Association of GSTM1 and GSTT1 with ageing in auto repair shop workers

Eshkoor, Sima Ataollahi; Marashi, None Seyed Jalal; Ismail, Patimah; Rahman, Sabariah Abdul; Mirinargesi, M.; Adon, Mohd Yusoff; Devan, R. V.

doi:10.4238/2012.may.21.5

Cited by 8 publications

(6 citation statements)

References 29 publications

(39 reference statements)

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“…In the same study population, GSTT1 and GSTM1 polymorphisms showed significant differences in DNA damage markers in buccal cells between workers and controls 31. Previous studies have demonstrated that GSTM1 enzymes protect cells against oxidative stress, and lack of GSTM1 enzymes increases oxidative DNA damage in smokers 32.…”

Section: Tl and Exposure To Environmental And Occupational Chemicalsmentioning

confidence: 71%

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Republished: Environmental and occupational exposure to chemicals and telomere length in human studies

Zhang

Lin

Funk

et al. 2013

Postgraduate Medical Journal

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Telomeres are complexes of tandem repeats of DNA (5'-TTAGGG-3') and protein that cap eukaryotic chromosomes and play a critical role in chromosome stability. Telomeres shorten with aging and this process can be accelerated by increased oxidative stress and episodes of inflammation. Evidence is rapidly growing that telomere length (TL) may be affected by environmental chemicals that have frequently been associated with chronic diseases. In this article, we review the published data on TL in relation to environmental and occupational exposure to several chemicals based on our own and others' studies. The environmental and occupational exposures associated with shorter TL include traffic-related air pollution (ie, particulate matter (PM), black carbon (BC), and benzene and toluene), polycyclic aromatic hydrocarbons (PAHs), N-nitrosamines, pesticides, lead, exposure in car mechanical workshops, and hazardous waste exposure. Arsenic, persistent organic pollutants (POPs) and short-term exposure to PM are associated with longer TL. We discuss the possible reasons for the differences in results, including time- and dose-related issues, study design, and possible mechanisms involved in telomere regulation. We also discuss the future directions and challenges for TL-related environmental and occupational health research, such as investigation of TL in subpopulations of blood leukocytes, and the study of genetic and epigenetic factors that may regulate telomere integrity using longitudinal designs.

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Section: Tl and Exposure To Environmental And Occupational Chemicalsmentioning

confidence: 71%

“…The glutathione S-transferase (GST) genes, including GSTT1 , GSTM1 and GSTP1 , play an important role in detoxifying xenobiotics 31. In the same study population, GSTT1 and GSTM1 polymorphisms showed significant differences in DNA damage markers in buccal cells between workers and controls 31.…”

Section: Tl and Exposure To Environmental And Occupational Chemicalsmentioning

confidence: 93%

Republished: Environmental and occupational exposure to chemicals and telomere length in human studies

Zhang

Lin

Funk

et al. 2013

Postgraduate Medical Journal

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“…Several studies support our results. Eshkoor et al (2012) found a higher prevalence of the GSTT1 null genotype (62.5%) in Malaysia. A lower prevalence was described by Nelson et al (1995), and only 9.7% of Mexican-Americans analyzed in the city of Boston had the null polymorphism of the GSTT1 gene.…”

Section: Discussionmentioning

confidence: 82%

Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás

Rodrigues¹,

Costa²,

Martins³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested that individuals with homozygous deletion of glutathione S-transferase mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) are at higher risk of developing several types of neoplasias. The p53 protein is highly expressed in tumors and transformed cells, and the p53 is a classical tumor suppressor gene involved in regulating cell growth and development. In this study, we investigated the prevalence of polymorphisms in the p53, GSTM1, and GSTT1 genes in a population from Goiânia. We evaluated the polymorphisms of these genes in peripheral blood samples. The null or present polymorphism of GSTM1 and GSTT1 17359Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 17358-17365 (2015) genes and Arg/Pro of the p53 gene were analyzed. Our results revealed a higher frequency of the GSTM1-null polymorphism (72.4%) than the GSTM1-present genotype (27.6%). For GSTT1, we observed higher frequency for the null genotype (65.5%) compared to the present genotype (34.5%). Analysis of p53 gene polymorphisms showed a higher frequency for the genotype Arg/Pro (66%) and a lower frequency for the Arg/Arg (23%) and Pro/Pro (11%) genotypes. It is essential to understand polymorphism frequencies in different populations and to evaluate the role of genetic polymorphisms and their effects on health.

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“…GSTM1 and GSTT1 enzymes decrease oxidative damage and prevent induced genotoxic attacks on DNA [ 52 ]. Many studies have explored the role of GSTM1 and GSTT1 polymorphisms in the genotoxic damage and telomere length [ 53 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

The Leucocyte Telomere Length, GSTM1 and GSTT1 Null Genotypes and the Risk of Chronic Obstructive Pulmonary Disease

Tacheva

Zienolddiny

Dimov

et al. 2022

CIMB

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Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and oxidative stress both in the airways and blood and other organs. Elevated oxidative stress and inflammation have been reported to affect leucocyte telomere length (LTL). Glutathione S-transferase (GST) enzymes are a large family of xenobiotic-metabolizing enzymes that utilize different ROS products. We aimed to explore the link between GSTM1 and GSTT1 gene polymorphisms, LTL and COPD risk. For GSTM1, we genotyped 152 COPD patients and 131 non-affected controls; for GSTT1, we genotyped 149 COPD patients and 130 controls. We were able to assess TL for 91 patients and 88 controls. There was a significant difference in the GSTM1 null genotype frequency between the patients and controls (0.59 vs. 0.38, p ≤ 0.000), but such was not found for GSTT1 (p = 0.192). When combining both polymorphisms, we obtained a significantly greater presence of at least one null genotype among patients (0.12 vs. 0.05, p = 0.027). An association between GSTT1 and LTL was not found. COPD patients carrying the GSTM1 null genotype had shorter telomeres compared to those carrying the non-null genotype (15,720 bp vs. 22,442 bp, p = 0.008); as for the controls, it was the opposite (31,354 bp vs. 17,800 bp, p = 0.020). The significance in both groups remained when combining GSTM1 and GSTT1 (COPD (at least one null) 16,409 bp vs. COPD (non-null) 22,092 bp, p = 0.029; control (at least one null) 29,666 bp vs. control (non-null) 16,370 bp, p = 0.027). The total glutathione level in GSTM1 non-null controls was higher compared to the null genotype (15.39 ng/mL vs. 5.53 ng/mL, p = 0.002). In COPD patients, we found no association (p = 0.301). In conclusion, according to our results, GSTM1, but not GSTT1, null genotypes might play a role in leucocyte telomere shortening, and thus be involved in the pathogenesis of COPD.

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Association of GSTM1 and GSTT1 with ageing in auto repair shop workers

Cited by 8 publications

References 29 publications

Republished: Environmental and occupational exposure to chemicals and telomere length in human studies

Republished: Environmental and occupational exposure to chemicals and telomere length in human studies

Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás

The Leucocyte Telomere Length, GSTM1 and GSTT1 Null Genotypes and the Risk of Chronic Obstructive Pulmonary Disease

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