Association of hearing impairment with chronic kidney disease: a cross-sectional study of the Korean general population

Seo, Young Joon; Ko, Sang Baek; Ha, Tae Hyung; Gong, Tae Hoon; Bong, Jeong Pyo; Park, Dong Joon; Park, Sang Yoo

doi:10.1186/s12882-015-0151-0

Cited by 37 publications

(42 citation statements)

References 16 publications

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“…The association between kidney function decline and hearing loss found in our study was consistent with some previously published studies [23,24]. Seo et al [24] found that an eGFR < 60 mL/min/1.73 m 2 had a significant independent influence on the hearing status of adults, and they reported that the OR of hearing impairment in participants with eGFR < 60 mL/min/1.73 m 2 was 1.25…”

Section: Discussionsupporting

confidence: 92%

“…It is a little bit difficult to compare the prevalence of hearing loss in this study with previous studies due to the fact that the included participants in different studies were in different age groups, and the hearing loss was defined and measured using different instruments in different studies. The pure-tone audiometry and self-reporting are two common ways to assess hearing status in hearing related studies [23,24,[29][30][31][32][33][34]. Pure tone audiometry is to find the hearing threshold at a specific frequency [22].…”

Section: Discussionmentioning

confidence: 99%

“…However, most of those existent studies had small sample sizes and the enrolled patients were with kidney failure, and few studies focused on the association between hearing loss and mild-to-moderate chronic kidney function decline in large population [23,24]. Vilayur et al [23] presented the first community-based study and demonstrated an association between moderate CKD and hearing loss in Australian population.…”

mentioning

confidence: 99%

“…Vilayur et al [23] presented the first community-based study and demonstrated an association between moderate CKD and hearing loss in Australian population. Seo et al [24] found individuals with CKD were more likely to have hearing impairment, based on the Korean National Health and Nutritional Examination Survey. But the sample size of their study was also relatively small, and only the hearing status of two different eGFR groups: ≥ 60 and < 60 mL/min/1.73 m 2 were compared.…”

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confidence: 99%

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The association between kidney function decline and hearing loss: a cross-sectional study

Liu

Meng

Wang

et al. 2019

Preprint

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Background The relationship between kidney function and hearing loss has long been recognized, but evidence mostly come from small observational studies. The aim of this study is to explore the association between kidney function decline and hearing loss in a large population-based study.Methods Data collected in the Chinese Health and Retirement Longitudinal Study (CHARLS) in 2015 was used for analysis. A cross-sectional study was conducted among 12508 participants aged 45 years and older. Hearing loss, the outcome of this study, was defined based on interviewees' responses to three survey questions about hearing in the CHARLS study. Estimated glomerular filtration rate (eGFR) was employed to assess kidney function, and participants were classified into three categories based on eGFR: ≥ 90, 60-89 and < 60 mL/min/1.73m2. Multivariable Logistic regression was employed to adjust for potential confounders, including demographics, health related behaviors, and cardiovascular risk factors.Results The overall prevalence of self-reported hearing loss in the study population was 23.55%. Compared with participants having eGFR ≥ 90 mL/min/1.73m2, there was an increased risk of hearing loss among those participants with eGFR of 60-89 mL/min/1.73m2 (odds ratio: 1.11, 95% confidence interval: 1.00-1.22) and eGFR < 60 mL/min/1.73m2 (odds ratio: 1.26, 95% confidence interval: 1.05-1.51) after adjusting for potential confounders.Conclusions Kidney function decline was independently associated with hearing loss.Testing for hearing should be included in the integrated management among patients with chronic kidney disease. BackgroundThe World Health Organization (WHO) reported that around 432 million adults suffer from disabling hearing loss in 2018, and it is estimated that over 900 million people will have disabling hearing loss by 2050 [1]. Hearing loss in adults not only bring communication difficulties in daily life, but also have negative impacts on cognitive and psychosocial function, lead to social isolation, cause financial strain and finally lower health-related quality of life indirectly [2][3][4]. As most hearing loss are acquired and hard to get recovered, but could be prevented, exploring the risk factors of hearing loss has great significance.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The association between kidney function decline and hearing loss: a cross-sectional study

Liu

Meng

Wang

et al. 2019

Preprint

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“…In our study we have performed a correlation study between eGFR and PTA parameters and our result were comparable to Seo et al, who found that the correlation between eGFR and mean thresholds at low, mid, and high frequency ranges had meaningful negative correlations with eGFR values. 22 We performed a stage wise distribution of CKD patients according to their severity, and we found that for low frequency range in stage 2 and 3 patients, maximum hearing loss was of mild to moderate degree in nature, whereas in stage 4 and 5, maximum hearing loss was also mild to moderate in nature. Although severe to profound hearing loss was also more in stage 4 and 5 patients as compared to stage 2 and 3.…”

Section: Discussionmentioning

confidence: 93%

Hearing assessment in chronic kidney disease patients: a cross-sectional study

Jain

Upadhyay

Aftab

et al. 2020

Int J Otorhinolaryngol Head Neck Surg

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Background: It is well known that chronic kidney disease (CKD) causes different systemic and otorhinolaryngologic manifestations due to the accumulation of waste products, osmotic alteration, and antigenic similarity between basement membrane of the glomerulus and stria vascularis of the inner ear. Methods: The study subjects were divided into two groups, 50 CKD patients and 50 healthy volunteers in age group 15-60 years. All CKD patients and controls were subjected to hearing assessment using standard pure tone audiometry. Results: For low frequency hearing loss increased from stage 2 and 3 to stage 4 and 5, and for high frequency hearing loss among stage 2 and 3 CKD patients was mild to moderate (65.22%) in nature and hearing loss increased in intensity (i.e. severe to profound) in stage 4 and 5 of CKD patients. Dialysis patients were having more severe hearing loss in comparison to non dialysis patients. Hearing loss was negatively correlated with the eGFR. And positively correlated with the duration of the disease (CKD).Conclusions: Our study highlights the pattern of hearing loss in people suffering from chronic kidney disease who were either on dialysis or not on dialysis. Early identification can prevent further deterioration of hearing in patients suffering from chronic kidney disease.

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Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing

et al. 2018

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The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigated the role of the exocyst in cochlear development and hearing by targeting EXOC5, a central exocyst component. Deleting Exoc5 in the otic epithelium with widely used Cre lines resulted in early lethality. Thus, we generated two different inner ear-specific Exoc5 knockout models by crossing Gfi1 mice with Exoc5 mice for hair cell-specific deletion (Gfi1;Exoc5) and by in utero delivery of rAAV-iCre into the otocyst of embryonic day 12.5 for deletion throughout the otic epithelium (rAAV2/1-iCre;Exoc5). Gfi1;Exoc5 mice showed relatively normal hair cell morphology until postnatal day 20, after which hair cells underwent apoptosis accompanied by disorganization of stereociliary bundles, resulting in progressive hearing loss. rAAV2/1-iCre;Exoc5 mice exhibited abnormal neurite morphology, followed by apoptotic degeneration of spiral ganglion neurons (SGNs) and hair cells, which led to profound and early-onset hearing loss. These results demonstrate that Exoc5 is essential for the normal development and survival of cochlear hair cells and SGNs, as well as the functional maintenance of hearing.

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Association of hearing impairment with chronic kidney disease: a cross-sectional study of the Korean general population

Cited by 37 publications

References 16 publications

The association between kidney function decline and hearing loss: a cross-sectional study

The association between kidney function decline and hearing loss: a cross-sectional study

Hearing assessment in chronic kidney disease patients: a cross-sectional study

Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing

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