 0.038, p = 0.020). The efficacy rates were 82.0, 50.0, and 61.3% in the acupuncture, model, and sham groups, respectively. These represent significant differences between the acupuncture group and the model and sham acupuncture groups (p < 0.001 in each case). No differences were observed between the model and sham acupuncture groups. HF, TP, SDNN, and RMSSD were all increased in the acupuncture group compared with those in the model group (p = 0.045, p = 0.041, p = 0.002, p = 0.006, respectively). No differences were observed in the sham acupuncture group compared to the model group (p = 0.632, p = 0.542, p = 0.093, p = 0.222, respectively). The LF and LF/HF did not differ among all three groups. A positive correlation was observed between MASS and RMSSD2, LF2, RMSSD4, TP4, VAS5, and anxiety levels.ConclusionAA was associated with enhanced vagal activity. The intensity of needle sensation was positively correlated with vagal and sympathetic nerve activities. Acupuncture is an effective means of regulating autonomic function, and needle sensation may be an important modulator.

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Section: Indicators Of Heart Rate Variability (Hrv)mentioning

confidence: 99%

Effect of “needle sensation” and the real-time changes in autonomic nervous system activity during acupuncture analgesia

Liu,

Huang,

Yan

et al. 2024

Front. Neurosci.

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The Prognostic Correlation of Heart rate variability and body weight status in liver cancer patients

Huang,

Liang,

Feng

et al. 2024

Preprint

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Background Weight status play an important role in the evolution and prognosis of cancer patients; however alterations of autonomic nervous system (ANS) caused by cancer may be the associated symptoms in cancer-related weight change. Objective The aim of this study is to identify the influence of weight status on ANS and determine whether ANS can be used as an index for early detection and prediction of weight changes in liver cancer patients with HRV. Methods We conducted a retrospective analysis of clinical data for newly diagnosed liver cancer from 2017 to 2022 in China. The authors conducted clinical and ECG data of liver cancer with special emphasis on advances ECG and the BMI aspect. Results Both BMI and KPS were lower in the liver cancer group compared to benign tumor patients and healthy controls (p ≤ 0.001). Liver cancer patients were more likely to have a history of diabetes (p = 0.005) and hepatitis B virus infection (p ≤ 0.001) compared to non-liver cancer patients. Moreover, the HRV indices and variations remained low in liver cancer patients Additionally, the mean average levels of SDNN and VLF bands in liver cancer remained significantly low (p ≤ 0.005). The results reveal that a lower BMI, lower VLF index, together with history of HBV infection positively correlated in liver cancer patients. The study reveals that HRV indices is associated with BMI in liver cancer patients with lesser body weight. As predicted, the LF and LF/VLF scores had correlation with lower BMI in the liver cancer patients (p < 0.05). Conclusion In liver cancer patients, decreased HRV was associated with a lower BMI independent of other con-founders. The role of HRV as a potential index for predicting cancer-related weight loss and improving the survival time of liver cancer patients are promising but require further validation in future studies.

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Association of heartbeat complexity with survival in advanced non-small cell lung cancer patients

Cited by 2 publications

References 61 publications

Effect of “needle sensation” and the real-time changes in autonomic nervous system activity during acupuncture analgesia

Effect of “needle sensation” and the real-time changes in autonomic nervous system activity during acupuncture analgesia

The Prognostic Correlation of Heart rate variability and body weight status in liver cancer patients

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