Association of habitually low intake of dietary selenium with new-onset stroke: A retrospective cohort study (2004–2015 China Health and Nutrition Survey)

Abstract

BackgroundAs an essential trace element in the body, selenium is associated with the development of many diseases. The purpose of this study was to explore the association between dietary selenium intake and new-onset stroke risk in Chinese adults.MethodsAdults aged ≥18 years in the China Health and Nutrition Survey (CHNS) from 2004 to 2015 were enrolled. Participants were divided into five groups according to the quintile of dietary selenium intake: Q1 (≤ 29.80 μg/day), Q2 (29.80–38.53 μg/day), Q3 (38.53–47.23 μg/day), Q4 (47.23–60.38 μg/day), Q 5(>60.38 μg/day). Cox proportional-hazards model was used to explore the effect of dietary selenium on new-onset stroke. Restricted cubic spline (RCS) was used to visualize the dose-response relationship between dietary selenium and the risk of morbidity.ResultsA total of 11,532 subjects were included, and 271 (2.35%) of them developed stroke during a mean follow-up of 6.78 person-years. Compared with the lowest selenium intake group, the HR and 95%CI of stroke in the participants with selenium intake of Q2, Q3, Q4 and Q5 were: 0.85 (0.59, 1.21), 0.62 (0.42, 0.92), 0.43 (0.28, 0.68), 0.49 (0.30, 0.82), respectively. There was an L-shaped relationship between dietary selenium and stroke (nonlinear P-value = 0.0420). The HR and 95%CI of developing stroke was 0.75 (0.65, 0.87) in participants with selenium intake ≤ 60 μg/day.ConclusionsThe L-shaped negative association between dietary selenium and stroke in Chinese adults which indicated that dietary selenium should be improved to a certain level to prevent stroke.

Effect of dietary selenium intake on CVD: a retrospective cohort study based on China Health and Nutrition Survey (CHNS) data

“…Interestingly, adding S e to the antioxidant mix is significant in reducing all-cause death from CVD ( 38 ) . By contrast, some researchers found that dietary S e intake is inversely associated with cardiovascular mortality, CHD risk, chronic heart failure, angina, heart attack and stroke ( 39 – 41 ) . S e constitutes a dietary factor with protective action against cardiovascular pathologies in several animals and epidemiological studies ( 42 ) .…”

“…S e deficiency is common amongst Chinese residents. Dietary S e intake should be increased to 50–60 μg/d in the general population of China to maximise stroke prevention and maintain health, and the association between S e and stroke was stronger in the group with high S e intake than in the group with low intake ( 41 ) . This result was inconsistent with the findings of our study, possibly because of the samples and research period between the two studies.…”

Nonlinear associations of dietary selenium intake with all-cause and cardiovascular mortality after stroke in US adults: findings from NHANES 1999-2018

“…The association between dietary selenium and stroke prevalence was L-shaped, with dietary selenium associated with reduced stroke odds until 350 µg/d and a plateau thereafter. Zhang et al [14] included 11,532 participants from the China Health and Nutrition Survey 2004-2015 in a retrospective cohort study and suggested that the protective effect of dietary selenium intake on stroke risk was only present at ≤ 60 µg/d, with no signi cant associations thereafter. These studies consistently indicated an inverse association of dietary selenium intake with stroke occurrence, whereas excessive selenium intake had no additional protective effect.…”

“…A recent study using the National Health and Nutrition Examination Survey (NHANES) database indicated that dietary selenium intake was inversely associated with the prevalence of stroke in the U.S. population [12]. Similar ndings from other countries have demonstrated a negative correlation between dietary selenium intake and the occurrence of stroke [13,14]. However, there is still a lack of exploration regarding the effect of dietary selenium intake on mortality in stroke survivors.…”

Association between selenium intake and migraine: a nationwide cross-sectional study

“…It is well known that selenium is an important antioxidant and an essential trace element for human health, and dietary intake is the main form of body supplementation ( Wang et al, 2017 ; Rayman, 2020 ). Previous researches have shown that selenium intake can help improve psychoneurological disorders such as stroke, Parkinson’s, and depression through its antioxidant properties ( Li et al, 2018 ; Sun et al, 2022 ; Zhang et al, 2022 ). Some migraineurs have lower serum catalase activity, non-oxidative thiol concentrations, and total antioxidant capacity.…”