Association of Heart-Type Fatty Acid-Binding Protein with Cardiovascular Risk Factors and All-Cause Mortality in the General Population: The Takahata Study

Abstract

BackgroundDespite many recent advances in medicine, preventing the development of cardiovascular diseases remains a challenge. Heart-type fatty acid-binding protein (H-FABP) is a marker of ongoing myocardial damage and has been reported to be a useful indicator for future cardiovascular events. However, it remains to be determined whether H-FABP can predict all-cause and cardiovascular deaths in the general population.Methods and ResultsThis longitudinal cohort study included 3,503 subjects who participated in a community-based health checkup with a 7-year follow-up. Serum H-FABP was measured in registered subjects. The results demonstrated that higher H-FABP levels were associated with increasing numbers of cardiovascular risk factors, including hypertension, diabetes mellitus, obesity, and metabolic syndrome. There were 158 deaths during the follow-up period, including 50 cardiovascular deaths. Deceased subjects had higher H-FABP levels compared to surviving subjects. Multivariate Cox proportional hazard regression analysis revealed that H-FABP is an independent predictor of all-cause and cardiovascular deaths after adjustments for confounding factors. Subjects were divided into four quartiles according to H-FABP level, and Kaplan-Meier analysis demonstrated that the highest H-FABP quartile was associated with the greatest risks for all-cause and cardiovascular deaths. Net reclassification index and integrated discrimination index were significantly increased by addition of H-FABP to cardiovascular risk factors.ConclusionsH-FABP level was increased in association with greater numbers of cardiovascular risk factors and was an independent risk factor for all-cause and cardiovascular deaths. H-FABP could be a useful indicator for the early identification of high-risk subjects in the general population.

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“…H-FABP is more specific for heart muscle than are other types of fatty acid binding protein 30,31 . H-FABP is undetectable in normal conditions but is released rapidly from cardiomyocytes into circulating blood after myocardial damage.…”

Chronic drug‐induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell‐derived cardiomyocytes

“…Secondly, FABP3 might be a sensitive marker for various cardiovascular risks, beyond acute myocardial injury. Indeed, a large population study showed that higher serum levels of FABP3 are associated with a great number of cardiovascular risks, suggesting that it could predict overall cardiovascular mortality within a general population (Otaki et al, 2014). However, cTnI seems to be a more sensitive biomarker for myocardial damage based on our functional, biomarker and transcriptional data, and therefore, a combined assessment of cTnI and FABP3 could be a valuable surrogate to evaluate chronic cardiotoxicity in hiPS-CMs.…”

Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

“…H-FABP levels were measured using a two-step sandwich enzyme-linked immunosorbent assay (ELISA) kit (MARKIT-M H-FABP, Dainippon Pharmaceutical Co. Ltd., Tokyo, Japan), as previously described [15, 16]. …”