Association of Habitual Snoring with Glucose and Insulin Metabolism in Nonobese Korean Adult Men

Abstract

Habitual snoring is associated with cardiovascular morbidity and mortality, and metabolic abnormalities such as impaired glucose homeostasis. Many studies were performed in obese Western populations. The purpose of this study was to examine the association of habitual snoring with glucose and insulin metabolism in nonobese Korean men who were free of diabetes and hypertension. A total of 2,719 men ages 40-69 years from the Korean Health and Genome Study participated in this study. Information of snoring frequency was obtained by a questionnaire and glucose and insulin levels during oral glucose tolerance test were measured. Repeated measures analysis of variance detected significant differences in the changing patterns of glucose and insulin levels at 1 hour and 2 hours between habitual snorers and nonhabitual snorers, whereas there were no significant differences in fasting blood glucose and insulin levels. Multivariate logistic regression analyses revealed that habitual snoring was independently associated with elevated 1-hour and 2-hour glucose levels and a 2-hour insulin level, respectively. The present data suggest that habitual snoring may affect glucose-insulin metabolism, independent of diabetes and hypertension, even in nonobese Korean middle-age men. Further prospective studies are needed to examine the causal relationship between habitual snoring and insulin resistance or glucose intolerance.

Simple snoring: Not quite so simple after all?

“…In a sample of middle-aged non-obese males habitual snorers compared to non-snorers had a 2-fold increased risk of elevated haemoglobin -an independent indicator of long-term glycaemic control, and thus, a potential risk factor for metabolic syndrome and cardiovascular disease (69). Shin and colleagues demonstrated that, whilst habitual snorers' and non-snorers' levels of fasting blood glucose and insulin were comparable, habitual snoring was associated with elevated glucose and insulin levels 2 hours following ingestion of glucose even after controlling for diabetes and hypertension in non-obese individuals (73). This study suggests that snoring may contribute to insulin resistance and impaired glucose homeostasis.…”

Prevalence of Sleep Disordered Breathing Symptoms and Their Relation with Concomitant Diseases in Afyon, Turkey: A Population Based Study

“…Shin et al 37 re por ted that ha bi tu al sno rers had sig ni fi cantly hig her glu co se and in su lin le vels at 2 nd h of oral glu co se to le ran ce test as com pa red to nonha bi tu al sno rers, whi le fas ting glu co se or in su lin le vels did not dif fer sig ni fi cantly bet we en the groups. In a po pu la ti on-ba sed samp le of hyper ten si ve men, the pre va len ce of obs truc ti ve sle ep ap ne a was sig ni fi cantly hig her in di a be tic pa ti ents than in nor mogl yce mic sub jects, in de pen dent of cen tral obe sity.…”

“…To analy ze the in de pen dent inf lu en ce of snoring on the so ma tic di se a ses, mul ti va ri a te mo dels we re used, with ad just ment for age, BMI, al co hol ad dic ti on and smo king sta tus. Age was ca te go ri zed in to in ter vals (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44), 45-64, 65-74, >75) in the mul tip le analy sis, whi le BMI was ca te go ri zed in to fo ur in ter vals (<25: nor mal, 25.0-29.9: overwe ight, 30.0-39.9: obe se, >40: mor bid obe se).…”

Insulin resistance and affecting factors in patients with obstructive sleep apnea syndrome

“…In a study conducted on Korean males who were not hypertensive, diabetic and obese, it was reported that although fasting blood glucose and insulin levels were not different, glucose and insulin levels were found to be significantly higher in patients with habitual snoring at the 1st and 2nd hours than those without habitual snoring in a 75 g oral glucose tolerance test. 6 Diabetes mellitus was found in 5.4% of patients with habitual snoring and 2.41% of patients without habitual snoring as a result of a 10 year follow-up. 7 In our study, 42 of 85 patients with OSAS (49.4%) were found to have insulin resistance.…”