Association of handgrip strength with all-cause mortality: a nationally longitudinal cohort study in China

Wang, Yuhan; Liu, Yang; Hu, Jiajin; Guan, Hongcai; Wang, Yewei; Liu, Ming; He, Liang; Sun, Naihui; Yang, Wanshui; Ma, Yanan

doi:10.1016/j.jsams.2022.08.005

Cited by 11 publications

(3 citation statements)

References 26 publications

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“…Hand grip strength (HGS) was measured using the right or left hand with a dynamometer (Yuejian™ WL-1000, Nantong, China) in kilograms at a right angle (90˚) for a few seconds as hard as possible. Each hand was tested twice and the maximum value of the four attempts was extracted for the next analysis [ 22 ]. The cut-off points for low grip strength were defined as < 28.0 kg for men and < 18.0 kg for women.…”

Section: Methodsmentioning

confidence: 99%

Associations of sarcopenia with peak expiratory flow among community-dwelling elderly population: based on the China Health and Retirement Longitudinal Study (CHARLS)

Jin

Chang

et al. 2023

Eur Geriatr Med

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Purpose To cross-sectionally and longitudinally investigate the correlations of sarcopenia and its components with peak expiratory flow (PEF) among Chinese community-dwelling elderly people. Methods The data were extracted from the China Health and Retirement Longitudinal Study (CHARLS). A total of 4053 participants aged ≥ 60 years were enrolled from CHARLS 2011, and 2810 were followed up until 2015. Participants were classified into no-sarcopenia, non-severe sarcopenia, and severe sarcopenia groups based on skeletal muscle mass index (SMI), hand grip strength (HGS), and physical performance [gait speed, five-repetition chair stand test (5CST) and short physical performance battery (SPPB)]. Multivariate linear and logistic regression analyses were used to evaluate the associations of sarcopenia and its components with PEF cross-sectionally and longitudinally. Results In the cross-sectional analysis, the prevalence of non-severe sarcopenia was 14.6% and severe sarcopenia was 4.9%. The results of linear regression analysis revealed that sarcopenia and its components were all correlated with PEF and PEF%pred. In the longitudinal analysis, compared with non-sarcopenia, subjects with severe sarcopenia were associated with a higher risk of PEF (OR = 2.05, 95%CI = 1.30–3.26) and PEF%pred (OR = 1.83, 95%CI = 1.17–2.86) decline. The changes in physical performance were correlated with changes in PEF and PEF%pred. No associations were observed between changes in SMI and PEF as well as PEF%pred. Conclusions We demonstrated the associations of baseline sarcopenia status with PEF and longitudinal PEF decline. Also, the changes in physical performance were associated with changes in PEF during a 4-year follow-up. It indicates that improving sarcopenia, especially physical performance may increase PEF.

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Section: Methodsmentioning

confidence: 99%

Associations of sarcopenia with peak expiratory flow among community-dwelling elderly population: based on the China Health and Retirement Longitudinal Study (CHARLS)

Jin

Chang

et al. 2023

Eur Geriatr Med

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“…The survival status of participants was ascertained through field investigations conducted by interviewers during four separate follow-up periods. Interviewers visited the residences of participants and, in the event of the participant’s death, collected relevant information by interviewing household members who lived with the deceased ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

The relationship between sarcopenia and mortality in Chinese community-dwelling adults: a 7-year cohort study with propensity score matching and Mendelian randomization

Xiong,

Liao,

Guo

et al. 2023

Front. Endocrinol.

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BackgroundSarcopenia has been linked to adverse health outcomes, including an increased risk of mortality. This study aimed to assess the 7-year mortality risk of sarcopenia in a community-based population in China and explore the causal relationship between components of sarcopenia and any death.MethodsData were sourced from the China Health and Retirement Longitudinal Study (CHARLS) conducted between 2011 and 2018. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Logistic regression, Kaplan–Meier (KM) survival analysis, and propensity score matching with inverse probability of treatment weighting were used. Mendelian randomization (MR) analyses, conducted using European population data, were utilized to assess causality between sarcopenia and any death.ResultsThe study included 9,006 participants: 3,892 had no sarcopenia, 3,570 had possible sarcopenia, 1,125 had sarcopenia, and 419 had severe sarcopenia. Over 7 years of follow-up, there were 871 deaths, including 196 with sarcopenia and 133 with severe sarcopenia. The KM curves showed that sarcopenia had a higher risk of mortality. Compared to those of no sarcopenia, the odds ratios (ORs) of sarcopenia for 7-year mortality were 1.41 (95% CI, 1.06–1.87) after adjusting for confounding variables (p < 0.05). The ORs of severe sarcopenia were 2.11 (95% CI, 1.51–2.95). Propensity score matching analysis and inverse probability of treatment weighting analysis confirmed these findings. The adjusted ORs of sarcopenia and 7-year mortality were 2.94 (95% CI, 1.6–5.39) in the 45–60 age group, 1.72 (95% CI, 1.11–2.68) in the 60–80 age group, and 5.03 (95% CI, 0.48–52.65) in the ≥80 age group. The ORs of severe sarcopenia and 7-year mortality were 6.92 (95% CI, 1.95–24.5) in the 45–60 age group, 2.59 (95% CI, 1.61–4.17) in the 60–80 age group, and 12.52 (95% CI, 1.18–133.18) in the ≥80 age group. The MR analyses, leveraging the inverse variance weighted (IVW) method, unveiled substantial causal links between low hand grip strength in individuals aged 60 and older, the usual walking pace, and mortality risk.ConclusionThis study underscores the significant impact of sarcopenia and its components on mortality risk within the Chinese population. Particularly, low hand grip strength and usual walking pace emerged as noteworthy contributors to mortality risk.

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“…A secondary analysis of the National Health and Nutrition Examination Survey from 2011 to 2014 showed a substantial inverse relationship between handgrip strength and depression in community-dwelling, non-institutionalized people in the United States aged ≥ 60 years [ 24 ]. Furthermore, people with low handgrip strength had a higher mortality risk than normal [ 25 , 26 ]. Also, the findings of a recent study indicate that inadequate handgrip strength may serve as a partial mediator of the effect of anemia on health-related quality of life [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Biological ageing and the risk of decreased handgrip strength among community-dwelling older adult Indians: a cross-sectional study

Vennu

2023

BMC Geriatr

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Background Evidence from the literature demonstrates that the risk of decreased handgrip strength is associated with various health issues, particularly in older persons. To make judgments regarding their general health condition that are well-informed for longevity, it is crucial to assess the risk level of decreased handgrip strength among community-dwelling older adult Indians. However, no study has examined the relationship between biological aging and the risk of decreased handgrip strength in Indian men and women aged 60 and older. The goal of the current study was to fill this gap in the literature. Methods In this cross-sectional study, we included 31,464 (15,098 men and 16,366 women) community-dwelling older adult Indians aged 60 years and older using data from the Longitudinal Aging Study in India (LASI). The LASI is the world’s most extensive and India’s first multidisciplinary, internationally harmonized, longitudinal aging study. It has enrolled 72,250 individuals aged 45 and above across all 28 states and 8 union territories of India. Secondary analysis of biological ageing was performed by stratifying for age groups (60–64, 65–69, 70–74, 75–79, 80–84, and 85 + years) for both genders. The dominant right and nondominant left handgrip strength was assessed using the portable Smedley’s Hand Dynamometer. All individuals had a dominant right hand. The adjusted logistic regression analysis assessed the association between biological ageing and the risk of decreased handgrip strength for both genders. Results Compared to those between the ages of 60–64, those at age 65 and those aged 85 and above had 1-fold and 12-fold odds of decreasing handgrip strength, respectively. Men 85 years or older had a 12-fold higher chance than women in the same age group of having decreased handgrip strength. Conclusions The results indicate that community-dwelling older adult Indians aged 65 years and older are significantly associated with a higher risk of decreased handgrip strength, especially among older men. The results of this study can help assess and implement handgrip strength measurement in medicine for older Indians as part of regular admission assessment, particularly for older men.

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Association of handgrip strength with all-cause mortality: a nationally longitudinal cohort study in China

Cited by 11 publications

References 26 publications

Associations of sarcopenia with peak expiratory flow among community-dwelling elderly population: based on the China Health and Retirement Longitudinal Study (CHARLS)

Associations of sarcopenia with peak expiratory flow among community-dwelling elderly population: based on the China Health and Retirement Longitudinal Study (CHARLS)

The relationship between sarcopenia and mortality in Chinese community-dwelling adults: a 7-year cohort study with propensity score matching and Mendelian randomization

Biological ageing and the risk of decreased handgrip strength among community-dwelling older adult Indians: a cross-sectional study

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